S. Murlistyarini (2021) miRNA-17-5p target prediction and its role in senescence mechanism through p21 interference. Open Access Macedonian Journal of Medical Sciences.
Abstract
BACKGROUND: Cellular senescence is known to be correlated with the cessation of cell cycle. The progression of cell cycle is promoted by activities of various proteins, including cyclin-dependent kinase (CDK) and cyclin proteins, which work synergistically. CDK-cyclin complexes are influenced by other proteins, such as retinoblastoma (Rb) and E2F proteins. In cell cycle, both Rb and E2F proteins could be affected by one of the CDK inhibitors, that is, p21. MicroRNA (miRNA) is well known for its role in biological processes, including cell cycle. However, the contribution of miRNA in cell cycle is still poorly understood. Some miRNAs play a role in pro-proliferation and anti-proliferation.
English Abstract
BACKGROUND: Cellular senescence is known to be correlated with the cessation of cell cycle. The progression of cell cycle is promoted by activities of various proteins, including cyclin-dependent kinase (CDK) and cyclin proteins, which work synergistically. CDK-cyclin complexes are influenced by other proteins, such as retinoblastoma (Rb) and E2F proteins. In cell cycle, both Rb and E2F proteins could be affected by one of the CDK inhibitors, that is, p21. MicroRNA (miRNA) is well known for its role in biological processes, including cell cycle. However, the contribution of miRNA in cell cycle is still poorly understood. Some miRNAs play a role in pro-proliferation and anti-proliferation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cellular senescence, Cyclin-dependent kinase, In silico, miRNA |
| Depositing User: | Endang Susworini |
| Date Deposited: | 16 Dec 2021 03:03 |
| Last Modified: | 16 Dec 2021 03:03 |
| URI: | http://repository.ub.ac.id/id/eprint/187233 |
Actions (login required)
 |
View Item |