Wahyuningroom, Rike (2014) Histopatologi Hati Dan Paru Mencit (Mus Musculus) Yang Terpapar Formalin Dan Benzo(Α)Pyrene. Sarjana thesis, Universitas Brawijaya.
Abstract
Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian formalin dan benzo(α)pyrene terhadap struktur jaringan hati dan paru mencit (Mus musculus). Mencit jantan berumur dua bulan terpapar formalin dosis 2 mg/kg bb dengan perlakuan oral selama 60 hari dan terpapar benzo(α)pyrene dosis 250 mg/kg bb dengan perlakuan injeksi intraperitoneal sebanyak empat kali setelah 30 hari dengan selang waktu satu hari. Stuktur histologi hati dan paru mencit dianalisis secara deskriptif. Jumlah hepatosit yang mengalami nekrosis dianalisis dengan menggunakan uji Mann-Whitney pada software SPSS 16.0 for Windows. Hasil dari penelitian ini menunjukkan bahwa pemberian formalin, benzo(α)pyrene dan kombinasi antara formalin dan benzo(α)pyrene meningkatkan jumlah hepatosit yang mengalami nekrosis. Nekrosis terjadi di sekitar area portal triad dan di sekitar area vena sentralis pada hati mencit, sedangkan nekrosis terjadi di sekitar area vena pada paru mencit.
English Abstract
The objective of this research is to reveal the effects of formalin and benzo(α)pyrene administration on the liver and lungs histological structure in mice (Mus musculus). Two months old male mice were treated orally with formalin 2 mg/kg body weight during 60 days and injected intraperitoneally with benzo(α)pyrene 250 mg/kg body weight four times after 30 days with one day interval. Histological structure of liver and lungs were analyzed descriptively. Numbers of necrotic hepatocytes were analyzed with Mann-Whitney Test by using SPSS 16.0 for Windows software. The result showed that administration of formalin, benzo(α)pyrene and combination of formalin and benzo(α)pyrene increase the number of necrotic hepatocytes. Necrosis was found around portal triad area and central vein area in the liver, whereas necrosis was found around vein area of mice lungs.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/MIPA/2014/220/051404335 |
| Subjects: | 500 Natural sciences and mathematics > 570 Biology |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam > Biologi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 07 Aug 2014 14:02 |
| Last Modified: | 21 Oct 2021 04:07 |
| URI: | http://repository.ub.ac.id/id/eprint/153842 |
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