Ula, Ade Zaqiatul Rohmatil (2019) Uji Beda Efek Samping Penggunaan Bisfosfonat Melalui Rute Oral, Injeksi Intravena, dan Infus Pada Pasien Osteoporosis. Sarjana thesis, Universitas Brawijaya.
Abstract
Bisfosfonat merupakan golongan obat yang paling banyak digunakan dalam terapi osteoporosis. Pada post marketing, dilaporkan adanya kejadian efek samping pada saluran cerna bagian atas akibat iritasi lokal khususnya setelah penggunaan bisfosfonat oral. Efek samping flu-like syndrome terjadi pada penggunaan bisfosfonat dengan rute parenteral. Penelitian ini bertujuan mengetahui kejadian efek samping akibat penggunaan bisfosfonat pada rute oral, injeksi intravena, dan infus. Studi analisis deskriptif kuantitatif menggunakan metode cross sectional dilakukan terhadap pasien osteoporosis sampel penelitian ini. Sampel dipilih berdasarkan kriteria inklusi, kemudian dilakukan wawancara terhadap pasien dengan menggunakan algoritme NARANJO. Penelitian ini telah dinyatakan laik etik dengan nomor surat 400/082/K.3/302/2019. Hasil penelitian menunjukkan bahwa kejadian efek samping berupa gangguan saluran pencernaan (26,1%) terjadi pada kelompok sampel yang menggunakan bisfosfonat rute oral, sedangkan sampel yang menggunakan bisfosfonat rute injeksi intravena dan infus mengalami flu-like syndrome masing-masing 4,3% dan 8,7%. Dari penelitian ini dapat disimpulkan bahwa, terdapat perbedaan gejala efek samping akibat penggunaan bisfosfonat dengan rute oral, injeksi intravena, dan infus.
English Abstract
Bisphosphonates are the most widely used class of drugs in osteoporosis therapy. In post marketing, there is a reported incidence of upper gastrointestinal side effects due to local irritation especially after the use of oral bisphosphonates. Side effects of flu-like syndrome occur in the use of bisphosphonates on the parenteral route. This study aims to determine the incidence of side effects due to the use of bisphosphonates on different administration routes. The descriptive quantitative analysis study used a cross sectional method conducted on osteoporosis patients in this study. Samples were selected based on inclusion criteria. Interviews were conducted with patients using NARANJO Algorithm. This study has benn stated as ethical conduct by letter number: 400/082/K.3/302/2019. The results showed that the incidence of side effects in the form of digestive tract disorders (26.1%) occurred in the sample group using bisphosphonates on the oral route, while samples using bisphosphonates with intravenous injection and infusion routes had flu-like syndrome (4,3% and 8,7% respectively). From this study it can be concluded that, there are differences in symptoms of side effects from the use of bisphosphonates on different routes (oral, intravena injection, and infusion).
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/237/051909320 |
| Uncontrolled Keywords: | osteoporosis, bisfosfonat, efek samping, saluran pencernaan, flu-like syndrome |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 26 Aug 2020 04:28 |
| Last Modified: | 22 Oct 2021 03:14 |
| URI: | http://repository.ub.ac.id/id/eprint/175404 |
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