Rimbawan, Michelle (2019) Pengaruh Kombinasi Ekstrak Air Daun Ciplukan (Physalis angulata L.) dan Albumin terhadap Kadar Trigliserida Tikus Putih (Rattus norvegicus) Strain Wistar Pasca Ovariektomi. Sarjana thesis, Universitas Brawijaya.
Abstract
Pasca menopause merupakan masa dimana wanita akan mengalami penurunan kapasitas reproduksi dalam kehidupan, antara lain terjadinya defisiensi hormon estrogen sehingga kadar trigliserida cenderung lebih tinggi dari pada wanita premenopause. Ciplukan (Physalis) mengandung senyawa fitoestrogen berupa withanolide yang mekanisme kerjanya menyerupai estrogen. Pada wanita pasca menopause, juga terjadi penurunan kadar albumin. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kombinasi ekstrak air daun ciplukan dan albumin dalam berbagai dosis terhadap kadar trigliserida tikus wistar. Tikus dibagi menjadi tujuh kelompok (N: kontrol negatif; OVX 5: terminasi 5 minggu pasca ovariektomi; OVX 9: terminasi 9 minggu pasca ovariektomi; C: terapi ekstrak air daun ciplukan 1500mg/kgBB; D1, D2, D3: terapi ekstrak air daun ciplukan 1500mg/kgBB ditambah albumin dosis 3.3g/kgBB, 6.7g/kgBB, dan 10g/kgBB), semua kelompok perlakuan terapi diterapi selama 4 minggu dan diterminasi pada 9 minggu pasca ovariektomi. Kadar trigliserida diukur dengan metode enzimatis kolometri. Hasil penelitian diuji dengan metode One-way ANOVA dan korelasi pearson. Uji One-way ANOVA tidak menunjukkan perbedaan signifikan antara kadar trigliserida tikus tanpa ovariektomi dengan tikus yang diovariektomi tanpa terapi, maupun antara tikus ovariektomi dengan tikus yang diberi perlakuan terapi. Pada uji korelasi pearson, didapatkan korelasi yang kuat antara penambahan dosis albumin dengan penurunan kadar trigliserida. Dari penelitian ini dapat disimpulkan bahwa pemberian ekstrak air daun ciplukan dengan kombinasi albumin berbagai dosis tidak memberikan pengaruh yang signifikan terhadap kadar trigliserida tikus wistar.
English Abstract
Post menopause is a period where women’s reproductive capacity in life will decrease, including estrogen hormone deficiency which causes triglyceride level to be higher than in premenopausal women. Ciplukan (Physalis) contains phytoestrogen compounds in the form of withanolide whose mechanism of action resembles estrogen. In postmenopausal women, there’s also a decrement in albumin level. The aim of this study is to investigate the effect of ciplukan leaf water extract and albumin combination in various doses on the triglyceride level of wistar rats. The rats were divided into seven groups (N: negative control; OVX 5: 5 weeks post ovariectomy termination; OVX 9: 9 weeks post ovariectomy termination; C: ciplukan leaf water extract treatment 1500mg / kgBB; D1, D2, D3: ciplukan leaf water extract treatment 1500mg/kgBB plus albumin doses of 3.3g/kgBB, 6.7g/kgBB, and 10g/kgBB), all treatment groups were treated in 4 weeks and terminated at 9 weeks post ovariectomy. Triglyceride levels were measured by the enzymatic colometric method. The results of the study were tested by the One-way ANOVA and Pearson correlation method. The One-way ANOVA test does not show significant differences between triglyceride levels in non-ovariectomized rats and ovariectomized rats without treatment, and between ovariectomized rats and treated mice. The Pearson correlation test shows strong correlation between the addition of albumin dosage and decrement in triglyceride level. In conclusion, the administration of ciplukan leaf water extract in combination with albumin in various doses only cause insignificant effect on the triglyceride level in Wistar rats.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/454/052001278 |
| Uncontrolled Keywords: | ekstrak air daun Physalis angulata L., albumin, trigliserida, pasca menopause-Physalis angulata L. leaf water extract, albumin, triglyceride, post menopause |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 19 Jul 2020 07:17 |
| Last Modified: | 22 Oct 2021 07:06 |
| URI: | http://repository.ub.ac.id/id/eprint/179865 |
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