Korelasi Antara Kadar Β-Hydroxybutyrate (Β-Ohb) Dan Kadar Bikarbonat Pada Awal Regulasi Gula Darah Pasien Ketoasidosis Diabetikum Di Rsud Dr. Saiful Anwar

Sari, Titis Wulan (2019) Korelasi Antara Kadar Β-Hydroxybutyrate (Β-Ohb) Dan Kadar Bikarbonat Pada Awal Regulasi Gula Darah Pasien Ketoasidosis Diabetikum Di Rsud Dr. Saiful Anwar. Magister thesis, Universitas Brawijaya.

Abstract

Salah satu komplikasi akut dari diabetes melitus adalah ketoasidosis diabetikum (KAD). KAD ditandai dengan kadar glukosa ≥14mmol/l (≥250mg/dL), asidosis pH <7.3, bikarbonat (HCO3) <18mEq/L, ketonemia, ketonuria. Saat ini di RSUD dr. Saiful Anwar tersedia pemeriksaan β-hydroxybutyrate (β-OHB) menggunakan ketonmeter POCT untuk memfasilitasi klinisi dalam mendiagnosa dan monitoring pasien KAD. Tujuan penelitian untuk menganalisis korelasi antara kadar β-OHB dan HCO3 pada awal regulasi insulin pasien KAD. Metode penelitian menggunakan observasional analitik, cross-sectional yang datanya diambil secara time series. Sebanyak 15 subjek masuk dalam kriteria inklusi. Penelitian menunjukkan ada korelasi antara kadar HCO3 dan β-OHB sesudah awal regulasi insulin (p=0.012 dan r =−0.628). Terdapat perbedaan signifkan kadar HCO3, β- OHB sebelum dan sesudah regulasi insulin dengan nilai p masing-masing 0.001 dan 0.015. Terdapat kesesuaian antara HCO3 dan β-OHB sesudah regulasi insulin (p=0.250). Disimpulkan HCO3 dan β-OHB pada pemberian regulasi awal insulin berkorelasi kuat, sehingga β-OHB dapat digunakan sebagai pengganti HCO3.

English Abstract

One of the acute complications of diabetes mellitus is diabetic ketoacidosis (DKA). DKA is characterized by glucose levels ≥14mmol/l (≥250mg/dL), acidosis pH <7.3, bicarbonate (HCO3) <18mEq/L, ketonemia, ketonuria. Currently in RSUD dr. Saiful Anwar, there is a β-hydroxybutyrate (β-OHB) examination by using a POCT ketone meter to facilitate clinical diagnosis and monitoring of DKA patients. The aim of this research is to analyze the correlation between the level of β-OHB and HCO3 on initial insulin regulation in DKA patients. The research method used is observational analytic, cross-sectional in which the data is retrieved in time series. A total of 15 subjects are included in the inclusion criteria. Research shows that there is a correlation between HCO3 and β- OHB levels after initial insulin regulation (p = 0.012 and r = −0.628). There were significant differences in the levels of HCO3, β-OHB before and after insulin regulation with p-value of 0.001 and 0.015, respectively. There is a match between HCO3 and β-OHB after insulin regulation (p = 0.250). It can be concluded that HCO3 and β-OHB in the administration of initial insulin regulation correlate strongly. Thus, β-OHB can be used instead of HCO3.

Other obstract

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Item Type: Thesis (Magister)
Identification Number: TES/616.462/SAR/k/2019/041906535
Uncontrolled Keywords: ketoasidosis diabetikum, β-hydroxybutyrate (β-OHB), bikarbonat (HCO3), insulin
Subjects: 600 Technology (Applied sciences) > 616 Diseases > 616.4 Diseases of endocrine, hematopoietic, lymphatic, glandular system; diseases of male breast > 616.46 Diseases of islands of Langerhans > 616.462 Diabetes mellitus
Divisions: Profesi Kedokteran > Spesialis Emergensi Medisin, Fakultas Kedokteran
Depositing User: Endang Susworini
Date Deposited: 13 Jun 2022 02:41
Last Modified: 13 Jun 2022 02:41
URI: http://repository.ub.ac.id/id/eprint/191006
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