Palupi, DidinRetnoEndah (2013) Hubungan Kadar IL-10 Serum dengan Kadar Neutrophil Gelatinase-Associated Lipocalin Urin dan Kadar Rasio Protein Kreatinin Urin/PCR pada Pasien Nefritis Lupus. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Salah satu manifestasi serius dan sering LES adalah terjadinya nefritis lupus (NL). Patogenesis NL hingga saat ini masih belum jelas. Terjadinya inflamasi di glomerulus telah dikaitkan dengan tingginya kadar autoantibodi dan interaksi berbagai sitokin, salah satunya adalah interleukin 10 (IL-10). Petanda dari terjadinya keradangan di ginjal adalah meningkatnya kadar Neutrophil Gelatinase-Associated Lipocalin (NGAL) urin dan rasio protein kreatinin urin (PCR). Tujuan : Mengetahui hubungan interleukin 10 serum dengan NGAL urin dan dengan PCR pada pasien NL di RSUD. Dr. Saiful Anwar Malang. Metode: Diteliti empat puluh lima pasien NL. Diagnosis NL didasarkan histopatologi menurut kriteria WHO. Pemeriksaan kadar IL-10 serum dan NGAL urin diperiksa dengan metode ELISA sedangkan PCR diperiksa dengan autoanalizer COBAS 6000. Hubungan kadar IL-10 serum dengan kadar NGAL dan PCR dianalisis dengan uji pearson. Signifikansi statistik ditentukan bila p 0,05. Hasil: Sebagian besar pasien berjenis kelamin perempuan 43 pasien (95.6%) Rerata umur pasien NL adalah 28,8 tahun, dengan rata-rata lama sakit NL 1,99 tahun. Sebanyak 14 pasien NL menderita hipertensi (31,1%). Terdapat 32 pasien yang menderita anemia (71,1%) . 41 pasien menggunakan steroid (97,8%). Rerata skor renal SLEDAI adalah 6,49. Dari hasil biopsi didapatkan 37 pasien tergolong NL berat dan 10 orang tergolong NL ringan. Tidak didapatkan hubungan kadar IL-10 serum dangan kadar NGAL (r= -0,036, p=0,815) dan PCR (r=-0,078, p=0,078). Kesimpulan: Tidak didapatkan hubungan kadar IL-10 serum dangan kadar NGAL dan PCR. Peningkatan kadar IL-10 serum tidak diikuti peningkatkan kadar NGAL urin dan PCR.
English Abstract
Background: One of frequent and serious manifestationof Systemic Lupus Ery matosus (SLE) is occurrence of Lupus Nephritis (LN). LN pathogenesis is still unclear. Occurrence of glomerular inflammation has been associated with high levels of autoantibodies and interaction of various cytokines, one of which is interleukin 10 (IL-10). Signs of inflammation in kidney are increased levels of urine Neutrophil gelatinase-Associated Lipocalin (NGAL) and urine protein urine creatinine ratio (PCR). Objective: To determine corelation of serum interleukin 10 to urinary NGAL and to PCR in LN patients of Dr..Saiful Anwar Malang hospital. Methods: Forty-five LN patients were being observed in study. LN diagnosis was based on histopathology according to WHO criteria. level of serum IL-10 and urine NGAL were examined by ELISA while PCR were being examined by COBAS 6000 autoanalizer. Corelation of serum levels of IL-10 with levels of NGAL and PCR were analyzed with Pearson test. Statistical significance was determined when p 0.05. Results: majority of patients, as many as 43, were female (95.6%). Mean LN patient`s age was 28.8 years, with an average duration of LN illness 1.99 years. A total of 14 LN patients are suffering from hypertension (31.1%). re are 32 patients with anemia (71.1%). 41 patients using steroid (97.8%). mean renal SLEDAI score was 6.49. From biopsy results obtained, 37 patients are classified as severe LN and 10 mild LN. re was no correlation found of serum IL-10 levels to NGAL levels (r=0.036, p = 0.815) and PCR (r = -0.078, p = 0.078). Conclusion: Corelation of serum IL-10 levels to urine NGAL levels and PCR were not found. Increased serum IL-10 levels were not followed by an increasing levels of urine NGAL and PCR.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.772/PAL/h/041308721 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.7 Diseases of musculoskeletal system |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran |
| Depositing User: | Endro Setyobudi |
| Date Deposited: | 04 Mar 2014 14:18 |
| Last Modified: | 04 Mar 2014 14:18 |
| URI: | http://repository.ub.ac.id/id/eprint/158408 |
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