Ramadhani, Shofi and drg. Ariyati Retno Pratiwi,, M.Kes (2021) Pengaruh Ekstrak Daun Kersen (Muntingia Calabura L.) Sebagai Obat Topikal Berbasis Nanogel Terhadap Penyembuhan Stomatitis: Tinjauan Literatur. Sarjana thesis, Universitas Brawijaya.
Abstract
Latar belakang: Stomatitis merupakan penyakit mulut terbesar ketiga di Indonesia dengan mencapai prevalensi 25-60% dari jumlah populasi dunia. Menurut Riset Kesehatan Dasar Indonesia menunjukkan kenaikan persentase prevalensi penyakit gigi dan mulut sebesar 31,7% dari tahun 2013 sampai 2018. Pada umumnya, obat stomatitis mempunyai kandungan kimia sehingga menyebabkan efek samping yaitu atrofi di mukosa mulut, resistensi obat, dan kandidiasis oral. Saat ini, ekstrak tanaman sedang dikembangkan sebagai obat herbal seperti daun kersen (Muntingia calabura L.). Daun kersen mengandung flavonoid yang dapat menghambat siklooksigenase dan lipoksigenase. Pemilihan sediaan topikal gel dengan teknologi nano bertujuan untuk memaksimalkan kerja flavonoid. Tujuan: untuk mengetahui pengaruh dan mekanisme kerja kandungan daun kersen terhadap siklooksigenase dan lipoksigenase. Metode: pencarian literatur menggunakan diagram PRISMA dengan database Google Scholar, ScienceDirect, NCBI, PubMed, dan Nature sebanyak 429 artikel. Hasil seleksi literatur hanya ditemukan 11 artikel. Hasil: ekstrak daun kersen bermanfaat untuk menghambat enzim siklooksigenase dan lipoksigenase sehingga kerusakan mukosa dapat teratasi. Proses mekanisme kerja dimulai dari penurunan produksi prostaglandin, kemudian mediator COX dan LOX dalam asam arakidonat terhambat. Turunan flavonoid seperti quercetin dapat diubah ke dalam partikel nano berbasis gel sehingga laju difusi obat dapat lebih optimal. Kesimpulan: Ekstrak daun kersen (Muntingia calabura L.) mempunyai pengaruh terhadap siklooksigenase dan lipoksigenase pada stomatitis sebagai antiinflamasi, antioksidan, dan analgesik.
English Abstract
Background: Stomatitis is the third largest oral disease in Indonesia with a prevalence of 25-60% of the world's population. According to the Indonesian Basic Health Research, the proportion of the prevalence of oral and dental diseases increased by 31.7% from 2013 to 2018. In general, stomatitis drugs that contain chemicals that cause side effects are the oral mucosa, drug resistance, and oral candidiasis. Currently, plant extracts are being developed as herbal medicines such as cherry leaves (Muntingia calabura L.). Cherry leaves contain flavonoids which can inhibit cyclooxygenase and lipoxygenase. Selection of topical gel with nano technology aims to maximize the action of flavonoids. Purpose: to see the effect of cherry leaves on the reduction of cyclooxygenase and lipoxygenase and to study the work in the soft tissue healing process. Methods: literature search using PRISMA diagrams with a database of Google Scholar, ScienceDirect, NCBI, PubMed, and Nature are 429 articles. The literature selection results found only 21 articles. Results: Cherry leaf extract is useful for inhibiting cyclooxygenase and lipoxygenase enzymes so that mucosal damage can be resolved. The mechanism process start from a decrease in prostaglandin production, then COX dan LOX mediators in arachidonic acid are inhibited. Flavonoid derivatives such as quercetin can be converted into gel-based particles so that the drug diffusion rate can be optimized. Conclusion: Cherry leaf extract (Muntingia calabura L.) has an effect on cyclooxygenase and lipoxygenase in stomatitis as anti-inflammatory, antioxidant, and analgesic.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0521140042 |
| Uncontrolled Keywords: | daun Muntingia calabura L., nanopartikel, siklooksigenase, lipoksigenase, stomatitis aftosa rekuren,Muntingia calabura L. leaves, nanoparticle, cyclooxygenase, lipoxygenase, recurrent aphthous stomatitis |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 05 Jul 2022 03:38 |
| Last Modified: | 05 Jul 2022 03:38 |
| URI: | http://repository.ub.ac.id/id/eprint/191551 |
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