Ludytajati, Ferine (2019) Perbedaan Jumlah Trombosit, Plateletcrit (PCT), Dan Mean Platelet Volume (MPV) Sebagai Biomarker Respon Pengobatan Intensif Obat Anti Tuberkulosis (OAT) Pada Tuberkulosis Anak. Sarjana thesis, Universitas Brawijaya.
Abstract
Tuberkulosis (TBC) anak adalah infeksi yang disebabkan oleh bakteri Mycobacterium tuberculosis. Penurunan inflamasi akibat terapi intensif Obat Anti Tuberkulosis (OAT) 2 bulan dengan Kombinasi Dosis Tetap (KDT) pada TBC anak diharapkan dapat menurunkan Trombosit, meningkatkan Mean Platelet Volume, dan menurunkan Plateletcrit. Akan tetapi perbedaan ketiganya apabila dihubungkan dengan respon pengobatan masih belum diketahui. Penelitian ini merupakan penelitian observasional analitik dengan studi pre dan post dengan subyek berjumlah 24. Hasil penelitian terapi Obat Anti Tuberkulosis (OAT) fase intensif menunjukkan terjadinya penurunan Trombosit yang signifikan (p=0,008), peningkatan Mean Platelet Volume (MPV) yang tidak signifikan (p=0,766), dan penurunan PCT yang signifikan (p=0,015). Pada uji hubungan Trombosit (IK 95%= 0,693-1,023; p=1,000), MPV (IK 95%= 0,691-1,254; p=1,000), dan PCT (IK 95%= 0,678-1,025; p=0,546) dengan perbaikan berat badan didapatkan hasil yang tidak signifikan. Dapat disimpulkan bahwa Ttromrombosit, Mean Platelet Volume, dan Plateletcrit tidak dapat digunakan sebagai biomarker respon pengobatan Tuberkulosis anak.
English Abstract
Tuberculosis (TB) in children is an infection caused by Mycobacterium tuberculosis. Reduction of inflammation due to intensive therapy of Anti Tuberculosis Drugs (OAT) 2 months with a combination of Fixed Doses (KDT) in pediatric Tuberculosis is expected to reduce platelets, increase Mean Platelet Volume, and reduce Plateletcrit. However, the differences between the three when related to the treatment response are still unknown. This study is an observational analytic study with pre and post study which has 24 samples. The data obtained from the medical records. The results of this study before and after the intensive treatment of Anti-Tuberculosis Drug Therapy showed a significant decrease in platelets (p = 0.008), an insignificant increase in Mean Platelet Volume (p = 0.766), and a significant decrease in PCT (p = 0.015). In the relation test of platelet (CI 95%= 0,693-1,023; p=1,000), MPV (CI 95%= 0,691-1,254; p=1,000), dan PCT (CI 95%= 0,678-1,025; p=0,546) with the weight gain are insignificant. It can be concluded that Trombosit, Mean Platelet Volume, and Plateletcrit can’t be used as biomarker response Tuberculosis in children.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/452/052001276 |
| Uncontrolled Keywords: | Tuberkulosis anak, Trombosit, Mean Platelet Volume, Plateletcrit-Tuberculosis in Children, Trombosit, Mean Platelet Volume, Plateletcrit |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.9 Other disease > 616.99 Tumors and miscellaneous communicable diseases > 616.995 Tuberculosis |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Sugeng Moelyono |
| Date Deposited: | 10 Aug 2020 07:44 |
| Last Modified: | 22 Oct 2021 07:08 |
| URI: | http://repository.ub.ac.id/id/eprint/179851 |
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