Merdikaningsih, Thiba Dina (2018) Analisa Kadar Procalsitonin Urin, Bakteriuria Dan Gambaran Pola Scattergram Sebagai Petanda Diagnosis Infeksi Saluran Kemih (Isk). Magister thesis, Universitas Brawijaya.
Abstract
ISK merupakan salah satu penyakit infeksi yang sering asimtomatik dan dapat menimbulkan sepsis. Kultur urin, standar baku diagnosis ISK, tidak mudah dan lama, untuk itu perlu petanda diagnosa yang lebih cepat. Belum diketahui peran PCT urin sebagai petanda diagnosa ISK dihubungkan dengan bakteriuria dan gambaran scattergram urin. Penelitian ini bertujuan untuk mencari petanda biologi diagnosis ISK yang lebih cepat dari kultur urin. Penelitian analitik observasional dengan desain potong lintang yang dilakukan pada 51 pasien ISK kultur positif, 16 pasien ISK kultur negatif dan 16 kontrol sehat. Kadar PCT urin diperiksa dengan metode ELISA dan analisa urin secara flowcytometry menggunakan Sysmex UF-2000. Hasil penelitian ini menunjukkan nilai diagnostik untuk PCT urin didapatkan cut off 805,85 ng/ml dengan sensitivitas 61% dan spesifitas 66%, untuk bakteriurin didapatkan cut off 755/µL dengan sensitivitas 80,39% dan spesifitas 59,09%. Terdapat perbedaan bermakna antara PCT urin pada ISK kultur positif maupun negatif dibandingkan dengan kontrol sehat p= 0,022. Tidak didapatkan perbedaan yang bermakna antara kadar PCT urin dengan gambaran pola scattergram maupun PCT urin dengan jumlah bakteriuri dengan p=0,307 dan p=867. Kesimpulan dari penelitian ini adalah jumlah bakteriuri lebih baik dibanding kadar PCT urin untuk diagnosis ISK.
English Abstract
UTI is one of the most common asymptomatic infection disease that can caused sepsis. Urine culture, as gold standard of UTI diagnosis, was not simple and took a long time, and because of that faster diagnostic marker was needed. The role of urinary procalcitonin as diagnostic marker of UTI was not established. This research aims to find a faster biologic diagnostic marker of UTI compared to urinary culture. An analytical observational study with cross sectional design was performed on 51 patients with positive culture result, 16 patients with negative culture result, and 16 healthy control. Urinary PCT level was examined with ELISA method and urinalysis was performed with flowcytometry using Sysmex UF-2000. The study result showed cut off of diagnostic value for urinary PCT was 805,85 ng/ml with sensitivity 61% and specificity 66%, while the cut off for bacteriuria was 755/µL with sensitivity 80,39% ans specificity 59,09%. There were significant differences between urinary PCT level with scattergram pattern and also urinary PCT with amount of bacteriuria with p=0,307 and p=867. The conclusion of this study is the amount of the bacteriuria is a better parameter than urinary PCT for UTI diagnosis.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.6/MER/a/2018/041804674 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.6 Diseases of urogenital system |
| Divisions: | Profesi Kedokteran > Spesialis Patologi Klinik, Fakultas Kedokteran |
| Depositing User: | Nur Cholis |
| Date Deposited: | 20 Dec 2018 07:21 |
| Last Modified: | 22 Oct 2021 03:52 |
| URI: | http://repository.ub.ac.id/id/eprint/162232 |
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