Umamah, Safira Naafi (2019) Pengaruh Pemberian Ekstrak Etanol Brokoli (Brassica oleracea) Terhadap Berat Plasenta Tikus (Rattus norvegicus) Bunting Yang Terpapar Asap Rokok. Sarjana thesis, Universitas Brawijaya.
Abstract
Asap rokok mengandung banyak radikal bebas yang berbahaya bagi perkembangan janin serta dapat merugikan pada kehamilan yang mengakibatkan terganggunya fungsi plasenta. Paparan asap rokok selama kehamilan akan semakin meningkatkan jumlah ROS (Reactive Oxygen Species) dalam tubuh sehingga resiko stres oksidatif akan meningkat. Radikal bebas dapat ditanggulangi, salah satunya menggunakan brokoli yang banyak mengandung antioksidan flavonoid. Tujuan dari penelitian ini untuk mengetahui pengaruh pemberian ekstrak etanol brokoli terhadap berat plasenta tikus yang terpapar asap rokok. Metode penelitian ini adalah Randomized Post Test Only Control Group yang terdiri dari 2 kelompok kontrol (K-, K+) dan 3 kelompok dengan ekstrak etanol brokoli 100mg/kgBB, 200mg/kgBB, dan 400mg/kgBB. Analisis hasil dalam penelitian ini menggunakan metode One Way ANOVA dengan p-value (0,004). Hasil pengujian dengan Post Hoc dilakukan untuk mengetahui kelompok mana yang mempunyai berat plasenta yang berbeda signifikan. Berdasarkan pengujian Post Hoc didapatkan bahwa hasil perbandingan K (+) dengan K (-) diperoleh p = 0,012 yang berarti ada perbedaan secara bermakna. Setelah diberi ekstrak etanol brokoli 200mg/kgBB dan 400mg/kgBB, rerata berat plasenta meningkat secara signifikan (p<0,05). Berdasarkan hasil penelitian, disimpulkan bahwa pemberian ekstrak etanol brokoli terbukti meningkatkan berat plasenta tikus yang terpapar asap rokok.
English Abstract
Cigarette smoke contains many harmful free radicals for fetal development and can be detrimental to pregnancy which results in disruption of the function of the placenta. Exposure to cigarette smoke during pregnancy will increase the amount of ROS (Reactive Oxygen Species) in the body so that the risk of oxidative stress will increase. Free radicals can be handled, one of which uses broccoli which contains a lot of flavonoid antioxidants. The purpose of this study was to determine the effect of giving broccoli ethanol extract to placental weight of rats exposed to cigarette smoke. The method of this research was Randomized Post Test Only Control Group consisting of 2 control groups (K-, K +) and 3 groups with broccoli ethanol extracts of 100mg/kgBW, 200mg/kgBW, and 400mg/kgBW. The administration of broccoli ethanol extract started from 1-19 days, while exposure to cigarette smoke began on the 7-19th day of pregnancy. The analysis of the results in this study using the One Way ANOVA method with p-value (0,004). Post Hoc test results were conducted to determine which groups had significantly different placental weights. Based on the Post Hoc test it was found that the results of the K (+) comparison with K (-) were obtained p = 0.012 which meant that there were significant differences. After being given 200mg / kgBW and 400mg / kgBW of broccoli ethanol extract, the placental weight increased significantly (p <0,05). Based on the results of the study, it is concluded that the administration of broccoli ethanol extract was shown to increase the placental weight of rats exposed to cigarette smoke.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/214/051909295 |
| Uncontrolled Keywords: | Asap Rokok, Ekstrak Brokoli, Plasenta, Cigarette Smoke, Broccoli Extract, Placenta |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 19 Jul 2020 04:53 |
| Last Modified: | 14 Mar 2022 03:59 |
| URI: | http://repository.ub.ac.id/id/eprint/175364 |
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