Sintara, Sindu (2018) Pengaruh Pemberian Ketamin terhadap Derajat Inflamasi Mukosa Usus Tikus Model Sepsis. Magister thesis, Universitas Brawijaya.
Abstract
Sepsis dapat mengakibatkan hilangnya pertahanan mukosa usus sehingga menyebabkan translokasi produk bakteri ke dalam sirkulasi darah yang meningkatkan inflamasi pada organ lain. Pemberian ketamin secara intraperitoneal diharapkan dapat menutunkan derajat inflamasi pada mukosa usus yang akan mengurangi terjadinya sepsis sehingga menurunkan morbiditas maupun mortalitas akibat sepsis. Tujuan penelitian untuk mengetahui perbedaan derajat inflamasi dan pengaruh perbedaan waktu pemberian ketamin terhadap derajat inflamasi usus tikus. Penelitian menggunakan metode experimental, dengan sampel hewan coba tikus putih rattus norvegicus dari galur wistar model sepsis menggunakan metode fecal induced peritonitis (FIP). Sampel dibagi menjadi enam kelompok perlakuan yaitu : kontrol negatif (A), kontrol positif (B), pemberian ketamin 5mg/kgbb pada jam ke-0 (C), ke-3 (D), ke-5 (E) dan pemberian berturut-turut pada jam ke 0,2,4 (F). Analisa data menggunakan kruskal wallis dan regresi sederhana. Hasil analisis kruskal wallis diperoleh nilai signifikansi sebesar 0,000 (p<0,05) yang menunjukkan ada perbedaan bermakna antar tiap kelompok perlakuan. Hasil uji regresi didapat nilai koefisien korelasi sebesar 0,730 dan nilai R2 yaitu 0,533 yang menunjukkan waktu pemberian ketamin berpengaruh positif terhadap derajat inflamasi mukosa usus tikus model sepsis. Kesimpulan penelitian menunjukkan waktu pemberian ketamin berpengaruh positif terhadap derajat inflamasi mukosa usus tikus serta terdapat perbedaan derajat inflamasi pada setiap kelompok perlakuan pemberian ketamin
English Abstract
Sepsis can lead to loss of intestinal mucosal defenses resulting in translocation of bacterial products into the blood circulation that increases inflammation in other organs. Intraperitoneally administered ketamine is expected to promote inflammatory degrees in the intestinal mucosa that will reduce the occurrence of sepsis, thus reducing the morbidity and mortality due to sepsis. The aim of this research was to know the difference of inflammation degree and the effect of time difference of ketamine to rat inflammation degree of rat intestine. The study used experimental method, with animal samples of white rattus norvegicus rats from septic wistar strains using the method of fecal induced peritonitis (FIP). The samples were divided into six treatment groups: negative control (A), positive control (B), ketamine 5mg / kgbb on the 0th (C), 3rd (D), 5th (E) hours and consecutive giving - at the hour to 0.2.4 (F). Data analysis using cruciate wallis and simple regression. The result of wallist crucial analysis was obtained by significance value of 0.000 (p <0,05) which showed significant difference between each treatment group. Regression test results obtained correlation coefficient value of 0.730 and R2 value of 0,533 which shows the time of ketamine giving positive effect on inflammatory degree of intestinal mucosa of sepsis model rat. The conclusion of the study showed that the time of ketamine administration had a positive effect on inflammatory degree of mucosa of rat intestine and there were different degree of inflammation in each treatment group giving ketamine
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/615.107 24/SIN/p/2018/041809710 |
| Uncontrolled Keywords: | KETAMINE, INTESTINAL MUCOSA, |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Profesi Kedokteran > Spesialis Anestesiologi dan Terapi Intensif, Fakultas Kedokteran |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 21 Jan 2020 06:47 |
| Last Modified: | 21 Oct 2021 02:11 |
| URI: | http://repository.ub.ac.id/id/eprint/178175 |
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