Hakim, Arif Luqman and Dr. dr. Cesarius Singgih Wahono and Dr. dr. Hani Susianti (2022) Efek Suplementasi Vitamin D3 Dan Kurkumin- Piperin Terhadap Penurunan Kadar Interleukin-6 Dan Skor Mex-Sledai Pada Pasien Lupus Eritematosus Sistemik Dengan Hipovitaminosis-D. Magister thesis, Universitas Brawijaya.
Abstract
Pendahuluan: Hipovitamin D pada pasien LES mengakibatkan derajat aktivitas penyakit lebih berat. Suplementasi vitamin D telah dibuktikan dapat menurunkan derajat keparahan LES, meskipun hasilnya belum memuaskan. Untuk meningkatkan efek dari vitamin D, ditambahkan kurkumin, yakni senyawa ligan alami reseptor vitamin D. Untuk meningkatkan absorbsi kurkumin, dilakukan kombinasi kurkumin dengan piperin. Penelitian ini bertujuan untuk mengetahui penurunan skor MEX- SLEDAI dan kadar IL-6 pada pasien LES setelah suplementasi Vitamin D3 dan kurkumin-piperin. Metode: Empat puluh lima pasien LES wanita dilibatkan dalam double- blind, randomized controlled trial selama tiga bulan. Subjek dibagi menjadi 3 kelompok suplementasi: vitamin D3 3x400 IU dan plasebo 3x1 (kelompok I, n=15), 1x1 tablet kurkumin (600 mg)-piperin (15.800 mg) dan 3x1 tablet plasebo (kelompok II, n=15 ), dan 3x400 IU vitamin D3 dan 1x1 tablet kurkumin (600 mg)-piperin (15.800 mg) (grup III, n=15). Seluruh subjek dievaluasi MEX-SLEDAI dan kadar IL-6 serum pada awal penelitian dan tiga bulan setelah terapi. Hasil Penelitian: Skor MEX-SLEDAI berkurang secara signifikan pada kelompok I (p=0,011), kelompok II (p=0,044), dan kelompok III (p=0,001) setelah perlakuan. Demikian juga IL-6, berkurang secara signifikan pada kelompok I (p=0,017), kelompok II (p=0,003), dan kelompok III (p=0,001) setelah perlakuan. Perubahan skor MEX-SLEDAI (p=0,006) secara bermakna lebih besar pada kelompok III dibandingkan dengan kelompok I atau II. Di sisi lain, perubahan kadar IL-6 serum (p=0,170) paling banyak didapatkan pada kelompok III dibandingkan dengan kelompok I dan II. Kesimpulan: Kombinasi vitamin D dan kurkumin-piperin memiliki hasil terbaik dalam penurunan kadar IL-6 serum dan skor MEX-SLEDAI pada pasien LES
English Abstract
Introduction: Hypovitamin D in LES aggravates the disease activity. Vitamin D supplementation has been shown to reduce SLE severity, although the results have not been satisfactory. To increase the effect of vitamin D, curcumin is added and to increase the absorption of curcumin, a combination of curcumin and piperine is used. This study aims to determine the decrease in in MEX-SLEDAI scores and IL-6 levels in SLE patients after Vitamin D and curcumin-piperine supplementation. Methods: Forty-five female SLE patients were included in a three-month double-blind, randomized controlled trial. Subjects were divided into 3 supplementation groups: vitamin D3 3x400 IU and placebo 3x1 (group I, n=15), 1x1 tablet containing curcumin (600 mg)-piperin (15,800 mg) and 3x1 tablet placebo (group II, n=15), and 3x400 IU of Vitamin D3 and 1x1 tablet containing curcumin (600 mg)-piperin (15,800 mg) (group III, n=15). All subjects were evaluated for MEX-SLEDAI and serum IL-6 levels at study entry and three months after therapy. Results: MEX-SLEDAI scores were significantly decreased in group I (p=0.011), group II (p=0.044), and group III (p=0.001) after treatment. Likewise, IL-6, significantly decreased in group I (p=0.017), group II (p=0.003), and group III (p=0.001) after treatment. The change in MEX- SLEDAI score (p=0.006) was significantly greater in group III compared to group I or II. On the other hand, changes in serum IL-6 levels (p=0.170) were greatest in group III compared to groups I and II. Conclusion: Combination of vitamin D and curcumin-piperin yielded the best results in decrease IL-6 levels and MEX-SLEDAI scores in SLE patients
Other obstract
-
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0422060083 |
| Uncontrolled Keywords: | Lupus Eritematosus Sistemik, Vitamin D, Kurkumin-Piperin, MEX-SLEDAI, IL-6,-Systemic Lupus Erythematosus, Vitamin D, Curcumin- Piperine, MEX-SLEDAI, IL-6 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran |
| Depositing User: | Endang Susworini |
| Date Deposited: | 19 Jan 2023 07:50 |
| Last Modified: | 19 Jan 2023 07:50 |
| URI: | http://repository.ub.ac.id/id/eprint/196785 |
![[thumbnail of DALAM MASA EMBARGO]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text (DALAM MASA EMBARGO)
Arif Luqman Hakim.pdf Restricted to Registered users only until 31 December 2024. Download (5MB) |
Actions (login required)
 |
View Item |