Pengaruh Obesitas terhadap Kadar Interleukin-6, Status Faal paru, dan Risiko Obstructive Sleep Apneu

Putra, Christian Surya Eka and Dr. dr. Susanthy Djajalaksana, Sp.P(K) and Dr. dr. Yani Jane Sugiri, Sp.P(K) (2021) Pengaruh Obesitas terhadap Kadar Interleukin-6, Status Faal paru, dan Risiko Obstructive Sleep Apneu. Magister thesis, Universitas Brawijaya.

Abstract

Latar Belakang: Obesitas adalah kondisi peradangan kronis tingkat rendah yang terkait dengan berbagai kondisi medis, seperti peningkatan sitokin inflamasi. Interleukin-6 (IL-6) memainkan peran sentral dalam regulasi inflamasi, hematopoiesis, dan respon imun. IL-6 juga dikaitkan dengan tingkat fungsi paru yang lebih rendah. Penelitian ini bertujuan untuk menganalisis pengaruh obesitas terhadap kadar IL-6, status faal paru, dan risiko OSA. Metode: analitik cross- sectional. Ada 127 peserta dengan 103 peserta obesitas dan 24 peserta non obesitas. Partisipan diwawancarai dengan kuesioner Epworth dan STOP-BANG, skor Epworth > 10 dan skor STOP-BANG 5 mengindikasikan OSA berisiko tinggi. Penilaian fungsi paru menggunakan spirometri, FVC <80% menunjukkan kelainan restriksi dan FEV1/FVC <70% menunjukkan gangguan obstruksi. Kadar serum IL-6 diukur menggunakan kit ELISA. Hasil: Sebanyak 59 partisipan obesitas (46,5%) mengalami gangguan restriksi. Terjadi peningkatan kadar IL-6 pada kelompok obesitas sebesar 221,30 (1.61 - 562.48) pg/dl (p=0,359). Subjek dengan obesitas tipe 3 (5%) memiliki risiko OSA lebih tinggi dengan skor STOP BANG 5 (P = 0,003). Terdapat perbedaan bermakna kadar IL-6 456.94 (3.62 – 542.38) pg/dl pada subjek dengan risiko OSA tinggi dibandingkan dengan risiko rendah dan sedang (P = 0,011). Kadar IL-6 tertinggi pada kelompok partisipan dengan gangguan paru obstruktif sebesar 540.65 (538.94 – 542.38) Kesimpulan: Obesitas menyebabkan peningkatan kadar IL-6, gangguan fungsi paru, dan peningkatan risiko OSA. Peningkatan kadar IL-6 berhubungan dengan gangguan fungsi paru dan peningkatan risiko OSA pada obesitas

English Abstract

Background: Obesity is a chronic low-grade inflammatory condition associated with various medical conditions, such as increase in inflammatory cytokines. Interleukin-6 (IL-6) plays a central role in the regulation of inflammation, hematopoiesis, and immune response. IL-6 is also associated with lower levels of pulmonary function. The study aims to analyze the effect of obesity on IL-6 levels, lung function status, and the risk of OSA. Methods: Cross-sectional analytic. There were 127 participants with 103 obese and 24 non obese participants. Participants were interviewed with the Epworth and STOP-BANG questionnaire, Epworth score >10 and STOP-BANG score ≥5 indicated high risk OSA. Pulmonary function assessment using spirometry, FVC <80% shows restriction abnormalities and FEV1/FVC < 70% indicated obstruction disorders. IL-6 serum levels were measured using the ELISA kit. Results: Total of 59 obese participants (46.5%) had restriction disorders. There was an increase in IL-6 levels in the obese group 221,30 (1.61 - 562.48) pg/dl (p=0.359). Those with type 3 obesity (5%) had a higher risk of OSA with STOP BANG score ≥ 5 (P = 0.003). There were significant difference in IL-6 levels 456.94 (3.62 – 542.38) pg/dl in participants with high risk of OSA compared to low and moderate risk (P = 0.011). Highest IL-6 levels was in the group of participants with obstructive pulmonary disorder of 540.65 (538.94 – 542.38) Conclusion: Obesity leads to increased levels of IL-6, impaired lung function, and an increased risk of OSA. Elevated levels of IL-6 are associated with impaired lung function and an increased risk of OSA in obesity

Item Type:	Thesis (Magister)
Identification Number:	0421060039
Uncontrolled Keywords:	Interleukin-6, Faal Paru, Obesitas, OSA
Subjects:	600 Technology (Applied sciences) > 616 Diseases > 616.2 Diseases of respiratory system > 616.24 Diseases of Lungs / Lungs--Diseases
Divisions:	Profesi Kedokteran > Spesialis Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran
Depositing User:	Budi Wahyono Wahyono
Date Deposited:	13 Jun 2022 07:28
Last Modified:	30 Sep 2024 01:52
URI:	http://repository.ub.ac.id/id/eprint/191059

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