Setiyawan, DwiHendra (2016) Mempelajari Reaksi antara Pinonaldehid dan Urea dengan Katalis Asam. Sarjana thesis, Universitas Brawijaya.
Abstract
Penelitian ini bertujuan untuk mempelajari reaksi antara pinonaldehid dan urea dalam membentuk produk dengan katalis asam. Pengaruh pelarut dan rasio mol reaktan juga dipelajari dalam kaitannya dengan pembentukan produk. Pelarut yang digunakan adalah etanol dan etilasetat, sedangkan rasio mol yang dikaji adalah perbandingan 1:1; 1:2; dan 2:1 untuk pinonaldehid dan urea. Semua kondisi reaksi dikerjakan dengan memanaskan campuran reaktan pada suhu refluks. Monitoring dan analisis produk dikerjakan dengan spektrofotometri inframerah dan ultraviolet-visibel. Disamping itu, analisis juga dikerjakan menggunakan liquid chromatography-mass spectrometry (LCMS). Hasil reaksi memberi indikasi pembentukan produk senyawa 5-(3-acetyl-2,2-dimethylcyclobutyl)-4-((3-acetyl- 2,2-dimethylcyclobutyl)methyl)-3,4-dihydropyrimidin-2(1H)-one dan mekanisme reaksinya diperkirakan mengikuti model reaksi Biginelli. Disamping itu, kepolaran pelarut berpengaruh terhadap kecepatan reaksi, reaksi dengan etanol lebih cepat dibanding dengan etil asetat. Sedangkan rasio mol reaktan tidak berpengaruh terhadap reaksi.
English Abstract
This thesis reports a recent investigation on reaction of pinonaldehyde and urea under an acid catalyst. The solvent polarity and mole ratio are learnt in order to improve product yield. Ethanol and ethyl acetate were used as solvent meanwhile mole ratio using variation 1:1, 1:2, and 2:1 for pinonaldehyde and urea, respectively. In addition, all of the reaction procedures were undergone under reflux and monitoring of the reaction progress was undertaken by sampling in each hour. The sample was then further analyzed by TLC, spectrophotometry infrared and ultraviolet-visible. Especially for product determination, it was involved liquid chromatographymass spectrometry as well. In overall, it has been found 5-(3-acetyl- 2,2-dimethylcyclobutyl)-4-((3-acetyl-2,2-dimethylcyclobutyl)methyl)- 3,4-dihydropyrimidin-2(1H)-one as the reaction product. And it is predicted that mechanism following the Biginelli-typed reaction. The presence of more polar solvent, such as ethanol, gives a shorter reaction time. In addition, the mole ratios did not effect on reaction.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/MIPA/2016/399/051610336 |
| Subjects: | 500 Natural sciences and mathematics > 540 Chemistry and allied sciences |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam > Kimia |
| Depositing User: | Kustati |
| Date Deposited: | 04 Nov 2016 09:45 |
| Last Modified: | 04 Nov 2016 09:45 |
| URI: | http://repository.ub.ac.id/id/eprint/154929 |
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