Purnamasari, Hendike Yuniar and apt. Oktavia Eka P,, M. Sc and apt. Oktavia Rahayu A,, M. Biomed (2021) Systematic Literature Review Pengaruh Mikroemulsi Obat Anti-Inflamasi Non Steroid dalam Basis Gel Terhadap Penetrasi Jumlah Obat Transdermal. Sarjana thesis, Universitas Brawijaya.
Abstract
Obat Anti-Inflamasi Non-Steroid (OAINS) termasuk dalam BCS kelas II yang menunjukkan kelarutan dalam air yang rendah sehingga membatasi formulasi obat dalam bentuk sediaan gel. Penelitian-penelitian terdahulu memformulasikan OAINS dalam bentuk sediaan mikroemulsi yang diinkorporasikan pada basis gel untuk mengoptimalkan pelarutan dan penetrasi pada kulit. Penelitian ini bertujuan untuk menganalisis pengaruh sistem mikroemulsi obat OAINS yang diintegrasikan dalam basis gel terhadap jumlah obat yang terpenetrasi secara transdermal dengan menggunakan sistem gel tanpa mikroemulsi sebagai pembanding. Desain penelitian ini berupa kajian literatur sistematik menggunakan protokol PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) dalam proses seleksi data. Sampel yang digunakan dalam studi ini adalah 12 artikel eksperimental 10 tahun terakhir (2011-2021) yang didapat dari basis data elektronik Scopus, Crossref, PubMed dan Google Scholar dengan menggunakan kata kunci ‘microemulsion AND transdermal AND “anti inflammatory”. Kualitas artikel diuji menggunakan instrumen JBI Checklist for Quasi-Experimental Studies. Hasil penelitian ini menunjukkan bahwa mikroemulsi dalam basis gel meningkatkan jumlah kumulatif zat aktif yang terpenetrasi 1.15 kali sampai 6.28 kali lebih tinggi dan meningkatkan laju penetrasi daripada gel tanpa mikroemulsi karena kemampuan pelarutan OAINS yang lebih tinggi serta adanya komponen minyak, air dan surfaktan pada formulasi dapat mempengaruhi permeabilitas kulit.
English Abstract
Non-Steroid Anti-Inflammatory Drugs (NSAIDs) were included in BCS class II which showed low water solubility thus limiting drug formulation in gel dosage forms. Previous studies formulated NSAIDs in the form of microemulsions incorporated on a gel basis to optimize the dissolution and penetration of NSAIDs into the skin. This study was aimed to analyze the effect of a NSAID microemulsion system integrated into a gel base based on the amount of drug that is transdermally penetrated using a conventional gel system as a comparison. This research design was use a systematic literature review according to the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) protocols for data selection. This study was examined 12 experimental articles from the past 10 years (2011-2021) were obtained from Scopus, Crossref, PubMed and Google Scholar databases using ‘microemulsion AND transdermal AND "anti-inflammatory" for the keywords. The risk of bias was assessed using the JBI Checklist for Quasi-Experimental Studies tool. The results of this study has showed that microemulsion based gel increased the penetration rate and the cumulative amount of active substance penetrated through skin 1.15 times to 6.28 times higher than gels without microemulsion because microemulsion based gel had higher dissolving capacity for NSAID and the present of oil, water and surfactants in the formulation could affect skin permeability.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 0521060178 |
| Uncontrolled Keywords: | Mikroemulsi, transdermal, Obat Anti-Inflamasi Non Steroid. Microemulsion, transdermal, Non Steroid Anti-Inflammatory Drug. |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 22 Dec 2021 03:19 |
| Last Modified: | 24 Feb 2022 02:10 |
| URI: | http://repository.ub.ac.id/id/eprint/187581 |
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