Suprapto, Elviara Martha Tinova (2018) Efek Ekstrak Etanol Ubi Jalar Ungu (Ipomoea batatas L.) Topikal terhadap Ketebalan Re-epitelisasi Penyembuhan Luka Tikus Rattus norvegicus Strain Wistar Model Diabetes. Sarjana thesis, Universitas Brawijaya.
Abstract
Diabetes melitus dapat mencetuskan berbagai komplikasi makrovaskular dan mikrovaskular, salah satunya adalah luka kaki diabetik yang prevalensinya tinggi dan merupakan komplikasi diabetes yang utama. Salah satu potogenesis luka diabetik yaitu melalui peningkatan stress oksidatif. Overproduksi ROS pada kondisi diabetes menyebabkan perubahan patologis pada penyemuhan luka, seperti peningkatan sitokin proinflamasi dan kelainan faktor pertumbuhan yang dapat menyebabkan lamanya pembentukan re-epitelisasi. Untuk menghentikan peningkatan ROS maka diperlukan pemberian antioksidan, seperti ubi jalar ungu. Tujuan dari penelitian ini untuk mengetahui efektifitas gel ekstrak etanol ubi jalar ungu terhadap ketebalan re-epitelisasi. Penelitian ini bersifat eksperimental menggunakan 20 tikus Rattus norvegicus strain wistar jantan berusia 10-12 minggu dieksisi dipunggung dengan ukuran 1,5x1,5 cm, luka derajat 1. Tikus dikelompokkan menjadi 4 kelompok (1) Kontrol negatif (2) Kontrol positif (tikus diabetes dengan gel plasebo) (3) Tikus diabetes yang diberikan perlakuan topikal gel ekstrak etanol ubiljalar ungu dosis 10% (4) tikus diabetes yang diberikan perlakuan topikal gel ekstrak etanol ubiljalarlungu dosis 15%. Diamati ketebalan re-epitelisasi secara histopatologi pada hari ke-14. Hasil penelitian menunjukkan adanya peningkatan ketebalan re-epitelisasi pada tikus perlakuan dengan pemberian gel ekstrak etanol ubi jalar ungu. Analisis statistik dengan uji One Way Anova diketahui bahwa tidak terdapat perbedaan ketebalan re-epitelisasi yang signifikan antar kelompok perlakuan (p = 0,741). Penelitian ini menyimpulkan bahwa ekstraki etanoli ubil jalariungui (Ipomoeal batatasi L.) dapat meningkatan ketebalan re-epitelisasi namun tidak signifikan.
English Abstract
Diabetes mellitus can trigger various macrovascular and microvascular complications, one of which is diabetic foot ulcer, which become major complication of diabetes. One of the pathogenesis of diabetic ulcer is through increased oxidative stress. Overproduction of ROS in diabetic conditions causes pathological changes in wound healing, such as an increase in proinflammatory cytokines and growth factor abnormalities that can cause longer periods of reepithelialization. To decrease the increase number of ROS, it is necessary to provide antioxidants, such as purple sweet potato. The aim of this study was to determine the efficacy of purple sweet potato ethanol extract on reepithelialization thickness. This study was experimental using twenty male Rattus norvegicus strain wistar aged 10-12 weeks were excised in the back with 1,5 X 1,5 cm width, 1 grade wound. Rats were divided into 4 groups (1) negative control (2) positive control (diabetic rats with placebo gel) (3) diabetic rats given 10% purple sweet potato ethanol extract gel (4) diabetic rats given 15% purple sweet potato ethanol extract gel. Re-epithelialization thickness was observed using histopathology examination. The results showed an increase of reepithelialization thickness in treated group given purple sweet potato ethanol extract gel. Statistical analysis One Way Anova test showed no significant difference of re-epithelialization thickness between treated groups (p = 0,741). It can be concluded that topical extract of purple sweet potato (Ipomoea batatas L.) can increase re-epithelialization thickness of diabetic ulcer but not significant
Other obstract
-
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/585/051901158 |
| Uncontrolled Keywords: | luka diabetik, ubi jalar ungu (Ipomoea batatas L.), penyembuhan luka ketebalan re-epitelisasi, diabetic ulcer, purple sweet potato (Ipomoea batatas L.), wound healing, re-epithelialization thickness |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.323 94 Drugs derived from spesific plants (Convolvulaceae) |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 04 Jul 2019 02:37 |
| Last Modified: | 31 Mar 2023 07:44 |
| URI: | http://repository.ub.ac.id/id/eprint/168144 |
Preview |
Text
Elviara Martha Tinova Suprapto.pdf Download (7MB) | Preview |
Actions (login required)
 |
View Item |