Hayati, Fathan (2019) Pengaruh Pemberian Ekstrak Etanol Kulit Apel Manalagi (Malus sylvestris Mill) dalam Mencegah Peningkatan Kadar Serum LDL (Low Density Lipoprotein) pada Tikus (Rattus norvegicus) Bunting yang Dipapar Asap Rokok. Sarjana thesis, Universitas Brawijaya.
Abstract
jumlah perokok diperkirakan semakin meningkat setiap tahun, rokok mengandung radikal bebas yang berbahaya bagi kesehatan sehingga dapat menyebabkan perubahan pada metabolisme lipid. Tujuan: untuk membuktikan ekstrak etanol kulit apel manalagi dapat mencegah peningkatan kadar LDL tikus bunting yang dipapar asap rokok. Metode: penelitian ini menggunakan rancangan Randomized Post Test Only dengan membandingkan kadar LDL antar kelompok, dibagi menjadi 5 kelompok yaitu: K(-) tanpa paparan asap rokok dan tanpa ekstrak etanol kulit apel; K(+) paparan asap rokok tanpa ekstrak etanol kulit apel; Perlakuan, yaitu [P1 (7mg/KgBB), P2 (14mg/KgBB), P3 (28mg/KgBB)] dan paparan asap rokok. Paparan asap rokok dan ekstrak etanol kulit apel diberikan pada hari 6-18 kebuntingan. Hari ke-19 dilakukan pengukuran kadar serum LDL. Data dianalisis dengan ANOVA, dilanjutkan dengan Post Hoc Tukey, dan untuk melihat hubungan maka dilakukan uji korelasi. Hasil: hasil penelitian menunjukan bahwa kadar serum LDL pada kelompok K(+) lebih besar dari K(-) secara bermakna, sedangkan P1 dan P2 lebih kecil dari K(+) namun tidak berbeda makna, P3 lebih kecil dari K(+) secara bermakna. Kesimpulan: dosis efektif pemberian ekstrak etanol kulit apel manalagi yang mampu mencegah peningkatan kadar serum LDL adalah dosis 28 mg/KgBB.
English Abstract
the number of smokers is estimated to increase every year, cigarettes contain free radicals which are harmful to health, so it can cause changes in lipid metabolism. Objective: to prove the ethanol extract of Manalagi apple peel can prevent an increase in LDL levels in pregnant rat exposed to cigarette smoke. Method: This study used a randomized post test only design by comparing LDL levels between groups, divided into 5 groups: K(-) without exposure to cigarette smoke and without ethanol extract of apple peel; K(+) exposure to cigarette smoke without ethanol extract of apple peel; ethanol extract of apple peel [P1 (7mg/KgBB), P2(14mg/KgBB), P3 (28mg/KgBBB)] and exposure to cigarette smoke. This Exposure of cigarette smoke and ethanol extract of apple peel is given on 6-18 days of pregnancy, day 19 measured serum levels of LDL. Data were analyzed by ANOVA, followed by Post Hoc Tukey, to see the relationship between groups a correlation test was conducted. Results: The results of the study showed that serum LDL levels in the K(+) group were significantly greater than K(-), while P1 and P2 were smaller than K(+) but did not differ in meaning, P3 was smaller than K(+) meaningful. Conclusion: the effective dose of ethanol extract of manalagi apple peel which was able to prevent an increase in serum LDL levels was a dose of 28 mg/KgBB.
Other obstract
-
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/176/051909343 |
| Uncontrolled Keywords: | ekstrak etanol kulit apel, asap rokok, LDL, dan tikus bunting, cigarette smoke, ethanol extract of apple skin, LDL, pregnant rat |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 19 Jul 2020 04:47 |
| Last Modified: | 14 Mar 2022 02:13 |
| URI: | http://repository.ub.ac.id/id/eprint/175303 |
Preview |
Text
Fathan Hayati.pdf Download (4MB) | Preview |
Actions (login required)
 |
View Item |