Rossah, Nabila Hardina and M. Kes, Dr. drg. Yuanita Lely Rachmawati (2022) Uji In Silico Perbandingan Efektivitas Daun Binahong dan Triamcinolone Acetonide Terhadap IL-6. Sarjana thesis, Universitas Brawijaya.
Abstract
Recurrent Aphthous Stomatitis (RAS) adalah salah satu penyakit inflamasi berkarakteristik ulserasi rekuren yang paling sering dijumpai di mukosa rongga mulut pada berbagai kalangan usia. RAS memiliki banyak faktor predisposisi seperti trauma mekanik, malnutrisi, menstruasi, alergi, stress dan sebagainya. Ditandai dengan gejala prodromal seperti rasa terbakar, nyeri dan gatal. Respon imun pada penderita RAS salah satunya adalah peningkatan sitokin IL-6. Tujuan : Untuk mengetahui perbandingan efektivitas daun binahong (Anredera Codrfifolia) dan triamcinolone acetonide terhadap mediator inflamasi IL-6 melalui uji in silico. Metode : Menggunakan metode in silico yaitu dengan Molecular docking dengan menginteraksikan beberapa ligan, yaitu Vitexin (CID 5280441), dan senyawa Saponin (CID 198016) dengan protein Interleukin-6 (ID 4J4L). Ligan pembanding yang digunakan, yakni Triamcinolone Acetonide (CID 6436). Hasil dan Pembahasan : Melalui molecular docking didapatkan hasil bahwa interaksi kompleks binahong mampu menghambat mediator Interleukin-6 ditunjukkan oleh energi ikatan yang paling rendah dibandingkan dengan ligan pembandingnya. Sedangkan melalui uji drug-likeness, kompleks daun binahong memiliki aktivitas antiinflamasi dan farmakologi yang berpotensi sebagai obat Recurrent Aphthous Stomatitis (RAS). Kesimpulan : Terdapat perbedaan dari perbandingan efektivitas daun binahong (Anredera cordifolia) dan triamcinolone acetonide terhadap mediator inflamasi IL-6 pada Reccurent Aphthous Stomatitis.
English Abstract
Recurrent aphthous stomatitis (RAS) is an inflammatory disease characterized by recurrent ulceration that is most often found in the oral mucosa at various ages. RAS has many predisposing factors such as mechanical trauma, malnutrition, menstruation, allergies, stress and so on. It is characterized by prodromal symptoms such as burning, pain, and itching. One of the immune responses in patients with RAS is an increase in the cytokine IL-6. The purpose : To compare the effectiveness of binahong leaves (Anredera Codrfifolia) and triamcinolone acetonide against IL-6 inflammatory mediators through the in silico test. Method : Using the in silico method, namely Molecular docking by interacting several ligands, namely Vitexin (CID 5280441), and Saponin compounds (CID 198016) with Interleukin-6 protein (ID 4J4L). The comparison ligand used was Triamcinolone Acetonide (CID 6436). Research Results and Discussion : Through molecular docking, it was found that the interaction of the binahong complex was able to inhibit the mediator Interleukin-6, indicated by the lowest binding energy compared to its comparison ligand. Meanwhile, through the druglikeness test, the binahong leaf complex has anti-inflammatory and pharmacological activity that has the potential as a Recurrent Aphthous Stomatitis (RAS) drug. Conclusion : There is a difference in the comparison of the effectiveness of binahong leaves (Anredera cordifolia) and triamcinolone acetonide against IL-6 inflammatory mediators in Recurrent Aphthous Stomatitis.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0522140028 |
| Uncontrolled Keywords: | Recurrent Aphthous Stomatitis (RAS), Daun Binahong, IL-6, In Silico, Recurrent Aphthous Stomatitis (RAS), Binahong leaves, IL-6, In Silico |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Sugeng Moelyono |
| Date Deposited: | 15 May 2023 02:11 |
| Last Modified: | 15 May 2023 02:16 |
| URI: | http://repository.ub.ac.id/id/eprint/199513 |
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Text (DALAM MASA EMBARGO)
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