Salsabila, Dinia Fitri and drg. Ariyati Retno Pratiwi,, M.Kes (2022) Peran Decellurarized Dental Pulp sebagai Kandidat Biomaterial Baru dalam Regenerasi Pulpa: Tinjauan Literatur. Sarjana thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Nekrosis pulpa menjadi salah satu penyakit utama yang paling sering ditemukan pada gigi dan mulut. Perawatan saluran akar merupakan solusi utama untuk nekrosis pulpa, namun pelaksanaaannya dapat menyebabkan kematian gigi dan infeksi berulang. Meregenerasi pulpa dengan mentransplantasikan scaffold, stem cell, dan growth factor pada saluran akar menjadi salah satu alternatif yang dapat ditawarkan untuk mengobati penyakit pulpa dengan mempertahankan gigi tetap vital. Scaffold memainkan perananan penting dalam regenerasi pulpa salah satunya Scaffold ECM berasal dari pulpa yang menggabungkan struktur kolagen mikro bersama dengan molekul bioaktif yang penting untuk regenerasi pulpa gigi dan mampu mendorong diferensiasi serta proliferasi dari stem cell Tujuan: Mengetahui peran Decellularized Dental Pulp sebagai kandidat biomaterial baru dalam regenerasi pulpa. Metode: Systematic literature review dengan menggunakan metode PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses). Hasil dan Pembahasan: Berdasarkan 18 artikel yang dianalisis, decellularized dental pulp scaffold yang diperoleh dari donor hewan maupun manusia dapat mendorong terjadinya proliferasi dan diferensiasi stem cell sehingga dapat digunakan ssebagi scaffold dalam meregenerasi pulpa. Penggunaannya sebagai hydrogel-based scaffold juga dapat mempermudah proses penanaman scaffold sehingga dapat mendorong terjadinya diferensiasi odontoblast-like dan neural-like cells lebih cepat . Berbagai kombinasi decellularized dental pulp scaffold dengan material lain dikembangkan untuk mengoptimalkan regenerasi pulpa. Kesimpulan: Decellurarized Dental Pulp memiliki peran dalam regenerasi pulpa.
English Abstract
Background:Pulp necrosis is one of the main diseases that are most often found in the teeth and mouth. Root canal treatment is the main solution for pulp necrosis, but its implementation can lead to tooth death and recurrent infections. Regenerating the pulp by transplanting scaffolds, stem cells, and growth factors into the root canal is an alternative that can be offered to treat pulpal disease by keeping the teeth vital. Scaffold plays an important role in pulp regeneration, one of which is the ECM scaffold derived from pulp which combines the micro-collagen structure along with bioactive molecules that are important for dental pulp regeneration and are able to promote the differentiation and proliferation of stem cells.Objective: To review the role of Decellularized Dental Pulp as a New Biomaterial Candidate in Pulp Regenerations. Methods: Systematic literature review using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses). Results and Discussion: Based on the 18 articles analyzed, decellularized dental pulp scaffold obtained from animal and human donors can promote stem cell proliferation and differentiation so that it can be used as a scaffold in regenerating the pulp. Its use as a hydrogel-based scaffold can also facilitate the scaffold implantation process so that it can encourage faster differentiation of odontoblast-like and neural-like cells. Various combinations of decellularized dental pulp scaffold with other materials have been developed to optimize pulp regeneration. Conclusion: Decellularized Dental Pulp as a New Biomaterial Candidate has a role in pulp regeneration.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0522140005 |
| Uncontrolled Keywords: | Pulp Regeneration, Decellularized dental pulp, Scaffold, Regenerative Endodontic,Pulp Regeneration, Decellularized dental pulp, Scaffold, Regenerative Endodontic |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Sugeng Moelyono |
| Date Deposited: | 04 Jul 2022 02:09 |
| Last Modified: | 04 Jul 2022 02:09 |
| URI: | http://repository.ub.ac.id/id/eprint/191433 |
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Text (DALAM MASA EMBARGO)
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