Tauran, Adrianne Marisa (2018) Studi Kohort: Kadar Supar Pada Pasien Kanker Paru Yang Mendapat Kemoterapi Dihubungkan Dengan Respons Kemoterapi Menurut Recist. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Kanker paru merupakan penyakit keganasan tersering di dunia, dengan angka kematian tertinggi di antara semua penyakit kanker. Ada kebutuhan biomarker yang mendesak dalam evaluasi tatatalaksana kanker paru. Peningkatan kadar soluble urokinase Plasminogen Activator Receptor (suPAR) berkorelasi positif dengan stadium penyakit, metastasis, dan prognosis kanker paru. Pemberian kemoterapi pada pasien kanker paru diduga dapat menurunkan kadar suPAR. Tujuan: Membuktikan perbedaan kadar suPAR pada pasien kanker paru sebelum dan setelah kemoterapi siklus ke-3 dan/atau ke-6. Metode: Studi kohort yang mengukur kadar suPAR dengan teknik ELISA pada 18 pasien kanker paru stadium III atau IV yang belum mendapat kemoterapi (suPAR1) dan setelah kemoterapi siklus ke-3 (suPAR2); dan 9 pasien setelah kemoterapi siklus ke-6 (suPAR3). Respons kemoterapi dievaluasi menggunakan Response Evaluation Criteria in Solid Tumors (RECIST). Hasil: Terdapat peningkatan yang tidak bermakna pada suPAR2 (7,181 ± 3,641 ng/ml), dan suPAR3 (9,591 ± 5,895 ng/ml) dibandingkan suPAR1 (7,042 ± 3,116 ng/ml) (p 0,569). Tidak didapatkan perbedaan bermakna antara suPAR1 dan suPAR2 berdasarkan kelompok RECIST (partial response (p = 0,332), stable disease (p = 0,670), dan progressive disease (p = 0,694)). Tidak didapatkan pula perbedaan bermakna antara suPAR1 dan suPAR3 berdasarkan kelompok RECIST (partial response (p = 0,285), dan progressive disease (p = 0,293)). Kesimpulan: Tidak ada perbedaan kadar suPAR pada pasien kanker paru sebelum kemoterapi, setelah kemoterapi siklus ke-3 dan ke-6. Tidak ada perbedaan kadar suPAR pada pasien kanker paru setelah kemoterapi siklus ke-3 dan ke- 6 berdasarkan respons kemoterapi menurut RECIST.
English Abstract
Background: Lung cancer is the most common malignant disease in the world, with the highest mortality rate among all cancer diseases. There is an urgent need for biomarkers to evaluate lung cancer management. Increased levels of soluble urokinase Plasminogen Activator Receptor (suPAR) have positive correlation with staging, metastase, and prognosis of lung cancer. Chemotherapy in lung cancer is expected to decrease suPAR levels. Objective: To prove the suPAR differences levels in lung cancer patients before and after 3rd and/or 6th chemotherapy. Methods: Cohort study which measure suPAR levels using ELISA in stage III or IV of 18 lung cancer patients who had not received chemotherapy (suPAR1) and after 3rd chemotherapy (suPAR2); and 9 patients after the 6thchemotherapy (suPAR3). Chemotherapy response was evaluated using Response Evaluation Criteria in Solid Tumors (RECIST). Results: There was a non-significant increase of suPAR2 (7,181 ± 3,641 ng/ml), suPAR3 (9,591 ± 5,895 ng/ml) compared with suPAR1 (7,042 ± 3,116 ng/ml) (p 0,569). There was no significant difference between suPAR1 and suPAR2 based on RECIST (partial response (p 0.332), stable disease (p 0.293), and progressive disease (p 0.694)). There was also no significant difference between suPAR1 and suPAR3 based on RECIST (partial response (p 0.285), and progressive disease (p 0.293)). Conclusion: There were no differences in suPAR levels in lung cancer patients before, after the 3rd and 6th chemotherapy. There were no differences in suPAR levels in lung cancer patients after the 3rd and 6th chemotherapy based on RECIST chemotherapy response.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.994 24/TAU/s/2018/041805379 |
| Uncontrolled Keywords: | LUNGS - CANCER, CANCER - CHEMOTHERAPY |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.9 Other disease > 616.99 Tumors and miscellaneous communicable diseases > 616.994 Cancers > 616.994 24 Lungs--Cancer |
| Divisions: | Profesi Kedokteran > Spesialis Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran |
| Depositing User: | Nur Cholis |
| Date Deposited: | 19 Mar 2019 06:53 |
| Last Modified: | 19 Mar 2019 06:53 |
| URI: | http://repository.ub.ac.id/id/eprint/165580 |
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