Silyen, Willy (2014) Hubungan Kadar 25-Hidroksivitamin D [25(Oh)D] Serum Terhadap Kadar Ige Spesifik Dan Derajat Rinitis Alergi. Magister thesis, Universitas Brawijaya.
Abstract
Rinitis alergi merupakan penyakit inflamasi mukosa hidung yang didasari oleh reaksi hipersensitifitas tipe 1 dan diperantarai oleh IgE. Dampak yang cukup signifikan akibat rinitis alergi yaitu terjadinya penurunan kualitas hidup dan biaya pengeluaran yang meningkat untuk pengobatan. Kalsiferol merupakan imunomodulator yang baik dalam menghambat IL-4, IL-5 dan IL-13 sehingga diferensiasi Th2 dan produksi IgE akan menurun. Penelitian ini bertujuan untuk mengetahui hubungan kadar kalsiferol dengan kadar IgE spesifik dan derajat rinitis alergi. Penelitian observasional analitik ini melibatkan 24 orang penderita rinitis alergi sebagai kelompok kasus dan 24 orang tanpa rinitis alergi sebagai kelompok kontrol. Perbedaan kadar kalsiferol antara kelompok kasus dan kontrol dianalisa dengan uji t tidak berpasangan, hubungan kadar kalsiferol dengan IgE spesifik dianalisa dengan uji korelasi pearson dan perbedaan kadar kalsiferol terhadap derajat rinitis alergi dianalisa dengan uji ANOVA. Kadar kalsiferol kelompok kasus berbeda bermakna dibandingkan kelompok kontrol (p 0.05), tidak terdapat hubungan kadar kalsiferol dengan kadar IgE spesifik (p0.05) dan terdapat perbedaan yang bermakna kadar kalsiferol dengan derajat rinitis alergi (p 0.05). Kesimpulan penelitian ini adalah kadar kalsiferol berbeda bermakna antara kelompok kasus dan kontrol, kadar kalsiferol tidak berhubungan dengan kadar IgE spesifik dan terdapat perbedaan yang bermakna kadar kalsiferol dengan beberapa derajat rinitis alergi. Penelitian lebih lanjut diperlukan untuk mengetahui hubungan kadar kalsiferol dengan mediator inflamasi yang berperan dalam proses aktivasi IgE spesifik seperti IL-4 dan IL-13 serta kadar kalsiferol serum dengan receptor vitamin D.
English Abstract
Allergic rhinitis is an inflammatory disease of nasal mucosa which is based on reaction of type 1 hypersensitivity and is mediated by IgE. Significant impact of allergic rhinitis cause decreased in quality of life and increased expenses for treatment. Calciferol is a good immunomodulator in inhibiting IL-4, IL-5 and IL-13 that Th2 differentiation and IgE production will decline. This study aims to determine relationship calciferol levels with specific IgE levels and degree of allergic rhinitis. This analytic observational study involved 24 people with allergic rhinitis as case group and 24 people without allergic rhinitis as a control group. Calciferol levels difference between case and control groups were analyzed by independent t test, calciferol levels relationships with specific IgE levels were analyzed by Pearson correlation test and differences in levels of calciferol on degree of allergic rhinitis were analyzed by ANOVA test. Calciferol levels significantly different from case group than control group (P 0.05), re was no correlation with levels of calciferol with specific IgE levels (p 0.05), and re is a significant difference in degree of calciferol levels with allergic rhinitis (p 0:05). conclusion of this study is calciferol levels significantly different between cases and controls, calciferol levels not associated with specific IgE levels and re is a significant difference calciferol levels with some degree of allergic rhinitis. Fur r research is needed to determine relationship within calciferol levels of inflammatory mediators that play a role in activation of specific IgE as IL-4 and IL-13, and serum calciferol levels with vitamin D receptor.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.2/s/HUB/041309856 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.2 Diseases of respiratory system |
| Divisions: | Profesi Kedokteran > Spesialis THT Kepala dan Leher, Fakultas Kedokteran |
| Depositing User: | Hasbi |
| Date Deposited: | 21 Apr 2014 09:05 |
| Last Modified: | 20 Apr 2022 05:36 |
| URI: | http://repository.ub.ac.id/id/eprint/158302 |
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