Wiraputra, Bagus Mahendra Satya (2019) Hubungan Lupus Nefritis, Hiponatremia, dan Hipoalbuminemia terhadap Mortalitas pada Pasien Lupus Eritematosus Sistemik di RSUD Dr.Saiful Anwar Malang. Sarjana thesis, Universitas Brawijaya.
Abstract
Lupus Eritematosus Sistemik merupakan penyakit inflamasi kronis yang disebabkan oleh sistem imun menghasilkan antibodi yang menyerang jaringan diri sendiri. Manifestasi klinis yang timbul pada pasien lupus eritematosus sistemik seperti lupus nefritis, hiponatremia, dan hipoalbuminemia. Insidensi kasus baru lupus eritematosus sistemik yang dilaporkan oleh Perhimpunan SLE Indonesia pada tahun 2016 memperoleh rata – rata data dari 8 rumah sakit adalah 10,5. Lupus nefritis mempengaruhi sekitar 60% pasien SLE Hiponatremia terjadi pada 30 dari 100 pasien SLE. Penelitian ini bertujuan untuk mengetahui hubungan antara lupus nefritis, hiponatremia, dan hipoalbuminemia terhadap mortalitas pada pasien lupus eritematosus sistemik di RSUD Dr. Saiful Anwar Malang. Metode yang dilakukan dengan mengumpulkan data pasien SLE yang pernah dirawat di poli reumatologi dan rawat inap RSUD Dr. Saiful Anwar Malang tahun 2013 - 2017. Dalam penelitian ini juga dilakukan wawancara pada pasien SLE yang datang ke Poliklinik Reumatologi dengan tujuan untuk melengkapi data dan didapatkan 373 pasien. Hasil penelitian dianalisis dengan uji deskriptif, uji chi-square dan uji multivariat (regresi logistik biner). Jumlah pasien yang mengalami lupus nefritis sebanyak 255, hiponatremia 158, hipoalbuminemia 185, hiponatremia dan hipoalbuminemia 117, hiponatremia dan lupus nefritis 127, hipoalbuminemia dan lupus nefritis 162, dan pasien yang mengalami ketiganya sebanyak 102. Lupus nefritis tidak mempengaruhi tingkat mortalitas pasien (p=0,119). Hiponatremia, hipoalbuminemia, hiponatremia dan hipoalbuminemia, hiponatremia dan lupus nefritis, hipoalbuminemia dan lupus nefritis, dan kombinasi ketiganya mempengaruhi tingkat mortalitas pasien (p=0,000). Dari hasil uji multivariat yang paling berpengaruh terhadap mortalitas pasien lupus adalah hipoalbuminemia (p=0,000).
English Abstract
Systemic Lupus Erythematous is a chronic inflammatory disease that is caused by the antibody produced from the immune system attacking self healthy tissue. Clinical manifestations that are presented on Systemic Lupus Erythematous are lupus nephritis, hyponatremia, and hypoalbuminemia. New case incidences of Systemic Lupus Erythematous has been reported by Perhimpunan SLE Indonesia in 2016 that the mean from 8 hospitals is 10.5. Lupus nephritic affected about 60% of Systemic Lupus Erythematous patients. 30 out of 100 Systemic Lupus Erythematous patients has been reported that have hyponatremia. The purpose of this research is to investigate the relationship between lupus nephritis, hyponatremia, and hypoalbuminemia towards the mortality of Systemic Lupus Erythematous patients in RSUD Dr. Saiful Anwar Malang. The method that has been used in this research by collecting data of Systemic Lupus Erythematous patients that have been treated in rheumatology center of RSUD Dr. Saiful Anwar Malang from 2013 – 2017. Another method that has been used in this research by interviewing Systemic Lupus Erythematous patient from the rheumatology center to complete the data. From the data collected, 373 patients are diagnosed with Systemic Lupus Erythematous. Descriptive and chi-square test has been used to analyze in this research. The number of patients who diagnosed with lupus nephritis is 255, hyponatremia 158, hypoalbuminemia 185, hyponatremia and hypoalbuminemia 117, hyponatremia and lupus nephritis 127, hypoalbuminemia and lupus nephritis 162, and patients who have all of three conditions about 102. After the analyses, lupus nephritis did not affect to mortality of Systemic Lupus Erythematous patients (p=0,119), while hyponatremia and hypoalbuminemia affected to mortality of Systemic Lupus Erythematous patients (p=0,000). From the results of multivariate tests, the most affected to mortality of Systemic Lupus Erythematous patients is hypoalbuminemia (p=0,000).
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/303/051909423 |
| Uncontrolled Keywords: | Lupus Eritematosus Sistemik, lupus nefritis, hiponatremia, hipoalbuminemia, Systemic Lupus Erythematous, lupus nephritis, hyponatremia, hypoalbuminemia |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.7 Diseases of musculoskeletal system > 616.77 Diseases of connectives tissues > 616.772 Systemic lupus erythematosus |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 05 Aug 2020 07:47 |
| Last Modified: | 25 Oct 2021 02:15 |
| URI: | http://repository.ub.ac.id/id/eprint/176182 |
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