Puspitasari, Leny (2012) Korelasi Kadar Vitamin D Serum dengan Aktifitas Penyakit Lupus Erythematosus Sistemik (SLEDAI). Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang : Vitamin D diketahuimerupakan imunomodulator. Beberapa penelitian menunjukkan kadar vitamin D yang rendah pada pasien dengan penyakit autoimun termasuk LES dan berhubungan dengan keparahan penyakitnya. Tujuan penelitian ini adalah untuk mengetahui status vitamin D pada pasien LES dan hubungan kadar serum vitamin D dengan aktivitas penyakit pada pasien Lupus Ery matosus Sistemik. Metode : Subyek penelitian ini adalah pasien LES (berdasarkan kriteria ACR 1997) berusia 14 - 60 tahun, dan subyek sehat dengan usia yang setara. Kadar serum vitamin D (25(OH)D3) diukur dengan menggunakan ELISA. Aktivitas penyakit LES diukur dengan SLEDAI. Hubungan antara serum vitamin D dan aktivitas penyakit dianalisis dengan Spearman. Kadar vitamin D pada pasien LESdan subyek sehat dibandingkan dengan menggunakan mann whittney. Hasil : Diperoleh enam puluh tiga pasien LES dan duapuluh subyek sehat dalam penelitian ini. Kadar serum vitamin D pada pasien LES adalah 20,1 + 17,0 ng/mL (nilai normal 30 ng/ml) dan pada subyek sehat 36,9 + 5.3ng/ml. Kadar Vitamin D pada pasien LES lebih rendah dari pada kadar vitamin D pada subyek sehat (p = 0,000). Tiga puluh delapan pasien LES (60,3%) memiliki kadar vitamin D 20 ng/mL yang didefinisikan sebagai defisiensi vitamin D, lima belas pasien (23,8%) dengan defisiensi vitamin D (kadar vitamin D adalah 20-30 ng/mL). Kadar vitamin D normal ditemukan pada sepuluh pasien LES (15,9%). Kadar serum vitamin D berkorelasi negatif dengan SLEDAI (r = -0,659, p = 0,000). Kadar vitamin D berkorelasi dengan SLEDAI subscore yaitu silider urine, hematuria, alopecia, ulkus mukosa, dan pleuritis. Kesimpulan : Kadar vitamin D rendah sering terjadi pada pasien LES, dan kadar vitamin D pada pasien LES lebih rendah dibanding pada subyek normal. Kadar serum vitamin D berkorelasi terbalik dengan SLEDAI.
English Abstract
Background: Vitamin D is known to have an effect in controlling immune system and autoimmunity. Several researches showed low vitamin D level in autoimmune disease patients and related with disease severity. objective of this study was to determine vitamin D status in our patients with SLE and relationship of serum vitamin D concentrations with disease activity of patients with Systemic Lupus Ery matosus. Subjects and Methods: Subject of this study was SLE patients (based on ACR 1997 criteria) aged 14 – 60 years old, and healthy subject with matched age. Serum vitamin D (25(OH)D3) level were assessed using ELISA method. SLE disease activity measured by SLEDAI. data obtained processed by using SPSS and correlation between serum vitamin D and disease activity was analysed with Spearman. Vitamin D levels in SLE patients and normal subjects were compared using mann whittney. Results: Sixty three SLE patients and twenty healthy subjects were obtained in this study. Serum level of vitamin D in SLE patients was 20.1 + 17.0 ng/mL (normal value 30 ng/ml) and in healthy subjects 36.0 + 5.7 ng/ml. Vitamin D level of SLE patients was significantly lower than one in healthy subjects (p=0.000) Thirty eight SLE patients (60.3%) had vitamin D levels 20 ng/mL which is defined as a deficiency of vitamin D, fifteen patients (23.8%) had vitamin D insufficiency (levels of vitamin D is 20-30 ng/mL). Normal vitamin D level were found in ten SLE patients (15.9%). Serum levels of vitamin D have a significant negative correlation with SLEDAI (r = -659, p = 0.000). Vitamin D level was correlated with SLEDAI subscore which are urinary silider, hematuria, alopecia, mucosal ulcer, and pleuritis. Conclusion: Low level of Vitamin D was frequent in SLE patients SLE patients had significant lower vitamin D level than one in healthy subjects. Serum vitamin D levels inversely correlate with SLEDAI.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.772/PUS/k/041202480 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.7 Diseases of musculoskeletal system |
| Divisions: | Profesi Kedokteran > Spesialis THT Kepala dan Leher, Fakultas Kedokteran |
| Depositing User: | Endro Setyobudi |
| Date Deposited: | 06 Nov 2012 11:13 |
| Last Modified: | 06 Nov 2012 11:13 |
| URI: | http://repository.ub.ac.id/id/eprint/158411 |
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