Setyawan, UngkyAgus (2014) Penurunan Kadar Interleukin 6 Serum dan Perbaikan SGRQ serta Perbaikan Komorbid Depresi pada Populasi Pasien PPOK yang Diintervensi Rehabilitasi Medik. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Depresi merupakan komorbid utama pasien PPOK, prevalensinya 10-42%, dan berhubungan dengan penurunan status kesehatan, dan peningkatan mortalitas. Sampai saat ini belum ada penelitian terapi rehabilitasi medik dihubungkan dengan efek sistemik PPOK terutama manifestasi depresi yang dinilai berdasarkan marker inflamasi dalam darah. Tujuan penelitian ini untuk membuktikan pengaruh program rehabilitasi medik terhadap penurunan tingkat depresi populasi PPOK, perbaikan populasi PPOK, penurunan kadar IL-6, dan perbaikan kualitas hidup populasi PPOK. Metode: Penelitian klinis dengan metode quasi-experimental pada pasien PPOK depresi, masing-masing 15 pasien sebagai kelompok kontrol, dan perlakuan. Rehabilitasi medik dilakukan selama 8 minggu, dan sampel darah diambil untuk pengukuran kadar IL-6, serta dilakukan pengukuran SGRQ-C, dan BDI pada awal bulan 1, akhir bulan 2, dan akhir bulan 3. Hasil: Terdapat perbedaan tingkat depresi (p= 0.003) antara kontrol dengan perlakuan, dan terdapat perubahan populasi PPOK setelah diberikan rehabilitasi medik pada populasi PPOK B. Terdapat penurunan bermakna kadar IL-6 populasi PPOK depresi setelah perlakuan (p= 0.001). Terdapat pengaruh rehabilitasi medik terhadap parameter impact SGRQ-C (p= 0.036). Kesimpulan: Rehabilitasi medik bisa memperbaiki tingkat depresi populasi PPOK, serta menurunkan kadar IL-6 sehingga terjadi perbaikan populasi , dan kualitas hidup pasien.
English Abstract
Back Ground: Depression is a major comorbid for COPD patients, prevalence is10-42%, and associated with a decline in health status, and increase mortality. Until now re is no research of medical rehabilitation rapies associated with systemic effects of COPD primarily depression manifestation. depresion are assessed by markers of inflammation in blood. purpose of this study is to proof influence of medical rehabilitation programs to improve level of depression, quality of life, and decrease level of IL-6, and also to change group of COPD population. Method: Clinical study quasi-experimental methode to depression in COPD as patients 15 controls, and 15 performed medical rehabilitation for 8 weeks, and blood samples were taken to measure levels IL-6, SGRQ-C, and BDI measurement, at baseline, end of 2 nd and 3 rd month. Result: re are differences level of depression (p= 0.003) between control vs intervention, and re are a COPD population changes after administration of medical rehabilitation in COPD population B. re are a significant decrease levels IL-6 COPD population depression after intervention (p= 0.001). influence medical rehabilitation of impact parameter SGRQ-C (p= 0.036). Conclusion: Medical rehabilitation can improve depression level in COPD population, and lower IL-6 level resulting in improvement population , and patient`s quality of life.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.24/SET/p/041403638 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.2 Diseases of respiratory system |
| Divisions: | Profesi Kedokteran > Spesialis Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran |
| Depositing User: | Endro Setyobudi |
| Date Deposited: | 12 Aug 2014 09:43 |
| Last Modified: | 12 Aug 2014 09:43 |
| URI: | http://repository.ub.ac.id/id/eprint/158320 |
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