Hudayana, Nur (2018) Analisa Kadar Enzim Laktat Dehidrogenase (LDH) Serum dan Respon Objektif (metode RECIST) pada Pasien Kanker Paru Post Kemoterapi siklus ketiga dan siklus keenam di RSUD dr. Saiful Anwar Malang. Sarjana thesis, Universitas Brawijaya.
Abstract
Kanker paru merupakan penyakit yang menyebabkan kematian terbanyak kejadian kanker diseluruh dunia. Kanker paru memiliki progresivitas yang tinggi sehingga membutuhkan energi saat sel-sel berproliferasi melalui jalur anaerob. Salah satu enzim yang bekerja dalam proses ini adalah laktat dehidrogenase (LDH) serum, sehingga kadarnya mengalami peningkatan pada kanker paru. Penelitian ini bertujuan untuk mengetahui perubahan kadar laktat dehidrogrenase serum berdasarkan respon objektif metode RECIST (Response Evaluation Criteria in Solid Tumor) post kemoterapi pasien kanker paru di RSUD dr. Saiful Anwar Malang melalui rekam medis dari bulan Januari sampai dengan Juli 2018. Penelitian dilakukan pada 16 pasien penderita kanker paru yang memenuhi kriteria inklusi yang belum pernah mendapat kemoterapi kemudian diikuti hingga kemoterapi siklus ketiga dan keenam. Didapatkan penelitian menunjukkan rerata kadar LDH serum sebelum kemoterapi meningkat (530.44 U/L) dibandingkan nilai normal (240-480 U/L) dengan kanker jenis SCLC (619.50 U/L) memiliki rerata kadar yang lebih tinggi dibandingkan NSCLC (517.71 U/L). Terdapat penurunan yang signifikan rerata kadar LDH serum setelah kemoterapi siklus ketiga (p=0.026) dibandingkan sebelum kemoterapi. Pada kemoterapi siklus keenam terjadi penurunan yang tidak signifikan (p= 0.438) dibandingkan sebelum kemoterapi. Didapatkan penurunan yang tidak signifikan diseluruh respon objektif partial response dan stable disease setelah kemoterapi siklus keenam. Pada respon objektif progressive disease mengalami peningkatan rerata kadar LDH serum setelah siklus ketiga dan keenam. Kesimpulan penelitian terjadi peningkatan rerata kadar LDH serum pada kanker paru sebelum kemoterapi. Setelah kemoterapi siklus ketiga mengalami penurunan dan setelah siklus keenam mengalami peningkatan kembali. Rerata kadar LDH serum terjadi peningkatan pada progressive disease hingga kemoterapi siklus keenam
English Abstract
Lung cancer is the disease which cause most mortality cancer event in the world. Lung Cancer has a highly progress so need energy when proliferation their cells through anaerobes pathways. One of enzym which works in this process is lactate dehydrogenase serum, so that its levels always increasing in lung cancer. This research aims to know changing lactate dehydrogenase serum levels and objective response with RECIST (Response Evaluation Criteria in Solid Tumor) post chemotherapy lung cancer patient in RSUD dr. Saiful Anwar Malang by medical records from January until July 2018. This research conducted in lung cancer patients who include on inclution criteria. The study was conducted in 16 patients who never had chemotheraphy before then followed until three and six cycle. In this research, there is average of lactat dehydrogenase serum levels before chemotherapy increased (530.44 U/L) than normal value (240 – 480 U/L) with SCLC (619.50 U/L) has a higher value than NSCLC (517.71 U/L). There is significant change after chemotherapy three cycle with p= 0.026 than before. In the six cycle of chemotherapy has unsignificant change with p=0.438 than before. There is unsignificant change in all of the objective response partial response and stable disease after chemotherapy six cycle. On objective response progressive disease has increasing level both on three and six cycle after chemotherapy. The conclution, there is an increasing LDH serum level before chemotherapy on lung cancer. After three cycle of chemotherapy has decreasing level and the six cycle of chemotherapy LDH serum level back to increase again. Average of LDH serum level has usually increasing on progressive disease until six cycle of chemotherapy.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/390/051811814 |
| Uncontrolled Keywords: | Kanker Paru, LDH Serum, RECIST, Kemoterapi, Lung Cancer, lactate dehydrogenase serum, RECIST, chemotherapy |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.9 Other disease > 616.99 Tumors and miscellaneous communicable diseases > 616.994 Cancers > 616.994 24 Lungs--Cancer > 616.994 240 61 Lungs--Cancer--Chemotherapy |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 27 May 2020 13:07 |
| Last Modified: | 21 Oct 2021 04:18 |
| URI: | http://repository.ub.ac.id/id/eprint/167935 |
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