Wintoko, Risal and dr. Hery Susilo,, SpB(K)Onk and dr. Harun Al Rasyid,, MPH (2019) Hubungan Perubahan Reseptor Hormonal, HER-2 Dan KI-67 Setelah Pemberian Kemoterapi Neoadjuvant Berbasis Anthracycline Dengan Hasil Grading Histopatologi Pada Pasien Kanker Payudara Stadium Iii Di Rumah Sakit Saiful Anwar Malang. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Kanker payudara merupakan kanker dengan insiden tertinggi pada wanita di seluruh dunia. Ini juga memiliki angka kematian yang sangat tinggi karena pengobatan yang terlambat. Pengobatan kanker payudara stadium III yang paling umum adalah pemberian kemoterapi neoadjuvant (NACT), yang bertujuan untuk mengurangi ukuran tumor dan mengendalikan metastasis mikro. Pemeriksaan imunohistokimia merupakan faktor penting dalam menentukan subtipe kanker payudara dan terapi selanjutnya. Namun, NACT telah dilaporkan mengubah ekspresi pemeriksaan imunohistokimia Estrogen Receptor (ER), Progesterone Receptor (PR), Human Epidermal Growth Factor Receptor-2 (HER-2), Ki-67 dan grading histopatologi yang diperiksa dari biopsi dan mastektomi. preparat, sehingga subtipe kanker payudara dan grading histopatologinya berubah.Metode: Kami menilai perubahan pemeriksaan imunohistokimia ER, PR, HER-2, Ki-67 dan grading histopatologi dari 59 kasus kanker payudara stadium III setelah pemberian NACT. Kami menganalisis hubungan antara perubahan ekspresi pemeriksaan imunohistokimia pada spesimen jaringan biopsi sebelum pemberian NACT dan dari mastektomi jaringan setelah pemberian NACT terkait dengan grading histopatologinya dengan analisis korelasi spearman.Findings: There were changes in the results of the expression of immunohistochemical examinations of ER, PR, HER-2, KI-67 and histopathological grading by 23.7%, 22.03%, 32.2%, 32.2% and 40.68% in stage III breast cancer patients who received NACT. There was a relationship with a weak correlation between the changes in immunohistochemical examinations of ER, PR, HER-2 and KI-67 with the changes in histopathological grading. The correlation coefficients between ER, PR, HER-2, Ki-67 and the histopathological grading were r=0.265, r=0.317, r=0.352 and r=0.335.Conclusions: Patients with stage III breast cancer who were treated with NACT experienced changes in the expression of immunohistochemical examinations of ER, PR, HER-2 and KI-67 and would experience changes in histopathological grading, causing changes in the breast cancer subtypes. The changes that occur must be interpreted carefully since it will change the subsequent therapy. Therefore, it is necessary to conduct further research on the therapy response to patients who experience changes in the expression.
English Abstract
Background: Breast cancer is a cancer with the highest incidence in women worldwide. It also has a very high mortality due to late treatment. The most common treatment of stage III breast cancer is administration of neoadjuvant chemotherapy (NACT), which aims to reduce tumor size and control micro metastasis. Immunohistochemical examination is an important factor in determining breast cancer subtypes and subsequent therapy. However, NACT has been reported to change the expression of immunohistochemical examinations of Estrogen Receptor (ER), Progesterone Receptor (PR), Human Epidermal Growth Factor Receptor-2 (HER-2), Ki-67 and histopathological grading examined from biopsy and mastectomy preparations, so the breast cancer subtypes and its histopathological grading change. Method: We graded the changes in immunohistochemical examinations of ER, PR, HER-2, Ki-67 and histopathological grading from 59 cases of stage III breast cancer after NACT administration. We analyzed the relationship between the changes in the expression of immunohistochemical examinations on the biopsy tissue specimens before NACT administration and from the tissue mastectomy after NACT administration associated with its histopathological grading with spearman correlation analysis.Findings: There were changes in the results of the expression of immunohistochemical examinations of ER, PR, HER-2, KI-67 and histopathological grading by 23.7%, 22.03%, 32.2%, 32.2% and 40.68% in stage III breast cancer patients who received NACT. There was a relationship with a weak correlation between the changes in immunohistochemical examinations of ER, PR, HER-2 and KI-67 with the changes in histopathological grading. The correlation coefficients between ER, PR, HER-2, Ki-67 and the histopathological grading were r=0.265, r=0.317, r=0.352 and r=0.335. Conclusions: Patients with stage III breast cancer who were treated with NACT experienced changes in the expression of immunohistochemical examinations of ER, PR, HER-2 and KI-67 and would experience changes in histopathological grading, causing changes in the breast cancer subtypes. The changes that occur must be interpreted carefully since it will change the subsequent therapy. Therefore, it is necessary to conduct further research on the therapy response to patients who experience changes in the expression.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.994 49/WIN/h/2019/041910523 |
| Uncontrolled Keywords: | ER, PR, HER-2, KI-67 and histopathological grading |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.9 Other disease > 616.99 Tumors and miscellaneous communicable diseases > 616.994 Cancers > 616.994 49 Breast cancer |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Bedah, Fakultas Kedokteran |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 26 Aug 2022 01:34 |
| Last Modified: | 26 Aug 2022 01:34 |
| URI: | http://repository.ub.ac.id/id/eprint/193603 |
![[thumbnail of Risal Wintoko.pdf]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text
Risal Wintoko.pdf Download (4MB) |
Actions (login required)
 |
View Item |