Indriyono, Andhy (2019) Perbandingan Efektifitas Terapi Injeksi Intraartikular Antara Proloterapi Dekstrosa Dengan Triamsinolon Acetonide Pada Pasien Osteoartritis Lutut Derajat Sedang Di Poli Rawat Jalan Neurologi Rsud Dr. Saiful Anwar Malang. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang : Osteoartritis lutut (OA) adalah salah satu gangguan degeneratif tulang rawan yang menjadi masalah utama karena menyebabkan nyeri kronis dan kecacatan. Oleh karena itu metode pengobatan dan pencegahan usia lanjut menjadi tantangan besar. Hasil penelitian terapi Proloterapi Dekstrosa dibandingkan Triamsinolon masih bervariasi. Tujuan penelitian : membandingkan efektifitas Proloterapi Dekstrosa dan Triamsinolon Acetonide (TA) dalam pengobatan OA lutut derajat sedang. Metode : True eksperimental single blind study, di Poliklinik Neurologi Rumah Sakit Dr. Saiful Anwar Malang selama 6 bulan (Juli-Desember 2019). Kelompok I; proloterapi dekstrosa (15%) diinjeksi intraarticular 3 kali setiap 4 minggu dan kelompok II; TA injeksi intraartikular satu kali. Parameter yang diteliti adalah Skor The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Numeric Rating Scale (NRS), dan Range Of Motion (ROM), minggu ke 0, 4, 8, 12 dan 24. Hasil : Empat puluh sampel terdiri dari ; 20 sampel kelompok Proloterapi Dekstrosa terdiri dari ; laki-laki: perempuan = 2 (10%) : 18 (90%), usia 62.4 + 7.28, IMT 25.6 + 3.69 kg/m2, lama nyeri 22.35 + 20.10 bulan, riwayat fisioterapi 40.27 + 20.79 kali. Kellgren–Lawrence osteoarthritis severity grade II; 17(85%), grade III sebanyak 3(15%). Dua puluh sampel kelompok TA; laki-laki: perempuan = 5 (25%):15 (75%), usia 62.5 + 9.02, IMT 28.4 + 5.01 kg/m2, lama nyeri 15.95 + 16.55 bulan, riwayat fisioterapi 34 + 24.87 kali. Kellgren–Lawrence osteoarthritis severity grade II; 18(90%), grade III; 2(10%). Perbandingan NRS Proloterapi Dekstrosa vs TA saat istirahat minggu 4 (2.60 vs 1.25), minggu 8 (1.65 vs 1.40), minggu 12 (0.8 vs 2.05), minggu 24 (0.75 vs 3.35). Perbandingan NRS Proloterapi Dekstrosa vs TA saat aktivitas minggu 4 (4.45 vs 3.35), minggu 8 (3.25 vs 3.55), minggu 12 (2.55 vs 4.30), minggu 24 (2.55 vs 5.80). Perbandingan ROM fleksi Proloterapi Dekstrosa vs TA minggu 4 (127.05 vs 123.60), minggu 8 (130.85 vs 122.95), minggu 12 (130.85 vs 122.95), minggu 24 (131.05 vs 122.10). Perbandingan Skor WOMAC Proloterapi Dekstrosa vs TA minggu 4 (30.05 vs 22.45), minggu 8 (22.90 vs 23.95), minggu 12 (19.30 vs 29.05), minggu 24 (18.95 vs 35.40). Kesimpulan: Injeksi intraartikular Proloterapi Dekstrosa lebih efektif untuk jangka lama berdasarkan skala nyeri NRS, skor WOMAC dan ROM. Sedangkan jangka pendek TA lebih efektif dibandingkan Proloterapi Dekstrosa.
English Abstract
Background: Knee osteoarthritis (OA) is one of the most common cartilage degenerative disorders that is a major problem because it causes chronic pain and disability. Therefore the method of treatment and prevention of old age is a big challenge. The results of Dextrose Prolotherapy compared to Triamcinolone therapy research are still varied. Objective: to compare the effectiveness of Dextrose Prolotherapy and Triamcinolone Acetonide (TA) in the treatment of moderate knee knee OA. Methods: True experimental single blind study, at the Neurology Polyclinic Dr. Saiful Anwar General Hospital Malang for 6 months (July-December 2019). Group I; Dextrose Prolotherapy (15%) intraarticularly injected 3 times every 4 weeks and group II; TA one-time intraarticular injection. The parameters studied were The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Score, Numeric Rating Scale (NRS), and Range of Motion (ROM), weeks 0, 4, 8, 12 and 24. Results: Forty samples consisted of; the 20 samples of the Dextrose Prolotherapy group consisted of; male: female = 2 (10%): 18 (90%), age 62.4 + 7.28, BMI 25.6 + 3.69 kg / m2, pain duration 22.35 + 20.10 months, history of physiotherapy 40.27 + 20.79 times. Kellgren – Lawrence osteoarthritis severity grade II; 17 (85%), grade III 3 (15%). TA group; male : female = 5 (25%): 15 (75%), age 62.5 + 9.02, BMI 28.4 + 5.01 kg/m2, pain duration 15.95 + 16.55 months, history of physiotherapy 34 + 24.87 times. Kellgren – Lawrence osteoarthritis severity grade II; 18 (90%), grade III; 2 (10%). Comparison of NRS at rest Dextrose Prolotherapy vs TA of week 4 (2.60 vs 1.25), week 8 (1.65 vs 1.40), week 12 (0.8 vs 2.05), week 24 (0.75 vs 3.35). Comparison of NRS during activity Dextrose Prolotherapy vs TA week 4 (4.45 vs 3.35), week 8 (3.25 vs 3.55), week 12 (2.55 vs 4.30), week 24 (2.55 vs 5.80). Comparison of ROM flexion Dextrose Prolotherapy vs TA week 4 (127.05 vs 123.60), week 8 (130.85 vs 122.95), week 12 (130.85 vs 122.95), week 24 (131.05 vs 122.10). Comparison of WOMAC score Dextrose Prolotherapy vs TA week 4 (30.05 vs 22.45), week 8 (22.90 vs 23.95), week 12 (19.30 vs 29.05), week 24 (18.95 vs 35.40). Conclusion: Intraarticular Injection Dextrose Prolotherapy is more effective for the long term based on pain scale NRS, WOMAC score and ROM. Whereas short-term TA is more effective than Dextrose Prolotherapy.
Other obstract
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| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.722 3/IND/p/2019/042002040 |
| Uncontrolled Keywords: | OSTEOARTHRITIS, INJECTIONS, INTRA-ORTICULAR, DEXTROSE, TRIAMCINOLONE ACETONIDE |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.7 Diseases of musculoskeletal system > 616.72 Diseases of joints > 616.722 Arthritis > 616.722 3 Osteoarthritis |
| Divisions: | Profesi Kedokteran > Spesialis Neurologi, Fakultas Kedokteran |
| Depositing User: | Endang Susworini |
| Date Deposited: | 05 Mar 2020 07:08 |
| Last Modified: | 02 Dec 2021 06:37 |
| URI: | http://repository.ub.ac.id/id/eprint/179975 |
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