kurniawati, Mufidatul Ilmi (2018) Formulasi Etosom Ekstrak Tebu (Saccharum Officinarum) sebagai Bahan Dasar Pembuatan Patch Antidiabetes. Sarjana thesis, Universitas Brawijaya.
Abstract
Penanganan diabetes yang tersedia terbatas pada pengobatan oral, dan injeksi insulin, sementara pengobatan harus dilakukan seumur hidup, dimana dapat menurunkan kepatuhan pasien dan keberhasilan terapi. Kendati demikian, jalur administrasi lainnya telah dikembangkan, seperti rute transdermal. Kemampuan transdermal telah diakui dapat meningkatkan kepatuhan pasien. Namun, rute transdermal memiliki keterbatasan jumlah obat yang dapat terpenetrasi. Tujuan dari penelitian ini adalah untuk mengetahui formulasi optimum etosom dari ekstrak tebu (Saccharum officinarum) sebagai bahan dasar untuk patch antidiabetes. Tebu (Saccharum offiicnarum) diekstraksi menggunakan metode maserasi digesti dengan pelarut etanol 50%. Dalam penelitian ini, dilakukan pembuatan etosom dan karakterisasi pH serta ukuran partikel etosom. Etosom disiapkan dalam tiga formula sesuai persentase etanol (45%; 40%; 35%). Etosom ekstrak tebu dikarakterisasi organoleptic, pH dan ukuran partikel, serta nilai distribusi ukuran partikel (nilai span). Ekstrak tebu yang dihasilkan memiliki rendemen sebesar 26,1194% dan positif mengandung sakarin. Formula etosom optimum dalam penelitian ini yaitu Formula A dengan pH 5,1167 + 0,05033, ukuran partikel 31,9933 + 26,42639, dan nilai span 4,37267 + 2,921182. Semua formula menunjukkan perbedaan pH tidak signifikan secara Kruskal-Wallis dengan nilai p>0,05 dan perbedaan ukuran partikel yang tidak signifikan dengan nilai p>0,05 uji One Way ANOVA. Hasil tersebut menunjukkan bahwa persentase etanol tidak berpengaruh signifikan terhadap pH dan ukuran partikel etosom.
English Abstract
The available diabetic treatments are limited in oral medicine, and insulin injection, while the treatment should be taken for life time, in which can decrease patient compliance and succeed of therapy. In spite of that, other administration routes have been developed, such as transdermal. Transdermal ability to increase patient compliance is approved. However, the transdermal route has limitation penetrated drugs. The goal of this study is finding the optimum formulation of ethosomes from sugar cane extract (Saccharum officinarum) as basic ingredient for antidiabetic patch. Sugarcane (Saccharum offiicnarum) was extracted using the digesti maceration method with ethanol 50% as solvent. In this study, both ethosomes preparation and ethosomes particle size characterization were conducted. Ethosomes prepared in three formulas according to the percentage of ethanol (45%; 40%; 35%). The ethosome of sugarcane extract is characterized by organoleptic, pH and particle size, as well as particle size distribution values (span values). The resulting sugarcane extract has a yield of 26.1194% and positively contains saccharin. The optimum etosomal formula in this research was Formula A with pH 5.1167 + 0.05033, particle size 31.9933 + 26.42639, and span value 4.37267 + 2.921182. All formulas showed an insignificant difference of pH in the Kruskal- Wallis with p> 0.05 and insignificant difference of particle size with p> 0.05 One Way ANOVA test. The result implied that percentage of ethanol had no significant impact in both ethosomes particle size and pH.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/14/051803000 |
| Uncontrolled Keywords: | Antidiabetik, Saccharum officinarum, etosom, optimum-Antidiabetic, Saccharum officinarum, ethosomes, optimum |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.4 Diseases of endocrine, hematopoietic, lymphatic, glandular system; diseases of male breast > 616.46 Diseases of islands of Langerhans > 616.462 Diabetes mellitus |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 02 May 2020 00:54 |
| Last Modified: | 21 Oct 2021 07:55 |
| URI: | http://repository.ub.ac.id/id/eprint/167392 |
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