Septia Rahmawati Putri, Icha (2021) Literature Review: Uji Efektivitas Daun Pepaya (Carica papaya L.) Terhadap Pertumbuhan Candida albicans. Sarjana thesis, Universitas Brawijaya.
Abstract
"ABSTRAK Latar Belakang: Kandidiasis vaginalis merupakan penyakit pada selaput lendir pada vagina yang menyebabkan keputihan berlebih, gatal dan panas pada area kewanitaan. Sebanyak 70% kasus kandidiasis disebabkan oleh spesies Candida albicans. Penanganan kandidiasis vaginalis yang umum dipakai adalah obat golongan azol. Namun pemakaian antifungi secara berkesinambungan dapat dapat mengganggu keseimbangan flora normal di sekitar vulva vagina, bahkan dapat menyebabkan terjadinya resistensi antifungi. Oleh karena itu, diperlukan pengembangan pengobatan yang lebih aman dan ramah lingkungan. Salah satu pengembangan antifungi yang berasal dari bahan alam adalah penggunaan daun pepaya. Daun pepaya terbukti memiliki aktivitas antifungi dengan menghambat pembentukan dinding sel yang mengakibatkan kebocoran konstituen sitoplasma. Tujuan: Membuktikan adanya efektivitas pemberian daun pepaya (Carica papaya L.) terhadap pertumbuhan Candida albicans berdasarkan hasil penelitian yang telah dilakukan. Metode: Penelitian ini menggunakan desain literature review dengan menggunakan 11 artikel penelitian yang telah bereputasi dalam periode 2010 – 2020. Hasil: Studi terhadap 11 penelitian menunjukkan bahwa daun pepaya (Carica papaya L.) memiliki aktivitas positif dalam menghambat pertumbuhan Candida albicans.. Kesimpulan: Daun pepaya memiliki efektifitas sebagai antifungi terhadap Candida albicans. Aktivitas antifungi ini dipengaruhi oleh senyawa aktif, seperti alkaloid, flavonoid, tanin, saponin, komponen fenol, terpinoid, fitosterol, glikosid, karbohidrat, protein dan asam amino, serta klorofil daun pepaya. Kata kunci: Candida albicans, daun pepaya, kandidiasis vaginalis, keputihan. ABSTRACT Background: Vaginal candidiasis is a disease of the mucous membranes of the vagina that causes excessive vaginal discharge, itching and burning in the female area. As many as 70% of cases of candidiasis are caused by Candida albicans species. Vaginal candidiasis treatment commonly used is azole group of drugs. However, continuous use of antifungals can disrupt the balance of normal flora around the vaginal vulva, and can even lead to antifungal resistance. Therefore, it is necessary to develop safer and environmentally friendly treatments. One of the development of antifungals derived from natural ingredients is the use of papaya leaves. Papaya leaves have been shown to have antifungal activity by inhibiting the formation of cell walls resulting in leakage of cytoplasmic constituents. Aim:To prove the effectiveness of giving papaya leaves (Carica papaya L.) to the growth of Candida albicans based on the results of research that has been done. Methods: This study used a literature review design using 11 reputable research articles in the 2010 – 2020 period. Results: A study of 11 studies showed that papaya leaves (Carica papaya L.) had positive activity in inhibiting the growth of Candida albicans. Conclusion: Papaya leaves have effectiveness as antifungal against Candida albicans. This antifungal activity is influenced by active compounds, such as alkaloids, flavonoids, tannins, saponins, phenolic components, terpinoids, phytosterols, glycosides, carbohydrates, proteins and amino acids, and papaya leaf chlorophyll. Keywords: Candida albicans, papaya leaf, candidiasis vaginalis, vaginal discharge"
English Abstract
Background: Vaginal candidiasis is a disease of the mucous membranes of the vagina that causes excessive vaginal discharge, itching and burning in the female area. As many as 70% of cases of candidiasis are caused by Candida albicans species. Vaginal candidiasis treatment commonly used is azole group of drugs. However, continuous use of antifungals can disrupt the balance of normal flora around the vaginal vulva, and can even lead to antifungal resistance. Therefore, it is necessary to develop safer and environmentally friendly treatments. One of the development of antifungals derived from natural ingredients is the use of papaya leaves. Papaya leaves have been shown to have antifungal activity by inhibiting the formation of cell walls resulting in leakage of cytoplasmic constituents. Aim:To prove the effectiveness of giving papaya leaves (Carica papaya L.) to the growth of Candida albicans based on the results of research that has been done. Methods: This study used a literature review design using 11 reputable research articles in the 2010 – 2020 period. Results: A study of 11 studies showed that papaya leaves (Carica papaya L.) had positive activity in inhibiting the growth of Candida albicans. Conclusion: Papaya leaves have effectiveness as antifungal against Candida albicans. This antifungal activity is influenced by active compounds, such as alkaloids, flavonoids, tannins, saponins, phenolic components, terpinoids, phytosterols, glycosides, carbohydrates, proteins and amino acids, and papaya leaf chlorophyll.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | 052106 |
| Uncontrolled Keywords: | Candida albicans, papaya leaf, candidiasis vaginalis, vaginal discharge |
| Subjects: | 600 Technology (Applied sciences) > 618 Gynecology, obstetrics, pediatrics, geriatrics > 618.2 Obstetrics |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | agung |
| Date Deposited: | 20 Oct 2021 09:30 |
| Last Modified: | 24 Feb 2022 04:22 |
| URI: | http://repository.ub.ac.id/id/eprint/184370 |
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Text (DALAM MASA EMBARGO)
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