Nurfadhilah, Ziana Zain (2019) Pengaruh Pemberian Ekstrak Etanol Kulit Apel Manalagi (Malus sylvestris Mill) dalam Mencegah Penurunan Kadar Hemoglobin (Hb) pada Tikus (Rattus norvegicus) Bunting yang Dipapar Asap Rokok. Sarjana thesis, Universitas Brawijaya.
Abstract
merokok merupakan perilaku yang sering dijumpai di berbagai tempat dan dianggap sebagai kebiasaan dalam masyarakat. Gangguan kesehatan dapat terjadi akibat bahan berbahaya yang dikandung oleh asap rokok seperti monoksida, timbal dan radikal bebas, dampak dari paparan asap rokok dapat menyebabkan terjadinya anemia pada kehamilan. Tujuan: Membuktikan pemberian ekstrak etanol kulit apel manalagi dapat mencegah penurunan kadar Hb tikus bunting yang dipapar asap rokok. Metode: Rancangan penelitian ini adalah Randomized Post Test Only Control Grup design, dengan membandingkan kadar Hb antar kelompok perlakuan, dibagi menjadi 5 kelompok yaitu K- adalah tikus bunting yang tanpa dipapar asap rokok dan tanpa diberikan ekstrak etanol kulit apel. K+ adalah tikus bunting yang hanya dipapar asap rokok tanpa diberikan ekstrak etanol kulit apel. P1 (7 mg/KgBB), P2 (14 mg/KgBB), dan P3 (28 mg/KgBB) adalah dipapar asap rokok dan diberikan ekstrak etanol kulit apel dengan dosis yang berbeda. Paparan asap rokok dan pemberian ekstrak etanol kulit apel dilakukan mulai hari ke 6-18 kebuntingan. Pengukuran kadar Hb dilakukan pada hari ke-19 kebuntingan. Data dianalisis dengan One way Anova dilanjutkan dengan Post hoc, untuk mengetahui hubungan maka dilakukan uji Korelasi Pearson. Hasil: Penelitian menunjukkan bahwa kadar Hb pada kelompok K+ lebih kecil dibanding K-, sedangkan P1 lebih besar dibanding K+ tetapi tidak berbeda bermakna, P2 dan P3 lebih besar dibanding K+ secara bermakna, namun tidak berbeda bermakna dengan K-. Kesimpulan: Penelitian ini menunjukkan dosis yang efektif dalam pemberian ekstrak etanol kulit apel manalagi yang dapat mencegah penurunan kadar hemoglobin yaitu 14 mg/KgBB dan 28 mg/KgBB.
English Abstract
smoking is a behavior that is often found in various places and is considered as a habit in society. Health problems can occur due to hazardous substances contains in cigarette smoke such as monoxide, lead and free radicals, the effects of exposure to cigarette smoke can cause anemia in pregnancy. Objective: To prove that the administration of manalagi apple ethanol extract can prevented a decrease in Hb levels in pregnant mice due to exposure to cigarette smoke. Method: The design of this study was a randomized post test only control group design, by comparing Hb levels between treatment groups, divided into 5 groups, namely K- was pregnant mice without exposure to cigarette smoke and without the ethanol extract of apple skin. K + was a pregnant mouse exposed to cigarette smoke without the ethanol extract of apple skin. P1 (7 mg / KgBB), P2 (14 mg / KgBB), and P3 (28 mg / KgBB) were exposed to cigarette smoke and given ethanol extract of apple skin at different doses. Exposure to cigarette smoke and the administration of ethanol extract from apple peel were carried out from the 6-18th day of pregnancy. Hb level measurement was carried out on the 19th day of pregnancy. Data was analyzed by One way ANOVA followed by Post hoc, to find out the relationship, Pearson Correlation was tested. Results: The study showed that Hb levels in the K + group were smaller than K-, whereas P1 was greater than K + but did not differ significantly, P2 and P3 were greater than K + significantly, but not significantly different from K-. Conclusion: This study shows an effective dose in the administration of ethanol extract of manalagi apple skin which can prevent a decrease in hemoglobin levels of 14 mg/KgBB and 28 mg/KgBB.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/270/051909448 |
| Uncontrolled Keywords: | ekstrak etanol kulit apel, asap rokok, hemoglobin, dan tikus bunting, apple skin ethanol extract, cigarette smoke, hemoglobin, and pregnant rats |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 19 Jul 2020 04:53 |
| Last Modified: | 25 Oct 2021 03:09 |
| URI: | http://repository.ub.ac.id/id/eprint/175355 |
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