Puspitasari, Fadhyla Widya (2019) Pengaruh Variasi Konsentrasi Kombinasi Surfaktan Tween 80 dan Span 80 terhadap Karakteristik Solid-Lipid Nanopartikel Pterostilben. Sarjana thesis, Universitas Brawijaya.
Abstract
Kulit merupakan organ yang memiliki fungsi pertahanan tubuh terhadap paparan sinar UV B yang diketahui memiliki efek induksi stres oksidatif penyebab munculnya penuaan dini dan kanker kulit. Pterostilben memiliki sifat antioksidan yang dapat mencegah dampak kronis UV B melalui modulasi respon antioksidan di epidermis kulit sehingga sistem pembawa obat lipofil, solid-lipid nanopartikel (SLN), dapat dimanfaatkan sebagai sistem pembawa pterostilben dengan harapan pterostilben akan terkonsentrasi pada epidermis sekaligus SLN memblokir UV secara fisik. Untuk mendapatkan efikasi tabir surya, karakteristik ideal tabir surya perlu dipenuhi, sementara dalam penerapan SLN, penggunaan surfaktan diduga dapat berpengaruh atas ketercapaian karakteristik tersebut. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi kombinasi surfaktan tween 80 dan span 80 terhadap karakteristik SLN Pterostilben. SLN dibuat berdasarkan metode hot homogenization dan konsentrasi kombinasi surfaktan yang digunakan adalah 5%, 7,5%, dan 10%. Karakterisasi organoleptik, homogenitas fisik, nilai pH, daya sebar, daya lekat, viskositas, ukuran partikel, indeks polidispersitas, dan potensial zeta dievaluasi dan dilakukan analisis statistik menggunakan uji One Way ANOVA dan uji Post- Hoc Tukey’s HSD. Hasil penelitian menunjukkan bahwa variasi konsentrasi kombinasi surfaktan tween 80 dan span 80 tidak mempengaruhi karakteristik organoleptik, homogenitas fisik, nilai pH, dan potensial zeta, tetapi mempengaruhi karakteristik viskositas, daya sebar, daya lekat, ukuran partikel, dan indeks polidipersitas. Selain itu, variasi konsentrasi kombinasi surfaktan tween 80 dan span 80 di atas 7,5% akan berpengaruh terhadap peningkatan ukuran partikel SLN.
English Abstract
Skin provides defense function against UV B radiation which responsible for oxidative stress induction and leads to premature aging and skin cancer. Pterostilbene has antioxidant properties that can prevent chronic effects of UV B through modulation of antioxidant responses in epidermis so that the use of lipophilic drug carrier systems, SLN, can be used as a pterostilbene carrier system and also be expected that pterostilbene will be concentrated in the epidermis while SLN physically blocking UV. To obtain the efficacy of sunscreen, the ideal characteristics of sunscreen need to be fulfilled, while in SLN application, a surfactant is supposed to have an effect on the achievement of these characteristics. The aim of this study was to investigate the effect of combination surfactant concentration tween 80 and span 80 on SLN’s characteristic. SLN was made by hot homogenization method and concentration combination tween 80 and span 80 used were 5%, 7,5%, and 10%. Characterization of organoleptic, physical homogeneity, pH value, spreadability, adhesive activity, viscosity, particle size, polydispersity index, and zeta potential was evaluated. Statistical analyses were performed using One Way ANOVA test and Tukey's HSD post-hoc test. The results showed that variation concentration of tween 80 and span 80 did not affect organoleptic characteristics, physical homogeneity, pH value, and zeta potential, but affect to viscosity, spreadability, adhesive activity, particle size, and polydispersity index. In addition, concentration of tween 80 and span 80 combinations above 7.5% will increase particle size of SLN.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/368/051909511 |
| Uncontrolled Keywords: | sistem pembawa obat, surfaktan, tabir surya. drug carrier system, sunscreen, surfactant. |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.5 Diseases of integument / Skin--Diseases > 615.506 Skin--Diseases--Treatment |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 26 Aug 2020 04:29 |
| Last Modified: | 25 Oct 2021 03:40 |
| URI: | http://repository.ub.ac.id/id/eprint/175457 |
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