Mandiri, Hannisa Triesani (2018) Pengaruh Jumlah Parasetamol sebagai Bahan Aktif dalam Membran PVA Terhadap Kinerja Sensor Potensiometri Parasetamol. Sarjana thesis, Universitas Brawijaya.
Abstract
Penentuan kadar parasetamol dapat dilakukan secara elektrokimia dengan menggunakan sensor potensiometri. Penelitian ini mempelajari pengaruh kadar bahan aktif terhadap bilangan Nernst dan karakterisasi terhadap sensor yang telah dibuat. Kadar parasetamol (% w/w) yang dipelajari adalah 1%, 2%, dan 3%. Pengukuran dilakukan dengan menggunakan larutan parasetamol dengan konsentrasi 10-9 M hingga 5x10-3 M pada pH 7 tanpa pengaturan pH. Karakter sensor yang diketahui meliputi pH kerja, bilangan Nernst, kisaran konsentrasi, dan waktu respon. Sensor potensiometri parasetamol dibuat dengan melapisi permukaan Screen Printed Carbon Electrode (SPCE) dengan membran selektif PVA terikat silang glutaraldehid sebanyak 5 µL. Berdasarkan hasil penelitian, peningkatan kadar parasetamol sebagai bahan aktif dalam membran dapat meningkatkan bilangan Nernst. pH larutan yang dipelajari adalah 7, 8, 9, 10, dan 11. Sensor parasetamol menunjukkan kinerja terbaik pada pH 10. Kinerja tersebut adalah nilai bilangan Nernst sebesar 35,8 mV/dekade pada kisaran konsentrasi 10-9 – 10-4 M dengan waktu respon 170 detik.
English Abstract
Determination of paracetamol could be done electrochemically by using potentiometric sensor. This research studied the effect of the amount of active material on Nernst factor and characterization on sensor that has been made. The amount of paracetamol (% w/w) used in this study were 1%, 2%, and 3%. The measurements were carried out in paracetamol solution at concentrations of 10-9 to 5x10-3 M at pH 7 without adjustment. Sensor characteristics which were studied include working pH, Nernst factor, concentration range, and response time. The paracetamol potentiometric sensor was made by coating the surface of a Screen Printed Carbon Electrode (SPCE) with 5 µL PVA selective membrane crosslinked with glutaraldehyde. Based on the results of the study, increased levels of paracetamol as an active material in the membrane could increase the Nernst factor. The pH of the studied solution were 7, 8, 9, 10, and 11. Paracetamol sensor showed the best performance at pH 10. The performance was a Nernst value of 35.8 mV/decade in the concentration range 10-9 to 10-4 M with response time of 170 seconds.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/MIPA/2018/385/051807960 |
| Uncontrolled Keywords: | sensor parasetamol, kadar bahan aktif, membran PVA, paracetamol sensor, the amount of active material, PVA membrane |
| Subjects: | 500 Natural sciences and mathematics > 541 Physical chemistry > 541.3 Miscellaneous topics in physical chemistry > 541.37 Electrochemistry and magnetochemistry |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam > Kimia |
| Depositing User: | Nur Cholis |
| Date Deposited: | 03 Jul 2020 04:19 |
| Last Modified: | 22 Oct 2021 22:41 |
| URI: | http://repository.ub.ac.id/id/eprint/168448 |
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