Kintari, Biyan Aulia (2018) Pengaruh Gel Ekstrak Daun Kersen (Muntingia calabura L) terhadap Jumlah Fibrolas pada Penyembuhan Ulkus Traumatik Mukosa Tikus Putih (Rattus novergicus). Sarjana thesis, Universitas Brawijaya.
Abstract
Ulkus traumatik dapat menimbulkan luka pada mukosa rongga mulut oleh karena trauma fisik, thermal atau kimiawi. Pada proses penyembuhan ulkus, fibroblas berperan penting karena mensintesis kolagen. Daun kersen (Muntingia calabura L) mengandung senyawa flavonoid, tanin, saponin yang dapat mempercepat proses penyembuhan ulkus dengan meningkatkan jumlah fibroblas. Tujuan penelitian ini untuk mengetahui pengaruh gel ekstrak daun kersen (Muntingia calabura L) terhadap jumlah fibroblas, pada proses penyembuhan ulkus traumatik mukosa tikus putih (Rattus novergicus) yang diinduksi panas. Penelitian ini menggunakan metode Post Test Only Randomized Control Grup Design, yang dibagi 6 kelompok, yaitu kelompok kontrol (K3,K5,K7) serta kelompok perlakuan (P3,P5,P7). Penghitungan jumlah fibroblas dalam sediaan histologi dengan perwarnaan HE diamati dengan mikroskop elektrik (OLYVIA) dengan pembesaran 40x. Analisis data menggunakan uji-T tidak berpasangan (p < 0,05) didapatkan perbedaan yang signifikan antar kelompok kontrol dan perlakuan. Kesimpulan dari penelitian ini yaitu gel ekstrak daun kersen (Muntingia calabura L) berpengaruh terhadap jumlah fibroblas ulkus traumatik mukosa tikus putih (Rattus novergicus) yang diinduksi panas.
English Abstract
Traumatic ulcers can cause injury to the oral mucosa caused by physical, thermal or chemical trauma. Fibroblast play an important role in ulcer wound healing to synthesis collagen. Flavonoid, tanin, saponin in Kersen leaf (Muntingia calabura L) can accelerate ulcer wound healing by increase numbers of fibroblast. The purpose of this study is to determine effect of the kersen leaf (Muntingia calabura L) extract gel to numbers of fibroblast on traumatic ulcer wound healing process of white rats (Rattus novergicus) induced by heat. This study used Post Test Only Randomized Control Grup Design divided into 6 groups (the 3rd, 5 th, 7 th day control group) and (the 3rd, 5 th, 7 th day treatment group). Sample of mucosa tissue were processed for histological slide by using HE staining was observed with a electrical microscope (OLYVIA) with magnification 40x. Data analysis using unpaired Ttes (p<0,05) showed that there were significantly different numbers of fibroblas between the control and treatment groups. The conclusion of this study is the kersen leaf (Muntingia calabura L) extract gel has effect to increase the number of fibroblast in ulcer wound healing process of white rats (Rattus novergicus) induced by heat.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKG/2018/69/051900418 |
| Uncontrolled Keywords: | Fibroblas, Gel ekstrak daun kersen, penyembuhan ulkus, Ulkus traumatik Fibroblast, Kersen leaf (Muntingia calabura L) extract gel, Traumatic ulcer, Ulcer wound healing |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry > 617.63 Dental diseases > 617.632 Diseases of gums and tooth sockets / Periodontics > 617.632 06 Periodontics--Treatment / Gingivitis--Treatment > 617.632 061 Periodontics--Chemotherapy |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 17 May 2020 06:43 |
| Last Modified: | 21 Oct 2021 11:31 |
| URI: | http://repository.ub.ac.id/id/eprint/167700 |
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