Rosidayanti, Endang (2018) Pengaruh Tindakan Preventif Infeksi Alami Endoparasit Pada Kambing Pe Dengan Ekstrak Daun Sambiloto (Andrographis Paniculata Nees) Terhadap Hepar Berdasarkan Jumlah Sel Radang Dan Kadar Alkaline Phospatase. Sarjana thesis, Universitas Brawijaya.
Abstract
Daun sambiloto mengandung berbagai zat seperti andrographolite, saponin, dan tannin yang mempunyai aktivitas sebagai antihelmintik, antiinflamasi, dan antioksidan. Pemberian daun Sambiloto secara oral akan di absorbsi oleh usus dan dimetabolisme di hepar yang mungkin memiliki pengaruh terhadap hepar. Penelitian ini bertujuan untuk mengetahui pengaruh tindakan preventif infeksi alami endoparasit dengan ekstrak daun sambiloto pada kambing PE terhadap hepar berdasarkan jumlah sel radang dan kadar enzim ALP. Rancangan penelitian bersifat eksperimental menggunakan Rancangan Acak Lengkap. Hewan coba kambing jantan berumur 4 bulan dengan empat kelompok perlakuan, yaitu kontrol positif (infeksi alami endoparasit) dan tiga kelompok perlakuan (infeksi alami endoparasit dan diberikan ekstrak daun Sambiloto dosis bertingkat 50, 75 dan 100 mg/kgBB) sebanyak 2 hari sekali selama 2 bulan. Jumlah sel radang pada organ hepar dianalisa secara deskriptif dengan pewarnaan HE dan kadar enzim ALP diukur menggunakan spektofotometer dan dianalisa secara statistik menggunakan ragam One-Way ANOVA dengan α=0,05. Hasil penelitian menunjukkan bahwa ekstrak daun sambiloto menurunkan jumlah sel radang pada hepar dan kadar enzim ALP terutama pada dosis 100 mg/kgBB. Kesimpulan dari penelitian ini yaitu ekstrak daun sambiloto (Andrographis paniculata Ness) dapat berperan sebagai tindakan preventif infeksi alami endoparasit pada kambing PE berdasarkan penurunan jumlah sel radang dan kadar ALP pada organ hepar.
English Abstract
Sambiloto leaves contains various substances such as andrographolide, saponins, and tannins that have activity as antihelmintic, antiinflammatory, and antioxidants. Sambiloto leaves which are given orally will be absorbed in the intestine, then will be metabolized in the liver and may have effect to the liver. The purpose of this study was to determine the effects of preventive against on natural endoparasites infection of Ettawa crossbreed goats in the liver based on the number of inflammatory cells and ALP levels. This study used Completely Randomized Design which used four month male goats and devided into four treatment groups, that are positive control (natural infection endoparasites) and three treatment groups (natural infection endoparasites and given sambiloto leaf extracts doses 50, 75 and 100 mg/kgBW) once every two days for two months. The number of inflammatory cells in the liver was analyzed descriptively by HE staining and ALP levels were measured using a spectrophotometer and analyzed statistically using One-Way ANOVA test with α=0.05. The results showed that sambiloto leaf extracts reduced the number of inflammatory cells and ALP levels, especially at doses of 100 mg/kgBW. The conclusion of this research is that sambiloto leaf extracts can be used as a preventive against endoparasites natural infections in ettawa crossbreed goat based on the decreasing number of inflammatory cells and ALP levels in the liver.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKH/2018/32/051801430 |
| Uncontrolled Keywords: | Andrographolit, Andrographis paniculata Nees, sel radang pada hepar, dan ALP.- Andrographolide, Andrographis paniculata Nees, Inflammatory cells and ALP levels. |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.323 95 Drugs derived from spesific plant (Scrophulariales) |
| Divisions: | Fakultas Kedokteran Hewan > Kedokteran Hewan |
| Depositing User: | Sugeng Moelyono |
| Date Deposited: | 05 Nov 2018 03:50 |
| Last Modified: | 21 Oct 2021 07:59 |
| URI: | http://repository.ub.ac.id/id/eprint/12802 |
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