Pratamaningtias, Endah (2013) Kaitan Kadar IFN-γ dengan Indeks Aktivitas dan Indeks Kronisitas pada Nefritis Lupus. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Indeks aktivitas dan indeks kronisitas yang merupakan faktor prediksi untuk menentukan prognosis renal atau progresi dari penyakit ginjal. Keseimbangan T helper (Th) 1 dan Th2 berperan dalam terjadinya lupus nefritis. IFN-γ mempunyai peran yang besar dalam jalur nefrotogenik. Penelitian ini bertujuan untuk mengetahui kaitan kadar IFN-γ dengan indeks aktivitas dan indeks kronisitas secara histopatologis. Metode: Subyek penelitian ini adalah pasien LES (berdasarkan kriteria ACR 1997) dan memiliki gambaran nefritis lupus dari hasil biopsi, berusia 16-60 tahun. Kadar IFN-γ diukur dengan metode ELISA sebelum dilakukan biopsi ginjal. Indeks aktivitas dan indeks kronisitas dinilai menggunakan kriteria National Institute of Health (NIH). Kadar IFN-γ serum diukur dengan metode ELISA. Data karakteristik pasien ditampilkan dalam persentase atau mean±SD. Korelasi interferon gamma dengan indeks aktivitas dan indeks kronisitas menggunakan uji korelasi spearman. Hasil: 46 orang terlibat pada penelitian ini dengan rerata umur adalah 28 tahun, median lama sakit 12 bulan serta seluruh sampel mendapatkan kortikosteroid. Rerata Renal SLEDAI adalah 5.87±5.43. Sebanyak 34 orang (73.9%) mengalami anemia. 7 orang (15.2%) memiliki NL kelas II, 20 orang (43.5%) memiliki NL kelas III, 8 orang (17.4%) memiliki NL kelas IV dan 11 orang memiliki NL kelas V. Terdapat korelasi yang bermakna antara indeks aktivitas dan kreatinin (r=0.325, p=0.316) serta renal SLEDAI (r=0.389, p=0.008). Terdapat perbedaan yang bermakan dari indeks aktivitas (p=0.012) dan indeks kronisitas (p=0.000) antar kelas NL. Tidak didapatkan korelasi yang bermakna antara kadar IFN-γ dengan indeks aktivitas (r=-0.083, p=0.585), serta indeks kronisitas (p=-0.148, p=0.325). Kesimpulan: Tidak terdapat korelasi yang bermakna antara kadar IFN-γ dengan indeks aktivitas dan indeks kronisitas.
English Abstract
Background: Activity and chronicity index were predictor factors to determine prognosis and progression of lupus nephritis. Balance of Th1 and Th2 play a role in lupus nephritis. IFN-γ had crucial role in nephrotogenic pathway. This study to determine correlation among IFN-γ with activity and chronicity index. Method: This study was a cross sectional survey study. Subjects were eligible for inclusion if y fulfilled American College of Rheumatology (ACR) 1997 revised criteria for classification of SLE and had a renal biopsy consistent with lupus nephritis. IFN-γ serum level was measured at same day before biopsy was performed using enzyme-linked immunosorbent assay (ELISA). Disease activity was assessed using renal domain SLEDAI scores. Activity index and chronicity index were scored using National Institute of Health (NIH) system. IFN-γ serum levels were measured by ELISA methode. correlation among IFN-γ with acitvity and chronicity index were analyzed using Spearman correlation. Result: 46 patient eligible in this study. Mean of age was 28 years old, median duration of disease was 12 months. All of patients got corticosteroid treatment. Mean of Renal SLEDAI was 5.87±5.43. 34 patients (73.9%) had anemia. re were 7 patients (15.2%) with lupus nephritis class II, 20 patients (43.5%) with nephritis lupus class III, 8 patients (17.4%) with nephritis lupus class IV and 11 patients with lupus nephritis class V. re was significant correlation among activity index with creatinine (r=0.325, p=0.043) and renal SLEDAI (r=0.389, p=0.008). re was differences of activity index (p=0.012) and chronicity index in lupus nephritis classes (p=0.000). re was no significant correlation among IFN-γ serum levels with activity index (r=-0.083, p=0.585) and chronicity index (r=-0.148, p=0.325). Conclusion: re were no correlation among IFN-γ serum levels with activity index and chronicity index.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.772/PRA/k/041308726 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.7 Diseases of musculoskeletal system |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran |
| Depositing User: | Endro Setyobudi |
| Date Deposited: | 21 Feb 2014 13:33 |
| Last Modified: | 21 Feb 2014 13:33 |
| URI: | http://repository.ub.ac.id/id/eprint/158410 |
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