Rachmatillah, Amira and drg. Diena Fuadiyah,, M.Si (2022) Potensi Nanoliposom Ekstrak Kunyit (Curcuma longa L.) pada Wound Healing: Studi Literatur. Sarjana thesis, Universitas Brawijaya.
Abstract
Latar belakang studi ini yaitu kurkumin pada Curcuma Longa L. efektif dalam penyembuhan luka, tetapi memiliki bioavailabilitas yang rendah dan hidrofobik sehingga diperlukan sistem penghantaran obat. Sistem penghantaran obat dapat dilakukan dengan berbagai cara, salah satunya dengan cara kurkumin dienkapsulasikan dalam nanoliposom Studi ini bertujuan mengetahui pengaruh nanoliposom ekstrak Curcuma longa pada wound healing dengan diabetes melitus dari studi literatur. Metode yang digunakan pada studi ini yaitu Systematic literature review dengan menggunakan metode PRISMA (Preferred Reporting Items for Systematic Reviews and Meta- analyses). Hasil studi ini yaitu berdasarkan hasil dari studi literature review yang sudah dilakukan oleh peneliti, didapatkan sejumlah 10 artikel, 3 artikel membahas mengenai kandungan nanoformulasi kurkumin terkait dengan wound healing. 4 artikel membahas jenis sediaan kurkumin pada wound healing. Selain itu, 3 artikel membahas pengaruh kurkumin terhadap biomarker wound healing. Kesimpulan studi ini yaitu berdasarkan studi literatur yang sudah dilakukan oleh peneliti dari sejumlah 10 artikel dapat disimpulkan bahwa beberapa kandungan ekstrak Curcuma longa memiliki pengaruh pada wound healing dengan tiga aktivitas biologis utama yaitu anti- inflamasi, anti-oksidasi, dan anti-mikroba dengan adanya re- epitelisasi dengan penurunan ekspresi TNF-α, IL-1β dan MMP-9, peningkatan kadar IL-10, SOD, katalase dan glutathione peroksidase, dan mobilisasi fibroblas.
English Abstract
The background of this study is that curcumin in Curcuma Longa L. is effective in wound healing, but has low bioavailability and is hydrophobic, so a drug delivery system is needed. Drug delivery systems can be carried out in various ways, one of which is by encapsulating curcumin in nanoliposomes. This study aims to determine the effect of nanoliposomes of Curcuma longa extract on wound healing with diabetes mellitus from literature studies. The method used in this study is a systematic literature review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) method. The results of this study are based on the results of a literature review study that has been conducted by researchers, obtained a number of 10 articles, 3 articles discussing the content of curcumin nanoformulation related to wound healing. 4 articles discuss types of curcumin preparations in wound healing. In addition, 3 articles discussed the effect of curcumin on wound healing biomarkers. The conclusion of this study is based on a literature review study that has been conducted by researchers from a number of 10 articles, it can be concluded that some of the contents of Curcuma longa extract have an effect on wound healing with three main biological activities, namely anti- inflammatory, anti-oxidation, and anti-microbial in the presence of re-epithelialization by decreasing the expression of TNF-α, IL- 1β and MMP-9, increasing levels of IL-10, SOD, catalase and glutathione peroxidase, and mobilizing fibroblasts.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0522140012 |
| Uncontrolled Keywords: | curcumin, extract Curcuma longa L., nanoliposom, ulcer, wound healing, curcumin, extract Curcuma longa L., nanoliposome, ulcer, wound healing |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 11 May 2023 04:20 |
| Last Modified: | 11 May 2023 04:20 |
| URI: | http://repository.ub.ac.id/id/eprint/199374 |
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