Ratnasari, Vivi (2014) Hubungan Kadar Vitamin D3 dengan Kadar C-Peptida serta Interleukin-2 Pada Anak dengan Diabetes Melitus Tipe 1. Magister thesis, Universitas Brawijaya.
Abstract
Diabetes melitus (DM) tipe 1 merupakan penyakit autoimun yang ditandai oleh destruksi sel beta dan defisiensi insulin absolut. Patogenesis DM tipe 1 terjadi karena hilangnya toleransi terhadap self-antigens. Defisiensi vitamin D merupakan salah satu faktor yang berperan pada patogenesis dan prevensi DM tipe 1. Berbagai penelitian menyebutkan bahwa pada penderita DM tipe 1 banyak yang mengalami defisiensi maupun sufisiensi vitamin D. Penelitian ini ingin membuktikan bahwa pada anak dengan DM tipe 1, kadar vitamin D dan C-peptida lebih rendah dibandingkan kontrol serta kadar IL-2 lebih tinggi dibandingkan kontrol dan hubungan antara ketiga parameter tersebut. Desain penelitian cross sectional, merekrut 20 pasien DM tipe 1 dan 20 kontrol, diukur kadar 25(OH)D3, C-peptida dan IL-2. Perbandingan kadar 25(OH)D3, C-peptida dan IL-2 dianalisis menggunakan independent samples t-test. Korelasi antara kadar 25(OH)D3, C-peptida dan IL-2 dianalisis menggunakan korelasi Pearson. Kadar 25(OH)D3 pada penderita DM tipe 1 lebih rendah bermakna dibandingkan kontrol (20.82±5.53 vs 33.14±2.17 ng/ml;p=0.000). Kadar C-peptida pada penderita DM tipe 1 lebih rendah bermakna dibandingkan kontrol (0.270±0.121 vs 3.255±1.080 ng/mL;p=0.000). Kadar IL-2 pada penderita DM tipe 1 lebih tinggi bermakna dibandingkan kontrol (1566.82±432.291 vs 187.500±39.586 ng/L;p=0.000). Kadar vitamin D berkorelasi positif dengan kadar C-peptida (p=0,000; r=+0,961). Kadar vitamin D berkorelasi negatif dengan kadar IL-2 (p=0,000; r=-0,753). Kadar C-peptida berkorelasi negatif dengan kadar IL-2 (p=0,002; r=-0,658). Pada anak dengan DM tipe 1, kadar vitamin D dan C-peptida lebih rendah dibandingkan kontrol serta kadar IL-2 lebih tinggi dibandingkan kontrol. Terdapat korelasi antara kadar 25(OH)D3, C-peptida dan IL-2 pada penderita DM tipe 1.
English Abstract
Diabetes mellitus (DM) type 1 is an autoimmune disease characterized by beta cell destruction and absolute insulin deficiency. This occurs due to tolerance loss to self-antigens. Vitamin D deficiency is a factor in pathogenesis and prevention of type 1 DM. Various studies suggest that in type 1 diabetes patients experience vitamin D deficiency or sufficiency. This research is to prove that in type 1 diabetes patients, vitamin D and C - peptide levels was lower than controls and IL-2 levels higher than controls and correlation between three parameters. Cross-sectional study design, recruited 20 type 1 DM patients and 20 controls, 25(OH)D3, C-peptide and IL-2 levels was measured. Comparation of 25(OH)D3, C-peptide and IL-2 levels were analyzed using independent samples t-test. Correlation between 25(OH)D3, C-peptide and IL-2 levels were analyzed using Pearsons correlation. Levels of 25(OH)D3 in type 1 DM significantly lower than controls (20.82±33.14 vs. 5.53±2.17, p=0.000). C-peptide levels in type 1 DM significantly lower than controls (0.270±0.121 vs 1.080±3,255, p=0.000). Levels of IL-2 in type 1 DM was significantly higher than controls (1566.82±432.291 ± 39.586 vs 187.500, p=0.000). Vitamin D were positively correlated with C-peptide levels (p=0.000; r=+0.961). Vitamin D were negatively correlated with IL-2 levels (p=0.000; r=-0.753). C-peptide were negatively correlated with IL-2 levels (p=0.002; r=-0.658). In type 1 diabetes patients, vitamin D and C-peptide levels is lower than controls and IL-2 levels is higher than controls. re is a correlation between levels of 25(OH)D3, C-peptide and IL- 2 in type 1 diabetes patients.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.462/RAT/h/041500343 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.4 Diseases of endocrine, hematopoietic, lymphatic, glandular system; diseases of male breast |
| Divisions: | S2/S3 > Magister Ilmu Biomedis, Fakultas Kedokteran |
| Depositing User: | Samsul Arifin |
| Date Deposited: | 22 Apr 2015 15:29 |
| Last Modified: | 22 Apr 2015 15:29 |
| URI: | http://repository.ub.ac.id/id/eprint/158369 |
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