Muslimah, Amalia Maulida Rara (2019) Efek Terapi Angkak Dari Hasil Fermentasi Beras Terhadap Aktivitas Sgpt Dan Sgot Pada Tikus (Rattus Norvegicus) Model Hiperkolesterolemia. Sarjana thesis, Universitas Brawijaya.
Abstract
Hiperkolesterolemia merupakan meningkatnya kadar kolesterol di dalam darah yang ditandai dengan peningkatan aktivitas Serum Glutamic Piruvat Transaminase (SGPT) dan Serum Glutamic Oxaloacetat Transaminase (SGOT) karena rusaknya sel hepar akibat peroksidasi lipid. Angkak merupakan hasil fermentasi beras yang dapat digunakan sebagai obat hiperkolesterol karena mengandung lovastatin. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian angkak terhadap aktivitas SGPT dan SGOT pada tikus yang diinduksi diet hiperkolesterolemia. Penelitian bersifat eksperimental menggunakan Rancangan Acak Lengkap (RAL). Tikus putih (Rattus norvegicus) sebanyak 20 ekor dibagi menjadi 5 kelompok, yaitu kontrol negatif, kontrol positif (pemberian diet hiperkolestrol), perlakuan 1, 2 dan 3 (pemberian diet hiperkolesterol dan angkak dosis 0,5, 1, dan 1,5 g/ekor/hari). Aktivitas SGPT dan SGOT diukur menggunakan metode spektrofotometri. Analisa Aktivitas SGPT dan SGOT dianalisis dengan one way ANOVA dan uji lanjut dengan Uji Tukey. Hasil penelitian menunjukkan bahwa terapi angkak dapat menurunkan kadar SGPT dan SGOT secara signifikan (P<0,05). Dosis 1,5 g/ekor/hari menunjukkan dosis terbaik dalam menurunkan kadar SGPT sebesar 43,96% dan menurunkan kadar SGOT sebesar 37%. Kesimpulan penelitian ini yaitu angkak dapat menurunkan aktivitas SGPT dan SGOT tikus model hiperkolesterolemia.
English Abstract
Hypercholesterolemia is an increase of cholesterol levels in blood. It will elevate the levels of Serum Glutamic pyruvate Transaminase (SGPT) and Serum Glutamic Oxaloacetat Transaminase (SGOT) due to the damaged of hepatic cells because lipid peroxidation. Angkak is fermentated rice that can be used as a hypercholesterol medication because it contains a compound of lovastatin. The study aimed to determine the influence of the administration of angkak againts SGPT and SGOT in mice-induced hypercholesterolemia diets. The research was an experiment using complete random design (RAL). Twenty rats (Rattus norvegicus) divided into 5 groups, namely negative control, positive control (Hypercholestrol diet), treatment 1, 2 and 3 (administration of Hypercholesterol and angkak dose 0.5, 1, and 1.5 g/rat/day). The activity of SGPT and SGOT were measured using the Spectrophotometry method. Analysis of SGPT and SGOT activity were analyzed with one way ANOVA and advanced test with Test Tukey. The results showed that therapy of angkak can significantly decrease SGPT and SGOT levels (p < 0.05). The dose of angkak 1.5 g/rat/day shows the best dose in decreasing the activity of SGPT rate by 43.96% and the activity of SGOT rate by 37%. The conclusion of this research is angkak can decrease the activity of SGPT and SGOT in rat hypercholesterolemia model.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKH/2019/36/051908974 |
| Uncontrolled Keywords: | Angkak, Hiperkolesterolemia, Monascus purpureus, SGOT, SGPT, Angkak, hypercholesterolemia, Monascus purpureus, SGOT, SGPT |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Fakultas Kedokteran Hewan > Kedokteran Hewan |
| Depositing User: | Nur Cholis |
| Date Deposited: | 19 Jul 2020 05:52 |
| Last Modified: | 21 Oct 2021 03:02 |
| URI: | http://repository.ub.ac.id/id/eprint/176759 |
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