Yunita, Merry (2013) Kadar Serum Vascular Endothelial Growth Factor (VEGF) dan Pigment Epithelium Derived Factor (PEDF) pada Retinopati Diabetika. Magister thesis, Universitas Brawijaya.
Abstract
Tujuan : Mengetahui perbedaan kadar serum VEGF sesuai dengan derajat keparahan retinopati diabetika (RD) pada penderita DM tipe 2, mengetahui perbedaan kadar serum PEDF sesuai dengan derajat keparahan retinopati diabetika (RD) pada penderita DM tipe 2, mengetahui hubungan antara kadar serum VEGF terhadap PEDF sesuai dengan derajat keparahan retinopati diabetika (RD) pada penderita DM tipe 2. Metode : Desain penelitian ini adalah observasional analitik dengan pendekatan cross sectional. Rentang umur 50-70 tahun. DM tipe 2 dikelompokkan menjadi non RD, non Proliferative Diabetic Retinopathy (NPDR), Proliferatif Diabetic Retinopathy (PDR). Total sampel adalah 36 penderita (12 penderita non RD, 12 penderita NPDR dan 12 penderita PDR). Kemudian dilakukan anamnesa, pemeriksaan klinis dan pemeriksaan oftalmologi. Sampel darah (serum) diambil kemudian dilakukan pengukuran kadar serum VEGF dan PEDF menggunakan metode ELISA. Hasil pengukuran kadar serum VEGF dan PEDF kemudian dibandingkan dengan derajat keparahan RD. Data hasil pengamatan dilakukan uji ANOVA, korelasi Spearman dan Pearson. Hasil : Total didapatkan 36 sampel penelitian, terdiri dari 18 pria dan 18 wanita. Kadar serum VEGF pada kelompok DM non RD berbeda signifikan dengan kelompok NPDR dan PDR, p 0.05), terdapat hubungan positif antara kadar serum VEGF sesuai dengan derajat keparahan RD (p 0.05). Kadar serum PEDF pada kelompok DM non RD berbeda signifikan dengan kelompok NPDR dan PDR, p 0.05), terdapat hubungan positif antara kadar serum PEDF sesuai dengan derajat keparahan RD (p 0.05) . Terdapat hubungan positif antara kadar serum VEGF terhadap PEDF sesuai dengan derajat keparahan RD (p 0.05). Kesimpulan : Terdapat peningkatan kadar serum VEGF dan PEDF sesuai dengan peningkatan derajat keparahan retinopati diabetika. Peningkatan kadar serum VEGF berpengaruh terhadap peningkatan kadar serum PEDF sesuai dengan peningkatan derajat keparahan retinopati diabetika.
English Abstract
Purpose : To find out differences between VEGF serum level according to the severity of diabetic retinopathy (DR) in patients with type 2 DM, to find out differences between PEDF serum level according to the severity of diabetic retinopathy (DR) in patients with type 2 DM, and to know the relationship between VEGF and PEDF serum level with the severity of diabetic retinopathy (DR) in patients with type 2 DM. Methods : This study was observational analytic with cross-sectional approach. Sample age range between 50-70 years. DM type 2 was grouped into Non Diabetic Retinopathy , Non Proliferative Diabetic Retinopathy (NPDR), Proliferative Diabetic Retinopathy (PDR). The total sample was 36 patients (12 patients with non DR, 12 patients with NPDR and 12 patients with PDR). All patients underwent anamnesis, clinical examination and ophthalmology examination. Blood samples was taken from all patients, then serum level of VEGF and PEDF was measured using ELISA method. The serum level of VEGF and PEDF were compared with the severity of DR. Data was analized using ANOVA, Spearman correlation test and Pearson test. Results : Total of 36 samples consists of 18 men and 18 women. Serum level of VEGF in non DR group was significantly different with NPDR and PDR groups (p 0.05), there is a positive correlation between VEGF serum level and the severity of retinopathy (p 0.05). Serum level of PEDF in non DR group was significantly different with NPDR and PDR groups (p 0.05), there is a positive correlation between PEDF serum level and the severity of retinopathy (p 0.05). There is a positive correlation between VEGF and PEDF serum level with the severity of retinopathy (p 0.05). Conclusion : There are increased serum level of VEGF and PEDF correlated with increased the severity of diabetic retinopathy. Increased serum level of VEGF will increased serum level of PEDF in correlation with the severity of diabetic retinopathy.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/612.13/YUN/k/041301354 |
| Subjects: | 600 Technology (Applied sciences) > 612 Human Physiology > 612.1 Circulatory system |
| Divisions: | Profesi Kedokteran > Spesialis Ilmu Kesehatan Mata, Fakultas Kedokteran |
| Depositing User: | Endro Setyobudi |
| Date Deposited: | 04 Apr 2013 09:46 |
| Last Modified: | 04 Apr 2013 09:46 |
| URI: | http://repository.ub.ac.id/id/eprint/157963 |
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