Hanunnida, Afna (2019) Pengaruh Terapi Preventif Ekstrak Kulit Apel Rome Beauty (Mallus Syilvestris Mill) Terhadap Kadar Sgpt Dan Sgot Pada Tikus Putih (Rattus Norvegicus) Yang Diinduksi Plumbum Asetat. Sarjana thesis, Universitas Brawijaya.
Abstract
Plumbum sangat berbahaya bagi makhluk hidup karena menjadi radikal bebas dalam tubuh dan menyebabkan penenekanan sistem antioksidan tubuh, terjadi stres oksidatif serta menyebabkan kerusakan pada organ hati sehingga akan terjadi peningkatan pada SGPT dan SGOT. Senyawa yang dapat mengikat radikal bebas adalah antioksidan yang pada penelitian ini didapat dari ekstrak kulit apel Rome beauty. Tujuan dari penelitian ini adalah menggunakan antioksidan dari ekstrak kulit apel Rome beauty untuk mencegah kenaikan kadar SGPT dan SGOT pada Rattus norvegicus yang diinduksi Pb asetat. Penelitian ini menggunakan lima kelompok tikus putih jantan galur Wistar dengan usia 8-9 minggu dan berat badan 180-200g. Perlakuan yang diberikan yaitu kelompok K- (tanpa induksi Pb asetat dan pemberian ekstrak), K+ (hanya diinduksi Pb asetat 10mg/ekor/hari), P1 (ekstrak kulit apel 28mg/200g selama 7 hari + induksi Pb 10 mg/ekor/hari selama 14 hari), P2 (ekstrak kulit apel 56mg/200g selama 7 hari + induksi Pb asetat 10 mg/ekor/hari selama 14 hari) dan P3 (ekstrak kulit apel 112mg/200g selama 7 hari + induksi Pb asetat 10 mg/ekor/hari selama 14 hari). Pengamatan kadar SGPT dan SGOT dilakukan dengan metode spektrofotometri. Data yang diperoleh akan dianalisa dengan ANOVA probabilitas 5% dan dilanjutkan dengan pola beda nyata jujur (BNJ). Hasil ANOVA menunjukkan bahwa terdapat perbedaan sangat nyata diantara tikus perlakuan (p<0.01). Kesimpulan penelitian ini, ekstrak kulit apel Rome beauty dapat mencegah kenaikan kadar SGPT dan SGOT dengan dosis lebih baik pada kelompok P3 (dosis 112mg/200g).
English Abstract
Lead is very dangerous for living things because it becomes free radicals in the body and causes the suppression of the body's antioxidant system, oxidative stress occurs and causes damage to the liver so that there will be an increase in SGPT and SGOT. Compounds that can bind to free radicals are antioxidants which in this study were obtained from Rome beauty apple skin extract. The purpose of this study is to use antioxidants from Rome beauty apple peel extract to prevent elevated levels of SGPT and SGOT in Rattus norvegicus induced by Pb acetate. This study used five groups of Wistar strain male white rats with ages 8-9 weeks and body weight 180-200g. The treatments given were group K- (without induction of Pb acetate and administration of extract), K+ (only induced Pb acetate 10mg /rat/day), P1 (apple skin extract 28mg/200g for 7 days + Pb acetate 10mg/rat/day for 14 days), P2 (apple skin extract 56mg/200g for 7 days + Pb acetate 10mg/rat/day for 14 days) and P3 (apple skin extract 112mg/200g for 7 days + Pb acetate 10mg/rat/day for 14 days). Observation of SGPT and SGOT levels was carried out by spectrophotometric method. The data obtained will be analyzed with a 5% probability ANOVA and followed by a pattern of Tukey (BNJ). ANOVA results showed that there were very significant differences between the treated rats (p <0.01). The conclusion of this study, Rome beauty apple peel extract can prevent in increasing levels of SGPT and SGOT with better doses in the P3 group (dose 112mg / 200g)
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKH/2019/27/051908965 |
| Uncontrolled Keywords: | radikal bebas, antioksidan, kadar SGPT dan SGOT, free radicals, antioxidants, SGPT and SGOT level |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.321 Drugs derived from plants |
| Divisions: | Fakultas Kedokteran Hewan > Kedokteran Hewan |
| Depositing User: | Nur Cholis |
| Date Deposited: | 19 Jul 2020 05:49 |
| Last Modified: | 21 Oct 2021 02:52 |
| URI: | http://repository.ub.ac.id/id/eprint/176721 |
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