Qomariyah, Elis and Apt. Ayuk Lawuningtyas H. and apt. Dra. Diana Lyrawati (2022) Evaluasi Kepatuhan Dan Keberhasilan Terapi Tamoksifen Pada Pasien Kanker Payudara Di Rumah Sakit Lavalette Malang. Sarjana thesis, Universitas Brawijaya.
Abstract
Kanker payudara merupakan salah satu jenis kanker yang sering terjadi pada perempuan dan penyebab kematian utama di Indonesia maupun dunia. Terapi hormonal tamoksifen merupakan lini pertama untuk pasien kanker payudara dengan status ER+ dan/atau PR+. Untuk keberhasilan terapi, antara lain diperlukan faktor kepatuhan terapi dari pasien. Tujuan penelitian ini untuk mengetahui kaitan antara profil kepatuhan pada masa pandemi COVID- 19, di mana akses fasilitas kesehatan dan mobilitas pasien dibatasi, dan keberhasilan terapi tamoksifen pada pasien kanker payudara dilihat dari angka ketidakkambuhan (Disease Free Survival, DFS). Studi ini dilakukan secara observasional analitik dan cross sectional menggunakan kuesioner dan rekam medik pasien di RS Lavalette Malang. Subyek direkrut secara purposive sampling yang memenuhi kriteria inklusi dan eksklusi pasien dengan k anker payudara yang mendapat terapi tamoksifen pada masa pandemi COVID-19. Hasil penelitian terhadap 100 pasien menunjukkan mayoritas tingkat kepatuhan terapi tamoksifen termasuk pada masa pandemi mayoritas adalah sedang (72%) dan tinggi (28%), dengan efek samping hot flush (53%). Pasien dengan tingkat kepatuhan sedang menunjukkan DFS 0,648, sedangkan tingkat kepatuhan tinggi DFS 0,650, dan secara keseluruhan tanpa membedakan kepatuhan DFS pasien rata-rata 0,631. Hasil uji korelasi menunjukkan korelasi antara kepatuhan terapi tamoksifen dan DFS adalah sedang (r=0,466, p=0,000). Perlu dilakukan penelitian lebih lanjut, antara lain waktu awitan terapi (Time To Initiate) mengapa dengan kepatuhan terapi yang sedang dan tinggi, DFS pasien dengan kanker payudara ER+/PR+ masih lebih rendah dari hasil DFS pasien di negara maju (~0,9)
English Abstract
Breast cancer is a type of cancer that often occurs in women and is the main cause of death in Indonesia and the world. Tamoxifen hormonal therapy is the first line for breast cancer patients with ER+ and/or PR+ status. For the success of therapy, among other factors, the patient's adherence to therapy is needed. This study aimed to find out the link between the adherence profile during the COVID-19 pandemic, where access to health facilities and patient mobility was limited, and the success of tamoxifen therapy in breast cancer patients in terms of the rate of non-recurrence (Disease Free Survival, DFS). This study was conducted in an analytic observational and cross-sectional manner using questionnaires and medical records of patients at Lavalette Hospital Malang. Subjects were recruited by purposive sampling who met the inclusion and exclusion criteria for patients with breast cancer who received tamoxifen therapy during the COVID-19 pandemic. The results of a study of 100 patients showed that the majority of adherence to tamoxifen therapy, including during the pandemic, was moderate (72%) and high (28%), with the side effect of hot flush (53%). Patients with a moderate level of adherence showed a DFS of 0.648, while a high adherence rate of DFS was 0.650, and overall without differentiating patient adherence the average DFS was 0.631. Correlation test results showed that the correlation between adherence to tamoxifen therapy and DFS was moderate (r=0.466, p=0.000). Further research is needed, including the time of onset of therapy (Time To Initiate) why with moderate and high adherence to therapy, the DFS of patients with ER+/PR+ breast cancer is still lower than the DFS results of patients in developed countries (~ 0.9).
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0522060178 |
| Uncontrolled Keywords: | Kepatuhan, Keberhasilan, Disease free-survival, Tamoksifen,-Compliance, Success, Disease free-survival, Tamoxifen. |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Endang Susworini |
| Date Deposited: | 25 Jan 2023 04:30 |
| Last Modified: | 25 Jan 2023 04:30 |
| URI: | http://repository.ub.ac.id/id/eprint/196928 |
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