Aditya, Raden Rachmad (2020) Pengaruh Pemberian Ekstrak Etanol Daun Kemangi (Ocimum Africanum) Terhadap Skor Integritas Mukosa Lambung Yang Diamati Secara Mikroskopis Pada Lambung Tikus Rattus Norvegicus Strain Wistar Model Ulkus Peptikum Yang Diinduksi Indometasin. Sarjana thesis, Universitas Brawijaya.
Abstract
Penelitian ini bertujuan mengetahui efek ekstrak etanol daun kemangi (Ocimum africanum) terhadap skor integritas mukosa lambung yang diamati secara mikroskopis pada lambung tikus Rattus norvegicus strain wistar model ulkus peptikum yang diinduksi indometasin. 25 wistar jantan dibagi menjadi lima kelompok; kelompok kontrol negatif, kelompok kontrol positif, kelompok perlakuan satu, kelompok perlakuan dua, kelompok perlakuan tiga. Kelompok kontrol positif dan perlakuan diinjeksi dengan indometasin 30 mg/kgBB per oral. Setelah 8 jam paska injeksi indometasin tikus kontrol positif dibedah untuk mengevaluasi pembentukan ulkus pada lambung. Ekstrak etanol daun kemangi diberikan pada kelompok perlakuan dengan tiga dosis berbeda setiap 8 jam selama sehari (150 mg/kgBB, 300 mg/kgBB, 600 mg/kgBB). Sampel diamati untuk melihat integritas mukosa lambung melalui pengamatan mikroskopis perbesaran 400 kali. Hasil penelitian menunjukkan adanya penurunan rerata nilai pada tiga kelompok perlakuan terutama pada kelompok perlakuan dua (0,16) dan tiga (0,12) dibandingkan kelompok kontrol positif (1,2) secara signifikan (p=0,008). Ekstrak etanol daun kemangi (Ocimum africanum) mampu memperbaiki integritas mukosa lambung tikus Rattus norvegicus strain wistar model ulkus peptikum dengan dosis optimal 600 mg/kgBB.
English Abstract
This study aims to determine the effect of ethanol extract of basil leaves (Ocimum africanum) on gastric mucosa integrity score of Rattus norvegicus strain wistar stomach peptic ulcer model induced by indomethacin which observed microscopically. The 25 male wistars are divided into five groups; negative control group, positive control group, treatment group one, treatment group two, treatment group three. The positive control group and treatment groups were injected with indomethacin 30 mg / kg BW orally. 8 hours after indomethacin injection the positive control rat was dissected to evaluate the formation of ulcers in the stomach. Ethanol extract of basil leaves was given to the treatment group with three different doses every 8 hours for a day (150 mg/kgBW, 300 mg/kgBW, 600 mg/kgBW). Samples were observed to see the integrity of the gastric mucosa through microscopic observation of 400 times magnification. The results showed a decrease in the mean value in the three treatment groups, especially in the treatment group two (0.16) and three (0.12) compared to the positive control group (1.2) significantly (p = 0.008). The ethanol extract of basil leaves (Ocimum africanum) was able to improve the gastric mucosal integrity of Rattus norvegicus strain of Wistar strain peptic ulcer model with an optimal dose of 600 mg/kgBW.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2020/33/052003473 |
| Uncontrolled Keywords: | Ulkus Peptikum, Ekstrak Ocimum africanum, Skor Integritas Mukosa Lambung, Indommetasin, Daun Kemangi, Peptic Ulcer, Ocimum africanum Extract, Gastric Mucosa Integrity Score, Indommetachin, Basil Leaves |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 19 Jul 2020 07:38 |
| Last Modified: | 23 Sep 2024 02:35 |
| URI: | http://repository.ub.ac.id/id/eprint/181379 |
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