Wijaya, Ruben Ero Arief and apt. Ema Pristi Yunita,, S.Farm., M.Farm.Klin. and Dr. apt. Valentina Yurina,, S.Si, M.Si. (2022) Systematic Literature Review: Analisis Drug Related Problems pada Pasien Geriatrik dengan Penyakit Diabetes Melitus Tipe 2. Sarjana thesis, Universitas Brawijaya.
Abstract
Indonesia merupakan negara dengan jumlah penderita diabetes terbesar kelima di dunia. Diabetes adalah salah satu penyebab utama kematian di seluruh dunia, terutama di negara berkembang. Drug related problems merupakan suatu keadaan dalam terapi obat yang berpotensi mengganggu target terapi. Pasien dengan penyakit diabetes melitus tipe 2 menerima agen terapi farmakologi yang luas sehingga berisiko tinggi mengalami DRPs yang dapat menimbulkan efek merugikan bagi pasien. Tujuan dari penelitian ini yaitu menganalisis drug related problems yang terjadi pada pasien geriatrik dengan diabetes melitus tipe 2. Penelitian dilakukan dengan teknik systematic literature review, artikel yang diambil dari basis atau jurnal adalah jenis original article dalam rentang tahun 2012-2021 dan terindeks DOAJ (Directory of Open Acces Journal), Scopus dengan nilai minimal kuartil 4 (Q4), PubMed, Science Direct, Research Gate, dan Google Scholar. Sementara itu, untuk jurnal nasional minimal terakreditasi SINTA 2. Berdasarkan hasil penelusuran pustaka didapatkan 15 artikel lalu dilakukan evaluasi. Evaluasi artikel diklasifikasikan berdasarkan nilai evaluasi yaitu kualitas rendah, menengah, dan tinggi. Dari 15 artikel yang dievaluasi menggunakan critical appraisal tools diketahui bahwa lima artikel penelitian memiliki kualitas tinggi, sepuluh artikel penelitian memiliki kualitas menengah, dan tidak ada artikel penelitian yang memiliki kualitas rendah. Keseluruhan hasil dari 15 artikel yang telah dianalisis menunjukkan DRPs yang sering terjadi adalah reaksi efek samping (9 artikel), obat tidak tepat (7 artikel), dan interaksi obat (6 artikel) sedangkan golongan obat yang sering memicu DRPs adalah golongan obat antihipertensi (87%) dan golongan obat antidiabetes (80%).
English Abstract
Indonesia is a country with the fifth largest number of diabetics in the world. Diabetes is one of the leading causes of death worldwide, especially in developing countries. Drug related problems are conditions in drug therapy that have the potential to interfere with the expected therapeutic targets. Patients with type 2 diabetes mellitus receive a wide range of pharmacological therapy agents so that they are at high risk of experiencing DRPs which can have adverse effects on the patient. The purpose of this study is analyze drug related problems that occur in geriatric patients with type 2 diabetes mellitus. The research was conducted using a systematic literature review technique, articles taken from bases or journals were original articles in the 2012-2021 range and indexed by DOAJ (Directory of Open Access Journal), Scopus with a minimum value of quartile 4 (Q4), PubMed, Science Direct , ResearchGate, and Google Scholar. Meanwhile, national journals are at least SINTA 2 accredited. Based on the results of a literature search, 15 articles were found and then an evaluation was carried out. Article evaluation is classified based on the evaluation value, namely low, medium, and high quality. Of the 15 articles evaluated using critical appraisal tools, it was found that five research articles had high quality, ten research articles had medium quality, and none had low quality research articles. The overall results of the 15 articles that have been analyzed show that the most common DRPs are side effect reactions (9 articles), inappropriate drugs (7 articles), and drug interactions (6 articles). While the drug classes that often trigger DRPs are antihypertensive drugs (87%) and antidiabetic drugs (80%).
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0522060356 |
| Uncontrolled Keywords: | Drug Related Problems, Geriatrik, Diabetes Melitus, Reaksi Efek Samping |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Endang Susworini |
| Date Deposited: | 09 May 2023 06:32 |
| Last Modified: | 09 May 2023 06:32 |
| URI: | http://repository.ub.ac.id/id/eprint/199104 |
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