Arifianingsih, Rininta (2019) Hubungan antara Kadar Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutamic Pyruvic Transaminase (SGPT) dengan Mortalitas Penderita Sepsis yang Dirawat di Rumah Sakit Saiful Anwar Malang. Sarjana thesis, Universitas Brawijaya.
Abstract
Sepsis masih menjadi penyebab utama kematian akibat infeksi di dunia. Angka mortalitas penderita sepsis yang mengalami disfungsi hepar berkisar antara 54-68% yang ditandai dengan peningkatan SGOT dan SGPT. Penelitian ini bertujuan untuk menganalisis hubungan antara SGOT dan SGPT terhadap mortalitas penderita sepsis. Penelitian ini menggunakan metode observasional analitik dengan pendekatan cohort prospektif melalui pengambilan data rekam medis penderita sepsis di Rumah Sakit Saiful Anwar Malang periode November 2018 – April 2019. Data yang diambil meliputi identitas, tanda-tanda vital, hasil pengukuran parameter skor SOFA, diagnosis, kadar SGOT dan SGPT, mortalitas, hasil kultur, dan terapi yang selanjutnya diolah menggunakan software SPSS 24.0. Teknik sampling yang digunakan adalah consecutive sampling sehingga didapatkan 35 subyek penelitian. Hasil uji Mann-whitney didapatkan perbedaan SGOT dan SGPT yang signifikan antara subyek yang hidup dan meninggal (p = 0,004 dan p = 0,011). Hasil uji Spearman menunjukkan terdapat hubungan positif lemah antara kadar SGOT dengan mortalitas (p = 0,001, r = 0,497), begitu pula dengan kadar SGPT (p = 0,004, r = 0,436). Relative Risk (RR) SGOT dengan cut-off 45,5 U/L (AUC = 79,3%, sensitivitas = 78,6% dan spesifisitas = 61,9%), pasien dengan ≥ 45,5 U/L memiliki RR = 1,93 kali mengalami kematian (95% CI : 1,083 – 3,438), sedangkan SGPT dengan cut-off 46,5 U/L (AUC = 75,7%, sensitivitas = 85,7% dan spesifisitas = 61,9%), pasien dengan nilai SGPT ≥ 46,5 U/L memiliki RR = 2,167 kali mengalami kematian (95% CI : 1,223-3,840). Kesimpulan pada penelitian ini yaitu kadar SGOT dan SGPT memiliki hubungan positif lemah dengan mortalitas penderita sepsis.
English Abstract
Sepsis is still as the leading cause of death due to infection worldwide. The mortality rate of sepsis patients with liver dysfunction is up to 54-68% that is marked by the elevation of SGOT and SGPT. This research aims to analyze the correlation between SGOT and SGPT with mortality of sepsis patients. The prospective cohort with observational analytic study was conducted by collecting the sepsis patient medical records in Saiful Anwar Malang Hospital in the period from November 2018 to April 2019. Consecutive sampling was used to determine the research samples. There were 35 patients as research subjects. General characteristics, vital signs, laboratory examination results of SOFA score parameters, diagnosis, SGOT and SGPT tests, mortality, culture result and treatment were recorded and analyzed by SPSS 24.0 software. Mann-whitney test showed that there was significant SGOT and SGPT difference between non-survivor and survivor group (p = 0,004 and p = 0,011), respectively. Spearman correlation test showed a weak positive correlation between SGOT and mortality (p = 0,001, r = 0,497), same with SGPT (p = 0,004, r = 0,436). Relative Risk (RR) of SGOT with 45,5 U/L as the cut-off (AUC = 79,3%, sensitivity = 78,6% and specificity = 61,9%), sepsis patient with SGOT ≥ 45,5 U/L had RR = 1,93 times risk to die, meanwhile SGPT with 46,5 U/L as the cut-off (AUC = 75,7%, sensitivity = 85,7% and specificity = 61,9%), sepsis patient with SGPT ≥ 46,5 U/L had RR = 2,167 times risk to die (95% CI: 1,223 - 3,840). In conclusion, this study showed that there was a weak positive correlation between SGOT and SGPT with the mortality of sepsis patient.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/399/052001244 |
| Uncontrolled Keywords: | sepsis, SGOT, SGPT, mortalitas-sepsis, SGOT, SGPT, mortality |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.9 Other disease > 616.94 Bacterial blood diseases > 616.944 Septicemia |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Sugeng Moelyono |
| Date Deposited: | 10 Aug 2020 07:31 |
| Last Modified: | 22 Oct 2021 07:51 |
| URI: | http://repository.ub.ac.id/id/eprint/179986 |
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