Agistasari, Yessy (2019) Perbandingan Antara Gel Getah Batang Tanaman Yodium (Jatropha Multifida L.) Dan Gel Aloe Vera Terhadap Kepadatan Serabut Kolagen Pada Penyembuhan Luka Pasca Gingivektomi Tikus Wistar (Rattus Norvegicus). Sarjana thesis, Universitas Brawijaya.
Abstract
Tindakan gingivektomi menyebabkan terjadinya luka sehingga akan melibatkan proses penyembuhan luka pada jaringan. Salah satu tahap penting dari proses penyembuhan luka pasca gingivektomi adalah terbentuknya serabut kolagen. Gel getah batang tanaman yodium (Jatropha multifida L.) memiliki kandungan zat aktif alkaloid, flavonoid, saponin, dan tanin yang berperan dalam proses penyembuhan luka. Aloe vera mengandung tanin dan acemanan yang dapat meningkatkan migrasi makrofag dan mampu mempercepat penyembuhan luka. Tujuan: untuk mengetahui adanya perbedaan antara gel getah batang tanaman yodium (Jatropha multifida L.) dan gel Aloe vera terhadap proses pembentukan serabut kolagen pada penyembuhan luka gingiva pasca gingivektomi. Metode: Subyek penelitian adalah 24 ekor tikus Rat norvegicus dibagi menjadi kelompok kontrol positif (gel Aloe vera), P1 (gel getah batang tanaman yodium 2,5%), P2 (gel getah batang tanaman yodium 5%), P3 (gel getah batang tanaman yodium 10%). Gel uji pada masing-masing kelompok diaplikasikan pada area luka pasca gingivektomi dua kali sehari. Pengamatan proses penyembuhan luka dilakukan pada hari ke-3 dan ke-7 dengan membuat preparat histologi gingiva area luka. Untuk melihat kepadatan serabut kolagen dilakukan pembuatan preparat dengan pengecatan Masson’s Trichrome. Hasil: Hasil uji Kruskall-Wallis menunjukkan tidak adanya perbedaan yang bermakna rerata skor kepadatan serabut kolagen antara kelompok kontrol positif dan kelompok perlakuan (p>0,05). Kesimpulan: tidak terdapat perbedaan antara gel getah batang tanaman yodium (Jatropha multifida L.) dan gel Aloe vera terhadap kepadatan serabut kolagen pasca gingivektomi tikus wistar.
English Abstract
Background: Gingivectomy causes wound that would involve wound healing process on the tissue. One of the important stages of wound healing process after gingivectomy is the formation of collagen fibers. Iodine plant stem sap gel (Jatropha multifida L.) contains bioactive alkaloids, flavonoids, saponins, and tannins which play a role in the process of wound healing. Aloe vera contains tannin and acemanan which can increase the migration of macrophages and can accelerate wound healing. Purpose: to determine the difference between iodine plant stem sap gel (Jatropha multifida L.) and Aloe vera gel on the process of forming collagen fibers in gingival wound healing after gingivectomy. Methodes: The subjects of the study were 24 Rat norvegicus rats divided into positive control groups (Aloe vera gel), P1 (2.5% iodine plant stem sap gel), P2 (iodine plant stem sap gel 5%), P3 (iodine plant stem sap gel 10 %). The test gel in each group was applied to the wound area after gingivectomy twice a day. Observation of the wound healing process was carried out on the 3rd and 7th day by making gingival histology preparations for the injured area. To see the density of collagen fibers, preparations were made by painting Masson’s Trichrome. Result: The Kruskall-Wallis test results showed no significant difference in the mean score of density of collagen fibers between the positive control group and the treatment group (p> 0.05). Conclusion: there is no difference between iodine plant stem sap gel (Jatropha multifida L.) and Aloe vera gel to density of collagen fibers after gingivectomy of wistar rat.
Other obstract
Gingivectomy causes wound that would involve wound healing process on the tissue. One of the important stages of wound healing process after gingivectomy is the formation of collagen fibers. Iodine plant stem sap gel (Jatropha multifida L.) contains bioactive alkaloids, flavonoids, saponins, and tannins which play a role in the process of wound healing. Aloe vera contains tannin and acemanan which can increase the migration of macrophages and can accelerate wound healing. Purpose: to determine the difference between iodine plant stem sap gel (Jatropha multifida L.) and Aloe vera gel on the process of forming collagen fibers in gingival wound healing after gingivectomy. Methodes: The subjects of the study were 24 Rat norvegicus rats divided into positive control groups (Aloe vera gel), P1 (2.5% iodine plant stem sap gel), P2 (iodine plant stem sap gel 5%), P3 (iodine plant stem sap gel 10 %). The test gel in each group was applied to the wound area after gingivectomy twice a day. Observation of the wound healing process was carried out on the 3rd and 7th day by making gingival histology preparations for the injured area. To see the density of collagen fibers, preparations were made by painting Masson’s Trichrome. Result: The Kruskall-Wallis test results showed no significant difference in the mean score of density of collagen fibers between the positive control group and the treatment group (p> 0.05). Conclusion: there is no difference between iodine plant stem sap gel (Jatropha multifida L.) and Aloe vera gel to density of collagen fibers after gingivectomy of wistar rat.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKG/2019/29/052001783 |
| Uncontrolled Keywords: | Jatropha multifida L, Aloe vera, kolagen, penyembuhan luka, gingivektomi-Jatropha multifida L, Aloe vera, collagen, wound healing, gingivectomy |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 21 Feb 2020 02:20 |
| Last Modified: | 23 Oct 2021 04:34 |
| URI: | http://repository.ub.ac.id/id/eprint/179281 |
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