Hubungan Kadar HbA1c dan Risiko Obstructive Sleep Apnea Syndrome dengan Normal Tension Glaucoma di Kabupaten Malang.

Pratama, Bramantya Surya and Dr.dr. Seskoati Prayitnaningsih,, SpM(K) and dr. Aulia Abdul H,, SpM(K), M.Biomed.Sc, and Dr. Zamroni Afif,, Sp.S (K), M. Biomed and dr. Holipah,, PhD (2021) Hubungan Kadar HbA1c dan Risiko Obstructive Sleep Apnea Syndrome dengan Normal Tension Glaucoma di Kabupaten Malang. Magister thesis, Universitas Brawijaya.

Abstract

TUJUAN: Untuk mengevaluasi korelasi antara HbA1c dan obstructive sleep apnea syndrome (OSAS) dengan normal-tension glaucoma (NTG) di Daerah Pedesaan METODE: Sebanyak 128 responden atau 256 mata dari Desa Sidorahayu, Cepokomulyo, dan Mendalanwangi di Malang, Jawa Timur, Indonesia dilakukan pemeriksaan meliputi usia, jenis kelamin, berat badan, dan tinggi badan. Variabel bebas yang diukur meliputi kadar HbA1c, risiko OSAS yang diukur dengan kuesioner STOP-Bang, pengukuran tekanan darah sistolik/diastolik, dan obesitas yang diukur dengan body mass index (BMI). Variabel dependen yang diukur meliputi NTG, mean defect (MD) yang diukur melalui perimetri serta retinal nerve fiber layer (RNFL), dan cup-to-disc ratio (CDR) vertikal yang diukur melalui optical coherence tomography. Hubungan antar variabel diuji dengan menggunakan uji regresi logistik. HASIL: Tidak ada hubungan antara skor STOP-Bang dengan NTG, MD, RNFL, dan CDR meskipun ketika kami stratifikasi sampel untuk responden obesitas (BMI 30 kg/m²), ditemukan bahwa risiko OSAS yang tinggi memiliki pengaruh yang signifikan terhadap CDR (p = 0,02; ATAU = 4,22). Jika responden memiliki risiko OSAS tinggi, risiko CDR besar empat kali lebih tinggi daripada risiko OSAS ringan. Ada hubungan antara kadar HbA1c tinggi (≥7%) dengan NTG (p = 0,03; OR = 3,33), RNFL (p = 0,04; OR = 2,22), dan CDR (p = 0,05; OR = 2,05). Jika responden menderita diabetes, risiko NTG tiga kali lebih tinggi, risiko penipisan RNFL dua kali lebih tinggi, dan risiko CDR besar dua kali lebih tinggi dari HbA1c normal. Hasil menunjukkan hubungan yang signifikan secara statistik antara BMI dengan NTG dan MD, sistol dengan NTG, dan usia dengan NTG, MD, dan CDR. KESIMPULAN: Responden dengan kadar HbA1c tinggi memiliki peningkatan risiko NTG. Pada responden obesitas, risiko OSAS yang tinggi meningkatkan risiko CDR yang besar. Hubungan antara usia, sistol, dan BMI dengan NTG juga diidentifikasi.

English Abstract

AIM: To evaluate the correlation between HbA1c and the risk of obstructive sleep apnea syndrome (OSAS) with normal-tension glaucoma (NTG) in Rural Area METHODS: A total of 128 respondents or 256 eyes from Sidorahayu, Cepokomulyo, and Mendalanwangi Village in Malang, East Java, Indonesia underwent age, sex, body weight, and height assessments. The independent variables measured included HbA1c levels, OSAS risk measured using the STOP-Bang questionnaire, systolic/diastolic blood pressure measurement, and obesity measured using body mass index (BMI). The dependent variables that were measured include NTG, mean defect (MD) measured via Perimetry as well as retinal nerve fiber layer (RNFL) thickness, and vertical cup-to-disc ratio (CDR) measured via optical coherence tomography. The relationship between variables was tested by using the logistics regression test. RESULTS: There was no relation between STOP-Bang scores and NTG, MD, RNFL, and CDR although when we stratified the sample to obese (BMI ≥30 kg/m²) respondents, it was found that high OSAS risk had a significant effect on CDR (p = 0.02; OR = 4,22). If the respondents have a high OSAS risk, the risk of large CDR is four times higher than the mild OSAS risk. There is a relationship between high HbA1c level (≥7%) and NTG (p = 0,03; OR = 3,33), RNFL (p = 0,04; OR = 2,22), and CDR (p = 0,05; OR = 2,05). If the respondents have diabetes, the risk of NTG is three times higher, the risk of RNFL thinning is two times higher, and the risk of large CDR is two times higher than normal HbA1c. Results show statistically significant relationships between BMI with NTG and MD, systole with NTG, and age with NTG, MD, and CDR. CONCLUSION: Respondents with high HbA1c levels have an increased risk of NTG. In obese respondents, high OSAS risk increased the risk of large CDR. Association between age, systole, and BMI with NTG was also identified.

Item Type:	Thesis (Magister)
Identification Number:	042106
Uncontrolled Keywords:	Glaukoma Tekanan Normal, Obstructive Sleep Apneu Syndrome, HbA1c, Kuesioner STOP-Bang,Normal Tension Glaucoma, Obstructive Sleep Apneu Syndrome, HbA1C, STOP-Bang Questionnaire
Subjects:	600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.7 Ophthalmology
Divisions:	Profesi Kedokteran > Spesialis Ilmu Kesehatan Mata, Fakultas Kedokteran
Depositing User:	Sugeng Moelyono
Date Deposited:	06 Jan 2022 02:59
Last Modified:	09 Oct 2024 04:07
URI:	http://repository.ub.ac.id/id/eprint/187936

Text Bramantya Surya Pratama.pdf Download (2MB)

Actions (login required)

View Item