Abdillah, Fauzi (2019) Hubungan Rasio Platelet-Limfosit (RPL), Rasio Neutrofil-Limfosit (RNL), Dan Kadar Serum Deoxyribonucleic Acid (DNA) Virus Hepatitis B Pada Pasien Hepatitis B Kronik. Sarjana thesis, Universitas Brawijaya.
Abstract
Hepatitis B kronik (HBK) merupakan penyakit infeksi kronik pada hati oleh virus Hepatitis B (VHB) yang dapat mengancam jiwa. Sekitar 257 juta jiwa mengidap virus Hepatitis B dan sebanyak satu juta jiwa diantaranya meninggal dunia dikarenakan berkembangnya penyakit menjadi hepatitis kronik, sirosis hati dan karsinoma sel hati (KSH). Untuk mendiagnosis penyakit HBK diperlukan pemeriksaan dari anamnesis hingga pemeriksaan penunjang. Salah satu pemeriksaan penunjang yang biasa dilakukan yaitu dengan menghitung kadar serum Deoxyribonucleic Acid (DNA) VHB untuk mengukur mengukur jumlah virus. Pemeriksaan DNA VHB selain digunakan untuk menunjang diagnosis pada pasien Hepatitis B. Pemeriksaan tersebut terbilang mahal dan tersedia sedikit di Indonesia sehingga diperlukan pemeriksaan lain untuk menjangkau dan meringankan beban pasien terhadap biaya pemeriksaan. Penelitian ini bertujuan mengetahui hubungan RPL, RNL dan kadar serum DNA VHB pada pasien Hepatitis B Kronik. Penelitian cross sectional ini melihat rekam medis pasien hepatitis B kronik usia 17 tahun keatas di RSSA Malang dari Januari 2009 – Desember 2018. Proporsional random sampling dilakukan sesuai dengan kriteria inklusi dan eksklusi sehingga mendapatkan 120 sampel. Nilai RPL dan RNL dihitung berdasar hasil pemeriksaan darah rutin. Kadar serum DNA VHB diapatkan dari pemeriksaan polymerase chain reaction (PCR). Didapatkan nilai rerata RPL pada hepatitis B kronik sebesar 111,56303, RNL sebesar 2,34454, dan kadar serum DNA VHB sebesar 39525036,02. Data diuji dengan uji korelasi metode rank spearman dengan nilai p=0,043 pada korelasi RPL dengan DNA VHB dan nilai p=0,506 pada korelasi RNL dengan DNA VHB. Sehingga dapat disimpulkan penelitian menunjukkan adanya hubungan antara RPL dengan kadar serum DNA VHB pada pasien hepatitis B kronik dan tidak adanya hubungan antara RNL dengan kadar serum DNA VHB pada pasien hepatitis B kronik.
English Abstract
Chronic hepatitis B (CHB) is a chronic infectious disease in the liver by the hepatitis B virus (HBV) which can be life threatening. This disease can have a high risk of death if it develops into liver cirrhosis and hepatocell carcinoma (HCC). Around 257 million people have hepatitis B virus and as many as one milion person has died due to disease progression to chronic hepatitis, liver cirrhosis and HCC. To diagnose CHB requires anamnesis, physical examination, and supporting examination. Investigations that can be done one of them by checking HBV Deoxyribonucleic Acid (DNA) to measure the amount of virus. In addition to being used to support diagnosis, HBV DNA testing is also used to determine the prognosis and measure the therapeutic effect of hepatitis B patients. The examination is fairly expensive and not many health services provide in Indonesia, so other examinations are needed to be able to reach all patients and ease the burden of patients on costs examination. This research aims to know the correlation between PLR, NLR and HBV DNA’s serum levels in Chronic Hepatitis B patients. This cross-sectional study looked at the records of chronic hepatitis B patients aged 17 years and over at RSSA Malang from January 2009 - December 2018. Proporsional random sampling was conducted according to inclusion and exclusion criteria so that 120 samples were obtained. RPL and RNL values are calculated from routine blood tests’s results. HBV DNA’s serum levels were obtained from polymerase chain reaction (PCR) tests. PLR mean in chronic hepatitis B were 111.56303, NLR were 2.334454, and serum levesl of HBV DNA were 39525036.02. This type of analysis use spearman’s rank correlation test with p = 0.043 on PLR correlation with HBV DNA and p = 0.506 on RNL correlation with HBV DNA. So it can be concluded that the research shows an association between RPL with HBV DNA’s serum levels in chronic hepatitis B patients and no relationship between RNL and HBV DNA’s serum levels in chronic hepatitis B patients.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/462/052001286 |
| Uncontrolled Keywords: | HBK, RPL, RNL, kadar serum DNA VHB-CHB, PLR, NLR, HBV DNA’s serum levels. |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.37 Immunologic drugs and immune serums |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 10 Aug 2020 07:41 |
| Last Modified: | 22 Oct 2021 07:00 |
| URI: | http://repository.ub.ac.id/id/eprint/179873 |
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