Desnawisk, Fadiah (2020) Hubungan Antara Jumlah Leukosit, Neutrofil, dan Limfosit dengan Outcome pada Pasien Sepsis yang Dirawat di Rumah Sakit Dr. Saiful Anwar Malang. Sarjana thesis, Universitas Brawijaya.
Abstract
Insiden kematian sepsis di Indonesia mencapai 44,5%. Pada sepsis terjadi disfungsi organ yang disebabkan oleh adanya disregulasi respon tubuh terhadap infeksi. Kondisi sepsis menyebabkan terjadinya peningkatan neutrofil dan leukosit sebagai respon tubuh terhadap infeksi, dan juga terjadi supresi sistem imun yang menyebabkan limfositopeni. Sehingga jumlah leukosit, neutrofil, dan limfosit akan mengalami perubahan pada sepsis. Penelitian ini bertujuan untuk mengetahui hubungan antara jumlah leukosit, neutrofil, dan limfosit terhadap outcome pasien sepsis. Penelitian ini adalah penelitiain observasional analitik dengan pendekatan kohort prospektif. Jumlah leukosit, neutrofil, dan limfosit diperiksa menggunakan metode flow cytometer. Data dianalisis menggunakan uji korelasi Spearman’s dan Relative Risk. Hasil penelitian ini menunjukan tidak ditemukan perbedaan jumlah leukosit, neutrofil, dan limfosit terhadap mortalitas (p = 0,632, p = 0,246, p = 0,460) maupun syok sepsis (p = 0,054, p = 0,492, p = 0,726). Hasil uji korelasi menunjukan tidak terdapat hubungan antara jumlah leukosit, neutrofil dan limfosit dengan mortalitas (p = 0,636, p = 0,250, p = 0,465) dan syok (p = 0,053, p = 0,498, p = 0,729). Relative Risk leukosit cutoff ≥ 19,025, neutrofil cutoff ≥9,56, dan limfosit cutoff 0,34 terhadap mortalitas adalah 1,28; 1,41; 0,88, sedangkan terhadap syok 9,23; 1,00; 1,75. Kesimpulan dari penelitian ini adalah jumlah leukosit, neutrofil, dan limfosit tidak memiliki hubungan terhadap mortalitas ataupun syok, akan tetapi leukosit dapat menjadi prediktor syok pada pasien sepsis.
English Abstract
Incidence of death in sepsis reaching in 44,5% in Indonesia. In sepsis organ dysfunction occurs due to the dysregulation of the body’s response to an infection. Sepsis can cause an elevation of neuthrophils and leukocyte as a response to infection and also causing a phase of immune suppression which causes lymphocytopenia. This study aims to determine the association between leukocyte, neuthrophils, and lymphocytes with sepsis patient outcomes at Saiful Anwar Hospital Malang. This was an analytic observational with a prospective cohort approach. The number of leukocytes, neutrophils, and lymphocytes was examined using an flow cytometer method. Data analysis is performed with spearman’s correlation test. Then the prognosis test is performed with a 2x2 table. The result showed that no difference in leukocytes, neutrophils, and lymphocytes based on mortality (p = 0,632, p = 0,246, p = 0,460) or sepsis shock (p = 0,053, p = 0,498, p = 0,729) in sepsis patients. There was no association between leukocytes, neutrophils, and lymphocytes with mortality (p = 0,636, p = 0,250, p = 0,465), or sepsis shock (p = 0,053, p = 0,498, p = 0,729). Based on the analysis of Relative Risk between leukocytes cutoff ≥ 19,025, neutrophils cutoff ≥ 9,56, and lymphocytes cutoff ≤0,34 with mortality is 1,28; 1,41; 0,88, and sepsis shock is 9,23; 1,00; 1,75. The conclusion of this study is the leukocytes, neutrophils, and lymphocytes count has no association to mortality or
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2020/44/052003484 |
| Uncontrolled Keywords: | Leukosit, Limfosit, Mortalitas, Neutrofil, Sepsis, Syok Sepsis, Leukocytes, Lymphocytes, Mortality, Neutrophils, Sepsis, Sepsis Shock |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.9 Other disease > 616.94 Bacterial blood diseases > 616.944 Septicemia |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 24 Aug 2020 07:34 |
| Last Modified: | 01 Oct 2024 01:47 |
| URI: | http://repository.ub.ac.id/id/eprint/181390 |
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