Hakim, dr. Izza Ayudia and dr. Ria Damayanti,, Sp.S (K), M. Biomed and dr. Sri Budhi Rianawati,, Sp.S (K) and Dr. dr. Nanik Setijowati,, M. Kes (2023) Hubungan Kadar High Sensitivity C-Reactive Protein (hsCRP) Dengan Kejadian Vascular Cognitive Impairment (VCI) Pada Pasien Stroke Iskemik Di RSUD dr. Saiful Anwar. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang : Stroke iskemik akut adalah hilangnya aliran darah secara tiba-tiba pada area otak yang menyebabkan hilangnya fungsi neurologis. Hal ini seringkali disebabkan oleh trombus atau emboli yang menyumbat vaskularisasi serebral yang memperdarahai area spesifik di otak. Peningkatan kadar high sensitivity C-Reactive Protein (hsCRP) telah dikaitkan dengan gangguan kognitif dan demensia dalam studi berbasis populasi. Melihat prevalensi gangguan kognitif paska stroke iskemik yang meningkat sehingga penting bagi klinisi untuk mampu melakukan prevensi dan penatalaksanaan terhadap gangguan fungsi kognitif pada pasien stroke. Tujuan Penelitian : Untuk Membuktikan hubungan kadar hsCRP dengan Vascular Cognitive Impairment (VCI) pada pasien yang mengalami stroke iskemik di RSUD Dr. Saiful Anwar. Metode dan Sampel Penelitian : Penelitian ini merupakan penelitian analitik observasional dengan pendekatan crossectional study. Total sampel 23 pasien rawat inap di RSUD dr. Saiful Anwar dari 1 Januari 2022 sampai dengan 31 Januari 2023. Teknik pengambilan sampel menggunakan non-probability sampling jenis purposive sampling. Analisis data menggunakan uji korelasi Spearman, dengan derajat kepercayaan 95% ά=0.05 bermakna bila p < 0.05. Hasil Penelitian : Dari 23 pasien yang menjadi sampel penelitian, diketahui karakteristik usia rata-rata 60.87 tahun, jenis kelamin sebanyak 56.5% pasien pria dan 43.5% pasien wanita, serta pekerjaan paling banyak sebagai wirausaha/wiraswasta 43.5% dan ibu rumah tangga, pensiunan dan tidak bekerja 34.8% untuk pendidikan 26.1% berpendidikan SD dan 34.8% berpendidikan SMA dan yang sederajat. Berdasarkan hasil uji korelasi spearman antara hsCRP dengan Moca-INA, diperoleh nilai koefisien sebesar - 0.501 dengan nilai p sebesar 0.015 (p<0.05). Kesimpulan : Terdapat hubungan yang signifikan antara kadar hsCRP dengan adanya gangguan kognitif berdasarkan kategori skor Moca-INA pada pasien yang mengalami stroke iskemik di RSUD dr. Saiful Anwar.
English Abstract
Background : Acute ischemic stroke is a sudden loss of blood flow to an area of the brain that causes loss of neurological function. This is often caused by a thrombus or embolism that occludes cerebral vessels supplying specific areas of the brain. Elevated levels of high sensitivity C-Reactive Protein (hsCRP) have been associated with cognitive impairment and dementia in population-based studies. Seeing the increasing prevalence of cognitive impairment after ischemic stroke, it is important for clinicians to be able to prevent and manage cognitive dysfunction in stroke patients. Objectives : To determine the relationship between hsCRP levels and Vascular Cognitive Impairment (VCI) in patients who experience ischemic stroke at RSUD dr. Saiful Anwar. Material and Methods : The observational analytic research with a crosssectional study approach. Total sample of 23 patients who were hospitalized at RSUD dr. Saiful Anwar from 1 January 2023 to 31 January 2023. The sampling technique used non-probability sampling with purposive sampling. Data analysis used the Spearman correlation test, with 95% degree of confidence ά=0.05 is significant if p <0.05. Results : From 23 samples, it was known that the characteristics of an average age were 60.87 years, the sex of 56.5% of male patients and 43.5% of female patients, and the most jobs were as entrepreneurs/self-employed 43.5% and housewives, retirees and not work 34.8% for education 26.1% have elementary school education and 34.8% have high school education and the equivalent. Based on the results of the Spearman correlation test between hsCRP and Moca-INA, coefficient value of -0.501 was obtained with a p value of 0.015 (p <0.05). Conclusion : There is a significant relationship between hsCRP levels and cognitive impairment based on the Moca-INA score category in ischemic stroke patients at RSUD dr. Saiful Anwar.
Other obstract
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| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0422060161 |
| Uncontrolled Keywords: | Stroke Iskemik, Vascular Cognitive Impairment (VCI), high sensitivity C-Reactive Protein (hsCRP). |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.8 Diseases of nervous system and mental disorders |
| Divisions: | Profesi Kedokteran > Spesialis Neurologi, Fakultas Kedokteran |
| Depositing User: | Endang Susworini |
| Date Deposited: | 08 May 2023 02:40 |
| Last Modified: | 08 May 2023 02:40 |
| URI: | http://repository.ub.ac.id/id/eprint/198841 |
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