Nasution, Ramadhini Puspita (2019) Pengaruh Diet Tinggi Kolesterol Terhadap Kadar Glukosa Darah Tikus (Rattus norvegicus) Bunting. Sarjana thesis, Universitas Brawijaya.
Abstract
Diabetes melitus gestasional merupakan keadaan glukosa darah tinggi pada ibu hamil. Diabetes melitus gestasional memiliki dampak buruk terhadap ibu dan janin seperti, persalianan secara sesar, bayi makrosomia, distosia bahu saat persalinan dan kematian bayi. Diabetes terjadi karena adanya ganggguan metabolisme glukosa dan menyebabkan resistensi insulin, resistensi insulin berhubungan erat dengan peningkatan kolesterol. Seseorang dengan kolesterol yang tinggi disebabkan oleh kebiasaan diet tinggi kolesterol, dan berdampak buruk terhadap kesehatan jantung. Tujuan penelitian ini adalah untuk membuktikan bahwa pemberian diet tinggi kolesterol berpengaruh terhadap peningkatan kadar glukosa darah selama kehamilan. Penelitian ini menggunakan metode true experiment randomized dengan rancangan post test only group. Sampel pada penelitian ini menggunakan 18 ekor tikus putih (Rattus norvegicus) bunting, lalu sampel dibagi menjadi 2 kelompok (kontrol dan perlakuan). Kelompok kontrol diberikan pakan standar 20 gram/hari sedangkan kelompok kontrol diberikan diet tinggi kolesterol 20 gram/hari selama 18 hari kebuntingan. Pada hari ke 19 kebuntingan, akan dilakukan pengambilan darah untuk pemeriksaan kadar glukosa darah. Data hasil penelitian diuji independent t-test yang menyatakan bahwa terdapat perbedaan kadar glukosa darah yang signifikan (p=0,03) antara kelompok kontrol dan perlakuan. Kesimpulan peneliti adalah diet tinggi kolesterol terbukti meningkatkan glukosa darah pada kelompok perlakuan.
English Abstract
Gestational diabetes mellitus is the condition of pregnant women with high blood glucose. Gestational diabetes mellitus has bad impacts on mother and fetus such as caesarean section, macrosomia, shoulder dystocia and infant mortality. Diabetes occurs due to glucose metabolic disorder causes insulin resistance, insulin resistance is closely related to increased cholesterol. Someone with high cholesterol is caused by high cholesterol diet habits and has bad impact on cardiovascular health. This study was aimed to prove that high cholesterol diet affected the increased blood glucose during pregnancy. This study used method of true experiment with randomized post test only group design. This study used 18 pregnant white rats (Rates norvegicus) was divided into two groups (control and treatment). For 18 days of pregnancy, control group was given 20 gram/ day standard diet, while the treatment group received 20 gram/day high cholesterol diet. On day 19 of pregnancy, their blood was taken for blood glucose measurement. The results was tested using Independent t-test and showed significant difference (p=0,03) in blood glucose between control and treatment groups. Conclusion of this study is that high diet cholesterol is proven to increase blood glucose in treatment group.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/108/051909207 |
| Uncontrolled Keywords: | diet tinggi kolesterol, kadar glukosa darah, tikus putih bunting, high cholesterol diet, blood glucose levels, pregnant white rats. |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 19 Jul 2020 04:13 |
| Last Modified: | 11 Mar 2022 07:04 |
| URI: | http://repository.ub.ac.id/id/eprint/175229 |
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